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View Structure Prediction Details

Protein: eIF2B-delta-PB, ...
Organism: Drosophila melanogaster
Length: 576 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF2B-delta-PB, ....

Description E-value Query
Range
Subject
Range
gi|114576634 - gi|114576634|ref|XP_001157464.1| PREDICTED: eukaryotic translation initiation factor 2B, subunit 4 d...
346.0 [0..53] [571..2]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGNAVDPLA TEKTRDQIMA EREAKKLAKQ AKKQKTAPTP TAATPAVLTT PSAPATKIIT  60
   61 EVEQTTITTK LTTTTTTKVQ DAVASKTTQP AAVNGKD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [98-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEAGEKTREQ IKAEREAKKA AKKAGKGGGA KVEGIAQQLA DLKVAEKAPV AASAAPSTTE  60
   61 ADQEKKKPAL SKAERRAIQE AQRAAKAQVQ TKKAQHAAKA PPSAAPKGPN RKSVSPTTAA 120
  121 TSSSPVKC

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.35
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #3
Region A:
Residues: [226-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASTPNVDCR VKLFNHLVCA KEDSQFINDP LVHPSIARLG VQYAKRTVVG SNARCIAFLH  60
   61 ALRQVVHDFE TPAKKEFGRS LDAAVKHHVD HLHKCRPLAV SVSNAYKQFK NQLTQLPADV 120
  121 PETESKELLV HFIDTYIENQ IGKAAQAISG FLQEKITDGD VLLTFACSSL IQFICEEAKR 180
  181 RQVAFRVIVV DSRPGCEGQE LLRRLHATGI PCTYVLINAV GYVMAEATKV LLGAHALLAN 240
  241 GYVMARTGTA QVALVANAHN VPVLVCCETH KFSERFQTDA IVYNELSDPN QLVRGDKCQL 300
  301 SNWAAKGKLL PLNLSYDITP PELVSAVVTE VAILPCTSVP VILRIKPDIG Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.0
Match: 1t9kA
Description: X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 10.1099993541596 bayes_pls_golite062009
translation regulator activity 5.74669335554405 bayes_pls_golite062009
catalytic activity 1.31732715713197 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.09424756417577 bayes_pls_golite062009
nucleic acid binding 0.690575841886046 bayes_pls_golite062009
binding 0.306360407226215 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle