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Protein Overview: GlcT-1-PA

General Information:
Name(s) found: GlcT-1-PA / FBpp0071669 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene GlcT-1 is referred to in FlyBase by the symbol Dmel\GlcT-1 (CG6437, FBgn0067102). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17963547..17965177. It has the cytological map location 58B3. There is experimental evidence that it has the molecular function</span>: ceramide glucosyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of apoptosis. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 440 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDA]
    Golgi membrane [IDA]
    Biological Process: negative regulation of apoptosis [IMP]
    Molecular Function: ceramide glucosyltransferase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHLPLPLYG FAAFFMVFWL GTWMVHVIAI CYGRYKLHKK SCKLPTEAQP LPGVSILKPL  60
   61 MGVDPNLQHN LETFFTMDYP LYELLFCVED KEDPAIQLVE RLLAKYPLVD AALFVGGSDV 120
  121 GVNPKINNIH PGYMAAKYDF VMISDSGIKM KDDTLLDMVQ NMSEKHALVH QMPFTCDRDG 180
  181 FAATFEKVFF GTVQSRIYLS ADVLGINCHT GMSCLLRKAV IDQLGGLRAF GCYLAEDFFI 240
  241 ARSVTRLGWK MRISNQPALQ NSGLCDIGSF QARLIRWAKL RVAMVPTTIL LEPLSECMIL 300
  301 GAIAAWSASV LFSWDPLVFY LVHVLCWFLS DWLLLSIVQH GSMPFHKFEF VVGWLFRELT 360
  361 GPYLFLHALW NPAIRWRART YKLHWGGVAY ELNSLASDAA NDPLAPQPQP APTLEPAVVN 420
  421 AGTTGDTLIC TGAKQRLLVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..292] PSI-BLAST 24.69897 The Crystal Structure of UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferase-T1
    2 View Details [293..440] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
    		•  3.91817804237674 bayes_pls_golite062009
  • galactosyltransferase activity
    		•  3.12982459519199 bayes_pls_golite062009
  • UDP-galactosyltransferase activity
    		•  2.85902170551357 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.59060425244283 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.3653525792322 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  2.34299829327848 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  2.33328124075323 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • transferase activity
    		•  1.47184463413038 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  1.35544202600014 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.31793036737589 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.983416157001861 bayes_pls_golite062009
  • alpha-1,3-galactosyltransferase activity
    		•  0.93930146000871 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.84124932672384 bayes_pls_golite062009
  • binding
    		•  0.667238976803188 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.361674579616957 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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