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Protein Overview: Topors-PA, FBpp0...

General Information:
Name(s) found: FBpp0304302 [FlyBase]
Topors-PA / FBpp0085754 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=2R:join(14860832..14861227,14861288..14861748,14861816..14863230,14863398..14864242); ID=FBpp0304302; name=Topors-PB; parent=FBgn0034410,FBtr0331977; dbxref=FlyBase:FBpp0304302,FlyBase_Annotation_IDs:CG15104-PB,REFSEQ:NP_001261083,GB_protein:AGB93615; MD5=b6520c664b5605e9aa4272d8a0134bf2; length=1038; release=r5.56; species=Dmel; [FlyBase]
  • The gene Topoisomerase I-interacting protein is referred to in FlyBase by the symbol Dmel\Topors (CG15104, FBgn0034410). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14860449..14864767. It has the cytological map location 56A2. There is experimental evidence that it has the molecular function</span>: ubiquitin-protein ligase activity. The biological processes in which it is involved are not known. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1038 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome [IDA]
    nucleus [IDA]
    nuclear lamina [IDA]
    Biological Process: NONE FOUND
    Molecular Function: ubiquitin-protein ligase activity [IDA]
    zinc ion binding [IEA]
    DNA topoisomerase I binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEENPGALA ANVPYLGVDE LGASVIVEPG LEGSNAGGRT LPAAAIKFAD LTESGSESGD  60
   61 NEAEEPVSAG PDNANAIGEP GTSASAAEEN GTVERNSPPP NCAICLSRCR RKCFTDSCMH 120
  121 QFCFKCLCEW SKIKPECPLC KQPFRTIIHN VRTLDDYDRY PVQTTSPVPT ENPSLRYHIV 180
  181 RRPRYTPLVQ NQAVIVNDIE AAIAAGAAGE DVLSAAEVAA GRRSYSRFEP YRSELMNYYQ 240
  241 HDQDASTSGS LSQLWRRYVY DRKLYALPVS DSVTGHFREW SARFYRNNPA QIHRLMPWIH 300
  301 RDIMCLLRNA AHSVNTVMTL MSDLLPMTSL LGPTFRRRLS PYLGERTSHF IHELFNFARS 360
  361 PYDINGYDHV VQYSARVAEE VEVDLLDMVE TQSSNGDDLN LEVGDSDADA INAGFSPDWS 420
  421 PPRVRPSTSV IVTNPGATHS FSVTMASDGS ELPGISIRRT TNVGSQTVAI NLSMRRPAAV 480
  481 ASEEPEVIEI DDGDAAANAE VAAINDGSNT SRRHAGATLP VTAHIELESS SSSGDEDECV 540
  541 FVLELKPPHM RTPEQVSLDS NSDSDVVFVN EQHEAAPDAI AENRSTQSPL DLASRDQGLF 600
  601 MGPSTSGAAA NRGKNWKLVM AQTRRLDQLR TLRSIRSKKS RRSSMPARSD SGSSPSSCSS 660
  661 SSFHFSSSSD EDSSDSSTTN SEPPKKKSRK RVANNKRSKK ESIGKRTSRK RKAKDQNMEM 720
  721 LEQQQISQKK PQRQPESSSD SPSSSDDESG GDSSESSGQP NTNNNKSSSD SDDDSAVNMQ 780
  781 LSALRATLKA EATLEDRKPV KLELQLPDDD QAGPLHSRMT PSPREDNEPG CSAPKRRRSC 840
  841 SHSNQSSQSA SLASSSTATS SSAPLSSFAW GAAGFSGDPL MRGHPAMEEH DIANSLIELS 900
  901 TLTQPVNIGL FNEHYNSAEN SMGMLSNTLC DSPQTLAADD ANLENYFDTD ADPEASRERD 960
  961 AYSLEAAIDV VGESELQIAE DTATATEEQD EEDEEDEDQE EDDQEEEKAA EEEEEEEEDD1020
 1021 DDSDNHDEND ENQGLLPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] deduced N/A No confident structure predictions are available.
    2 View Details [87..213] PSI-BLAST 17.522879 No description for 2cklA was found.
    3 View Details [214..280] deduced N/A No confident structure predictions are available.
    4 View Details [281..360] FFAS03 0.965 Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein Prp3(hPrp3)
    5 View Details [361..418] deduced N/A No confident structure predictions are available.
    6 View Details [419..469] deduced N/A No confident structure predictions are available.
    7 View Details [470..604] deduced N/A No confident structure predictions are available.
    8 View Details [605..843] deduced N/A No confident structure predictions are available.
    9 View Details [844..907] deduced N/A No confident structure predictions are available.
    10 View Details [908..1038] FFAS03 1.18 30S subunit


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle