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Protein Overview: PTP-ER-PA

General Information:
Name(s) found: PTP-ER-PA / FBpp0071603 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Protein tyrosine phosphatase-ERK/Enhancer of Ras1 is referred to in FlyBase by the symbol Dmel\PTP-ER (CG9856, FBgn0016641). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17506889..17511947. It has the cytological map location 57F4. There is experimental evidence that it has the molecular function</span>: protein tyrosine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: Ras protein signal transduction; mitotic cell cycle; protein amino acid dephosphorylation; R7 cell fate commitment. 9 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; eye photoreceptor cell; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1377 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: inactivation of MAPK activity [NAS]
    protein amino acid dephosphorylation [IDA][NAS]
    R7 cell fate commitment [IGI]
    Ras protein signal transduction [IGI]
    mitotic cell cycle [IMP]
    Molecular Function: protein tyrosine phosphatase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLRNNNKE NAPIEYPYPQ TPRPTHAAPS DTTPLEAGED AESNKSTPYF TPLEYLQTSF  60
   61 EFPSPTVEVG GGVPGFPEHE DQEEEVFTPR QFTITSPHPA AHVHHPSSSQ SPTLGRKFKR 120
  121 LSQYDRRSCS PHINTSSGEE RVSGRGIDKE NTMPKGGSVD QDLENSLYLS KSEHNSPTIL 180
  181 FKDESSTTPG LEASRLSYSP KLLSSINNLN VSGSPLNIIN SAGYKNGNFF RFPEIDHVVQ 240
  241 DAPMDTVCLE EATRRDRSPA LAEPPEQQQQ KSEGRKNRKN KNNLTIRITD VPIKNSSQPS 300
  301 PLPKPKTPTI KSTKEKARSL DSAANESELS IVVHNITESH GSCDDMETGQ SQPSTSVIHH 360
  361 HLHLQQPASA IHSTSLSRLD SHLSLANQRR TPRRKSPGIN TTDWLMYHRK QNPYQVQPTH 420
  421 CSSTTQSSLD SDASLTPSLG DFELKSACSV DGGSKFGIGA SLAPRSAHKH NQLLHSSSTN 480
  481 LKTLPECLTL VEFSSSGGGP KESPFKQKSM DLPMPTLQAK TTVSTSSMNL LQRRGSNHSL 540
  541 TLNLHSSCGN LMNSGLSHSN YSLGSILNSK SSCNLDAGTA SQIRADQLPQ SHLLGSSQGS 600
  601 RQGLFRRRGS NHSITLKTGH TTTSCGDLNS MQQLQQQQAM LSAEKYNRLN MRTNSTGSGS 660
  661 GSGSNVPTPK RGLLERRGSN QSLTLNMGSI LGGAAGTEIQ MTDIVQPKVT VCSCAAANQA 720
  721 PHQRKFFSTE NLNSSKANSQ KFFGQVCFGS ASDLQPNPQQ DSVREDQAIG ATCTCAGTVR 780
  781 NIMTRPLSPQ TTSEEFKIYL ASIQMLQSAS NPLNQFDLIR LNYVFDHSYQ TNRNIIEQPP 840
  841 VLGSNARDVE TPTDMVPPSS EDSELLASYQ TVVSRMAQPI PELKENEQKR IFRDLHKEFW 900
  901 DLPLNHQEKP MVFGSQTKNR YKTILPNENS RVLLESESSE LTSLLGEIKR TSSVTASEDL 960
  961 PYINANYIKG PDYVSKCYVA TQGPLPNTIF EFWLMIYQNT QRYIRRCVDG GSSSSPHVDR1020
 1021 EQILQQYFQK IVMLTNFTEA NRQKCAVYFP IELNEIFAVA AKCEVFQLSA AARDYFDRYL1080
 1081 TPTFVPDTVV ASSDAIDYEI SGRHIGVESV KVTLEGDLLE ALPAQGSFFL IKNVGIVRRN1140
 1141 GYSVRKLVLL YCIRVPQSAS YHLQKIYCYH YWYPDWPDHH SPRDINTLLD TCLHVLNLGK1200
 1201 CESEFDIYDD TRSERNAHLA AQRLEIYQQD IFNAVQPLPV IHCSAGIGRT GCFTAILNAV1260
 1261 RQLRQSLAYS LTGMLTKSLT SSSTEEYHNP TDSDSSFTCN TIRHISHILD HRDAEAVKTP1320
 1321 PSFDRLPKMP DIFVDVLGIV CNLRLQRGGM VQNSEQYELI HRAICLYLKR TLALRRF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] deduced N/A No confident structure predictions are available.
    2 View Details [163..296] deduced N/A No confident structure predictions are available.
    3 View Details [297..566] MSA 4.148997 View MSA. No confident structure predictions are available.
    4 View Details [567..695] deduced N/A No confident structure predictions are available.
    5 View Details [696..1211] PSI-BLAST 90.30103 Crystal structure of human tyrosine phosphatase SHP-1
    6 View Details [1212..1278] PSI-BLAST 89.39794 Crystal structure of the tandem phosphatase domain of RPTP CD45
    7 View Details [1279..1377] PSI-BLAST 122.0 Crystal structure of the phosphatase domains of human PTP SIGMA


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle