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Protein Overview: insc-PA

General Information:
Name(s) found: insc-PA / FBpp0071490 [FlyBase]
Description(s) found:
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  • gi|7291194|gb|AAF46626.1| inscuteable [Drosophila melanogaster] [NCBI NR]
  • gi|17136972|ref|NP_477024.1| inscuteable [Drosophila melanogaster] [NCBI NR]
  • The gene inscuteable is referred to in FlyBase by the symbol Dmel\insc (CG11312, FBgn0011674). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:16708771..16723569. It has the cytological map location 57B3. There is experimental evidence that it has the molecular function</span>: cytoskeletal adaptor activity; protein binding. There is experimental evidence that it is involved in the biological process</span>: RNA localization; protein localization; somatic muscle development; establishment of mitotic spindle localization; asymmetric neuroblast division; apical protein localization; peripheral nervous system development. 70 alleles are reported. The phenotypes of these alleles are annotated with 177 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; abdominal oblique muscle; abdominal transverse muscle; larval abdominal segment 5; peripheral nervous system; nervous system; hypodermal muscle of metathorax; adult abdominal myoblast; abdominal segment 7. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG11312-PA translation from_gene[CG11312 insc FBgn0011674] seq_release:3 mol_weight=95021 cds_boundaries:(2R:15,865,755..15,869,094[-]) aa_length:859 transcript_info:[CG11312-RA seq_release:3] gene_info:[gene symbol:insc FBgn0011674 gene_boundaries:(2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W2R4) INSC protein [DrosMelano7227.FASTAC.txt]
  • (AE003452) insc gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG11312-PA [Drosophila melanogaster]gi|17136972|ref|NP_477024.1| CG11312-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(16709713..16710267,16710697..16712472,16712807..16713055); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB [fly-100309-contam.fasta]
  • inscuteable CG11312-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG11312-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(16709713..16710267,16710697..16712472,16712807..16713055); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(16709713..16710267,16710697..16712472,16712807..16713055); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Inscuteable OS=Drosophila melanogaster GN=insc PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(16709713..16710267,16710697..16712472,16712807..16713055); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626,FlyMine:FBpp0071490,modMine:FBpp0071490; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Inscuteable OS=Drosophila melanogaster GN=insc PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:complement(join(20825302..20825550,20823192..20824967,20822208..20822762)); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626,FlyMine:FBpp0071490,modMine:FBpp0071490; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(20825302..20825550,20823192..20824967,20822208..20822762)); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626,FlyMine:FBpp0071490,modMine:FBpp0071490; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0071490 type=protein; loc=2R:complement(join(20825302..20825550,20823192..20824967,20822208..20822762)); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626,FlyMine:FBpp0071490,modMine:FBpp0071490; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(20825302..20825550,20823192..20824967,20822208..20822762)); ID=FBpp0071490; name=insc-PA; parent=FBgn0011674,FBtr0071562; dbxref=FlyBase:FBpp0071490,FlyBase_Annotation_IDs:CG11312-PA,GB_protein:AAF46626.1,REFSEQ:NP_477024,GB_protein:AAF46626,UniProt/TrEMBL:Q9W2R4,FlyMine:FBpp0071490,modMine:FBpp0071490; MD5=5239c25b90e415bd1fab2a0893ce3c25; length=859; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 859 amino acids

    Gene Ontology:
    Cellular Component: apical part of cell [NAS]
    cytoplasm [IDA]
    cell cortex [IDA]
    apical cortex [IDA][TAS]
    Biological Process: cytoskeleton organization [NAS]
    establishment of mitotic spindle localization [IMP][NAS][TAS]
    protein localization [IMP][NAS]
    peripheral nervous system development [IMP]
    neuroblast fate determination [TAS]
    asymmetric cell division [TAS]
    somatic muscle development [IMP]
    RNA localization [IMP]
    sensory organ development [TAS]
    asymmetric protein localization [TAS]
    asymmetric protein localization involved in cell fate determination [NAS][TAS]
    basal protein localization [TAS]
    apical protein localization [IMP][IPI]
    asymmetric neuroblast division [IGI][TAS]
    Molecular Function: cytoskeletal adaptor activity [IMP][ISS][NAS]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFQRSYSKV WWGSEQSSLT SGGFYSSFSG GSSTSSTSNY PQRQPASLGP LGNLSCIQEV  60
   61 EDEQNSSKLS WHKHDSPGSL RSQDSGFSDN EESHQLQHQQ NLSPPSPQSD KQQTPAATPT 120
  121 SVHSVATPPT VVRRVGNSSF YSPLISVTRR ISFTSGQITP KTRSGDEDAE DAELEASRSR 180
  181 LFEQLDSMKL DDGEAEAEED SPPRPAIRRR RRLMRKPMPE PEAASASEEE EVVIAPPPPP 240
  241 PYNNETVYLG EAPPPYNNET VTFGATEQDE SLQQQPSPLR VRSLRFTAST STPKSGSKIA 300
  301 KRGKKHPEPV ASWMSEQRWA GEPEVMCTLQ HKSIAQEAYK NYTITTSAVC KLVRQLQQQA 360
  361 LSLQVHFERS ERVLSGLQAS SLPEALAGAT QLLSHLDDFT ATLERRGVFF NDAKIERRRY 420
  421 EQHLEQIRTV SKDTRYSLER QHYINLESLL DDVQLLKRHT LITLRLIFER LVRVLVISIE 480
  481 QSQCDLLLRA NINMVATLMN IDYDGFASLS DAFVQNEAVR TLLVVVLDHK QSSVRALALR 540
  541 ALATLCCAPQ AINQLGSCGG IEIVRDILQV ESAGERGAIE RREAVSLLAQ ITAAWHGSEH 600
  601 RVPGLRDCAE SLVAGLAALL QPECCTQTLL LCAAALNNLS RMEATSHYSI MSNEAIFRLI 660
  661 DTLEHQTCGT SVFLYEQIVG MLHNMSLNKK CHSHLANGVI INFITSVYQT EFYQTYGSRA 720
  721 ESDAQRRTIK TILHTLTRLA SDSPTLGAEL LEQWHLPDLL RQSLALKPAN SQQQQHLDSS 780
  781 YGGDISQLAR QLLRAHGQEQ QLLQATPAPG GSFSSGHQTP EAQTQTNSSG MSSSGSKTKA 840
  841 KSSASPLLKF NLTRQESFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..249] MSA 4.236996 View MSA. No confident structure predictions are available.
    2 View Details [250..398] MSA 1.214991 View MSA. No confident structure predictions are available.
    3 View Details [399..447] deduced N/A No confident structure predictions are available.
    4 View Details [448..859] FFAS03 2.05 No description for 2gl7A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  2.83587618361842 bayes_pls_golite062009
  • actin binding
    		•  2.29138393912024 bayes_pls_golite062009
  • binding
    		•  2.17307898957054 bayes_pls_golite062009
  • protein binding
    		•  1.63424405980235 bayes_pls_golite062009
  • protein transporter activity
    		•  1.56169561103687 bayes_pls_golite062009
  • RNA binding
    		•  1.24761758796616 bayes_pls_golite062009
  • transporter activity
    		•  1.08134399163505 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.65168535727044 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle