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Protein Overview: eIF2B-delta-PB, ...

General Information:
Name(s) found: eIF2B-delta-PD / FBpp0291521 [FlyBase]
eIF2B-delta-PB / FBpp0071924 [FlyBase]
eIF2B-delta-PC / FBpp0071922 [FlyBase]
Description(s) found:
Found 38 descriptions.
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  • The gene eIF2B-Ã?&#142;Ã?´ is referred to in FlyBase by the symbol Dmel\eIF2B-Ã?&#142;Ã?´ (CG10315, FBgn0034858). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19274016..19276575. It has the cytological map location 59D9-59D10. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene eIF2B-Ã?&#142;Ã?´ is referred to in FlyBase by the symbol Dmel\eIF2B-Ã?&#142;Ã?´ (CG10315, FBgn0034858). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19274016..19276575. It has the cytological map location 59D9-59D10. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene eIF2B-Ã?&#142;Ã?´ is referred to in FlyBase by the symbol Dmel\eIF2B-Ã?&#142;Ã?´ (CG10315, FBgn0034858). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:19274016..19276575. It has the cytological map location 59D9-59D10. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 4 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 576 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS][NAS]
    eukaryotic translation initiation factor 2B complex [ISS]
    Biological Process: translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGNAVDPLA TEKTRDQIMA EREAKKLAKQ AKKQKTAPTP TAATPAVLTT PSAPATKIIT  60
   61 EVEQTTITTK LTTTTTTKVQ DAVASKTTQP AAVNGKDAEA GEKTREQIKA EREAKKAAKK 120
  121 AGKGGGAKVE GIAQQLADLK VAEKAPVAAS AAPSTTEADQ EKKKPALSKA ERRAIQEAQR 180
  181 AAKAQVQTKK AQHAAKAPPS AAPKGPNRKS VSPTTAATSS SPVKCPASTP NVDCRVKLFN 240
  241 HLVCAKEDSQ FINDPLVHPS IARLGVQYAK RTVVGSNARC IAFLHALRQV VHDFETPAKK 300
  301 EFGRSLDAAV KHHVDHLHKC RPLAVSVSNA YKQFKNQLTQ LPADVPETES KELLVHFIDT 360
  361 YIENQIGKAA QAISGFLQEK ITDGDVLLTF ACSSLIQFIC EEAKRRQVAF RVIVVDSRPG 420
  421 CEGQELLRRL HATGIPCTYV LINAVGYVMA EATKVLLGAH ALLANGYVMA RTGTAQVALV 480
  481 ANAHNVPVLV CCETHKFSER FQTDAIVYNE LSDPNQLVRG DKCQLSNWAA KGKLLPLNLS 540
  541 YDITPPELVS AVVTEVAILP CTSVPVILRI KPDIGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] deduced N/A No confident structure predictions are available.
    2 View Details [98..225] FFAS03 1.35 No description for 2j63A was found.
    3 View Details [226..576] PSI-BLAST 94.0 X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • translation initiation factor activity
    		•  10.1099993541596 bayes_pls_golite062009
  • translation regulator activity
    		•  5.74669335554405 bayes_pls_golite062009
  • catalytic activity
    		•  1.31732715713197 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.09424756417577 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.690575841886046 bayes_pls_golite062009
  • binding
    		•  0.306360407226215 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle