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Protein Overview: Thiolase-PA

General Information:
Name(s) found: Thiolase-PA / FBpp0072135 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Thiolase is referred to in FlyBase by the symbol Dmel\Thiolase (CG4581, FBgn0025352). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19754124..19756139. It has the cytological map location 60A5. Based on sequence similarity, it is predicted to have molecular function</span>: long-chain-3-hydroxyacyl-CoA dehydrogenase activity; acetyl-CoA C-acyltransferase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: fatty acid beta-oxidation. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    fatty acid beta-oxidation multienzyme complex [ISS]
    Biological Process: fatty acid beta-oxidation [ISS]
    Molecular Function: acetyl-CoA C-acyltransferase activity [ISS]
    long-chain-3-hydroxyacyl-CoA dehydrogenase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLQNVCRKG NAFNLLNVAR KVQCRALSAA VANPQPKQKN SQNIVLVDGV RTPFLTSGTT  60
   61 YSKLMPHELA RHSLLSLLQK NRLDKELIDY IVYGSVIQEV KTSNIAREAA LAAGFSNKTP 120
  121 AHTVTMACIS SNAAITTGMG LIATNTYDVI VAGGVEFMSD VPIRHSRKMR SLLLKANKAK 180
  181 TLGQRLALLS TFRPDFLAPE LPAVAEFSSG ETMGHSADRL ASAFNVSRSE QDEYALRSHT 240
  241 LAKEAQEKGY FTDLVPFKVS GVDQIVDKDN GIRVSSPESL AKLRPAFVKP YGTVTAANAS 300
  301 FLTDGASACI IMTEEKAKQL GLKPKAYLRD FLFVSQDPVN QLLLGPAYGI PKLLKKAGLT 360
  361 LKDIDSWEIH EAFAGQIVAN LKALDSDWFC KTYLGLNEKV GTPDLSKWNN WGGSLSIGHP 420
  421 FAATGVRLCM HTANRLVRED GKLGVVAACA AGGQGVAMLI ERYPGATAD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..469] PSI-BLAST 87.522879 Human cytosolic acetoacetyl-CoA thiolase complexed with CoA


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle