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Protein Overview: Fak56D-PC, Fak56...

General Information:
Name(s) found: Fak56D-PG / FBpp0291097 [FlyBase]
Fak56D-PC / FBpp0085728 [FlyBase]
Fak56D-PB / FBpp0085727 [FlyBase]
Fak56D-PA / FBpp0085726 [FlyBase]
Description(s) found:
Found 51 descriptions.
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  • The gene Focal Adhesion Kinase is referred to in FlyBase by the symbol Dmel\Fak56D (CG10023, FBgn0020440). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15318164..15324774. It has the cytological map location 56D5. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape. 11 alleles are reported. The phenotypes of these alleles are annotated with: larval optic stalk; subretinal glial cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Focal Adhesion Kinase is referred to in FlyBase by the symbol Dmel\Fak56D (CG10023, FBgn0020440). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15318164..15324774. It has the cytological map location 56D5. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape. 11 alleles are reported. The phenotypes of these alleles are annotated with: larval optic stalk; subretinal glial cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Focal Adhesion Kinase is referred to in FlyBase by the symbol Dmel\Fak56D (CG10023, FBgn0020440). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15318164..15324774. It has the cytological map location 56D5. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape. 11 alleles are reported. The phenotypes of these alleles are annotated with: larval optic stalk; subretinal glial cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Focal Adhesion Kinase is referred to in FlyBase by the symbol Dmel\Fak56D (CG10023, FBgn0020440). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15318164..15324774. It has the cytological map location 56D5. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape. 11 alleles are reported. The phenotypes of these alleles are annotated with: larval optic stalk; subretinal glial cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1200 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    focal adhesion [IEA][ISS]
    Biological Process: regulation of cell shape [IMP]
    signal complex assembly [IEA]
    integrin-mediated signaling pathway [ISS]
    protein amino acid phosphorylation [IEA][NAS]
    cytoskeletal anchoring at plasma membrane [ISS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IEA][ISS][NAS]
    protein binding [IEA]
    non-membrane spanning protein tyrosine kinase activity [ISS]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTAGATSQP PPTKNEINSE EYLIHVHMPN KSFKAVRFNV KETVFHVIRR TVEDLGTDGR  60
   61 TPSIQRYACR MLNMITKEVI WLARSTSMQK VLSHILTPGC SNVDCPNNQS ELDEVLLEHG 120
  121 RRITDNRVWR VELRVRYVPN NIQELFEEDK ATCFYYFNQV KEDFIQANVT AIDTEVAVQL 180
  181 CCLGIRHYFK NITVKAPDKK QHIDYIEKEI GFKSFLPQSV IATSKPKNLK KLIQVGYKKV 240
  241 YNYNDIEYLT RFFDLLKNIY LTNFEQFSVT LSSAWNISGI LHVGPHIGIS YQTHPQASLK 300
  301 NVAQFKDVVS IKTCTLPKEK LSKSGENTTE PELQNFNCNC QKIKTQIKIS ASNNVEDLVI 360
  361 TCNGINTAES IADLIDGYCR LLSKDLEFTI WHRETNASNE DSAKALPNDA TLGSNKSTSS 420
  421 QGKPMLTDDY AEIGLLEGEG DYSTPTVRNY ELDRALITPS AKIGVGQFGD VYVGTYTLPK 480
  481 LGKGKNLAGN GKNSNSDQRN ADSRPDVIQV AIKTCKANDD PEKTENFLAE AYIMQKFDHP 540
  541 HIIRLIGICS VMPIWIVMEL AKLGELRAYL KTNSERLSHG TLLKYCYQLS TALSYLESKK 600
  601 FVHRDIAARN VLVSSPTCVK LADFGLSRWV SDQSYYHSTP TVALPIKWMS PESINFRRFT 660
  661 TASDVWMFGV CIWEILMLGV KPFQGVKNSD VILKLENGER LPLPPNCPPR LYSLMSQCWA 720
  721 YEPLKRPNFK RIKETLHEIL IEDSINSSET LKREQRKVAS MSWIGSDDID IPPSKPSRVM 780
  781 HDPDITGLMP ETTGLPQTYI IAQNPAVLAK LMMENQKRGI NPAAYTTPAS GIHNVLGEKL 840
  841 RQQQKDSNSD SEWLIQEELL RQRSCSIPQG SLNDHQAQMF KLDFMSAGPS SLPDCSNSSS 900
  901 RPMTPNANLS SLKSNHSSAD HLSSLTSAEE QMGSNARNLG SAVPSRPPNR ADDEVYCATT 960
  961 LVVKSIMALS QGVEKANTEG YLELVKNVGV KLRNLLTSVD KISIIFPAQA LKEVQMAHQV1020
 1021 LSKDMHELVS AMRLAQQYSD TTLDCEYRKS MLSAAHVLAM DAKNLFDVVD SIRQRYQHLF1080
 1081 PPSATKETSC SSSFESTSGS IVAEPVNDLG GYIKTSTSGD LLQNTGIYDN DLHHSFNSQL1140
 1141 QLQNPKASID LSGGGSLQRG MSLGLDTTRS TNEPLRIVEE TLGSPGEHMY CNTSALHGHA1200
 1201

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..750] PSI-BLAST 169.0 No description for 2j0jA was found.
    2 View Details [751..829] PSI-BLAST 72.154902 No description for 2qoqA was found.
    3 View Details [830..905] deduced N/A No confident structure predictions are available.
    4 View Details [906..1125] PSI-BLAST 42.39794 FAT domain of focal adhesion kinase
    5 View Details [1126..1200] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle