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Protein Overview: Hsf-PA

General Information:
Name(s) found: Hsf-PA / FBpp0085961 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Heat shock factor is referred to in FlyBase by the symbol Dmel\Hsf (CG5748, FBgn0001222). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14017808..14022136. It has the cytological map location 55B7-55B8. There is experimental evidence that it has the molecular function</span>: specific RNA polymerase II transcription factor activity; transcription activator activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; response to heat. 89 alleles are reported. The phenotypes of these alleles are annotated with: polytene chromosome; egg chamber; nurse cell. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 691 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    polytene chromosome [IDA]
    Biological Process: response to heat [IDA][NAS][TAS]
    regulation of transcription, DNA-dependent [IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    Molecular Function: DNA binding [IDA][IEP][NAS][TAS]
    transcription factor activity [IEA]
    specific RNA polymerase II transcription factor activity [IDA][ISS]
    sequence-specific DNA binding [IEA]
    transcription activator activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSRSSAKA VQFKHESEEE EEDEEEQLPS RRMHSYGDAA AIGSGVPAFL AKLWRLVDDA  60
   61 DTNRLICWTK DGQSFVIQNQ AQFAKELLPL NYKHNNMASF IRQLNMYGFH KITSIDNGGL 120
  121 RFDRDEIEFS HPFFKRNSPF LLDQIKRKIS NNKNGDDKGV LKPEAMSKIL TDVKVMRGRQ 180
  181 DNLDSRFSAM KQENEVLWRE IASLRQKHAK QQQIVNKLIQ FLITIVQPSR NMSGVKRHVQ 240
  241 LMINNTPEID RARTTSETES ESGGGPVIHE LREELLDEVM NPSPAGYTAA SHYDQESVSP 300
  301 PAVERPRSNM SISSHNVDYS NQSVEDLLLQ GNGTAGGNIL VGGAASPMAQ SVSQSPAQHD 360
  361 VYTVTEAPDS HVQEVPNSPP YYEEQNVLTT PMVREQEQQK RQQLKENNKL RRQAGDVILD 420
  421 AGDILVDSSS PKAQRTSIQH STQPDVMVQP MIIKSEPENS SGLMDLMTPA NDLYSVNFIS 480
  481 EDMPTDIFED ALLPDGVEEA AKLDQQQKFG QSTVSSGKFA SNFDVPTNST LLDANQASTS 540
  541 KAAAKAQASE EEGMAVAKYS GAENGNNRDT NNSQLLRMAS VDELHGHLES MQDELETLKD 600
  601 LLRGDGVAID QNMLMGLFND SDLMDNYGLS FPNDSISSEK KAPSGSELIS YQPMYDLSDI 660
  661 LDTDDGNNDQ EASRRQMQTQ SSVLNTPRHE L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 39.69897 SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
    2 View Details [149..249] Pfam 10.102373 No description for PF00447.8 was found. No confident structure predictions are available.
    3 View Details [250..355] deduced N/A No confident structure predictions are available.
    4 View Details [356..526] MSA 9.239996 View MSA. No confident structure predictions are available.
    5 View Details [527..691] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle