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Protein Overview: cpa-PA

General Information:
Name(s) found: cpa-PA / FBpp0071461 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene capping protein alpha is referred to in FlyBase by the symbol Dmel\cpa (CG10540, FBgn0034577). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16945296..16947388. It has the cytological map location 57B16. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: germarium-derived oocyte fate determination; wing disc development; regulation of lamellipodium assembly; actin cytoskeleton organization; negative regulation of actin filament polymerization; actin filament organization; phagocytosis, engulfment. 13 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; wing. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 286 amino acids

    Gene Ontology:
    Cellular Component: dynactin complex [ISS]
    F-actin capping protein complex [IEA][NAS]
    apical plasma membrane [IDA]
    Biological Process: wing disc development [IMP]
    barbed-end actin filament capping [ISS][NAS]
    regulation of lamellipodium assembly [IMP]
    phagocytosis, engulfment [IMP]
    negative regulation of actin filament polymerization [IMP]
    germarium-derived oocyte fate determination [IMP]
    actin filament organization [IMP]
    microtubule-based movement [ISS]
    actin cytoskeleton organization [IMP][NAS]
    Molecular Function: actin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQTPITDAE KVRIVSDFIL HAPPGEFNEV FNDVRELLKN DTLLKDGASH AFAQYNKDQL  60
   61 TPVRIEGTDH NAIISEHNDL GNGRFYDPRT KQAFKYDHLR KEASDYQDVE ADATAEPWRA 120
  121 ALDLETLAYT ASHYRHGVSS VFGKAQGNQI TLTICIEDHQ FQPKNYWNGR WRSQWHVTFQ 180
  181 AGSGTAELKG VLKVQVHYYE DGNVQLVSSK ECRESVVVSN EQQVAKEVIR LIEDAENEYQ 240
  241 LAISENYQTM SDTTFKAMRR QLPITRTKID WSKIVSYSIG KELKTQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..286] PSI-BLAST 136.0 Capz alpha-1 subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  6.56144513012007 bayes_pls_golite062009
  • actin filament binding
    		•  5.39928513902709 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  5.10504476256679 bayes_pls_golite062009
  • binding
    		•  2.03345990933192 bayes_pls_golite062009
  • protein binding
    		•  1.31870344025745 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle