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Protein Overview: grh-PJ

General Information:
Name(s) found: grh-PJ / FBpp0288984 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene grainy head is referred to in FlyBase by the symbol Dmel\grh (CG42311, FBgn0259211). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13690294..13729118. It has the cytological map location 54E10-54F1. There is experimental evidence that it has the molecular function</span>: specific RNA polymerase II transcription factor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; nervous system development; tracheal outgrowth, open tracheal system; regulation of cell proliferation; open tracheal system development; regulation of tube length, open tracheal system; plasma membrane organization; chitin-based embryonic cuticle biosynthetic process. 70 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; embryonic/larval tracheal system; cephalopharyngeal skeleton; portion of tissue; cuticle; adult segment; adult mesothoracic segment; adult neuroblast; embryonic dorsal branch; embryonic/larval visceral branch; embryonic dorsal trunk; wing hair; embryonic tracheal system; embryonic ganglionic branch; plasma membrane part. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1333 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: regulation of cell shape [IMP]
    chitin-based embryonic cuticle biosynthetic process [IMP]
    regulation of tube architecture, open tracheal system [TAS]
    nervous system development [IMP]
    tracheal outgrowth, open tracheal system [IMP]
    regulation of cell proliferation [IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    open tracheal system development [IEP][TAS]
    ganglion mother cell fate determination [TAS]
    ventral cord development [NAS]
    plasma membrane organization [IMP]
    primary branching, open tracheal system [TAS]
    cellular membrane organization [TAS]
    regulation of tube length, open tracheal system [IMP]
    Molecular Function: DNA binding [IDA]
    RNA polymerase II transcription factor activity [NAS]
    specific RNA polymerase II transcription factor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSTATTSV ITSNELSLSG HAHGHGHAHQ LHQHTHSRLG VGVGVGILSD ASLSPIQQGS  60
   61 GGHSGGGNTN SSPLAPNGVP LLTTMHRSPD SPQPELATMT NVNVLDLHTD NSKLYDKEAV 120
  121 FIYETPKVVM PADGGGGNNS DEGHAIDARI AAQMGNQAQQ QQQQQQQTEH QPLAKIEFDE 180
  181 NQIIRVVGPN GEQQQIISRE IINGEHHILS RNEAGEHILT RIVSDPSKLM PNDNAVATAM 240
  241 YNQAQKMNND HGQAVYQTSP LPLDASVLHY SGGNDSNVIK TEADIYEDHK KHAAAAAAAA 300
  301 GGGSIIYTTS DPNGVNVKQL PHLTVPQKLD PDLYQADKHI DLIYNDGSKT VIYSTTDQKS 360
  361 LEIYSGGDIG SLVSDGQVVV QAGLPYATTT GAGGQPVYIV ADGALPAGVE EHLQSGKLNG 420
  421 QTTPIDVSGL SQNEIQGFLL GSHPSSSATV STTGVVSTTT ISHHQQQQQQ QQQQQQQQQQ 480
  481 QHQQQQQHPG DIVSAAGVGS TGSIVSSAAQ QQQQQQLISI KREPEDLRKD PKNGNIAGAA 540
  541 TANGPGSVIT QKILHVDAPT ASEADRPSTP SSSINSTENT ESDSQSVSGS ESGSPGARTT 600
  601 ATLEMYATTG GTQIYLQTSH PSTASGAGGG AGPAGAAGGG GVSMQAQSPS PGPYITANDY 660
  661 GMYTASRLPP GPPPTSTTTF IAEPSYYREY FAPDGQGGYV PASTRSLYGD VDVSVSQPGG 720
  721 VVTYEGRFAG SVPPPATTTV LTSVHHHQQQ QQQQQQHQQQ QQQQQHHQQQ QHHSQDGKSN 780
  781 GGATPLYAKA ITAAGLTVDL PSPDSGIGTD AITPRDQTNI QQSFDYTELC QPGTLIDANG 840
  841 SIPVSVNSIQ QRTAVHGSQN SPTTSLVDTS TNGSTRSRPW HDFGRQNDAD KIQIPKIFTN 900
  901 VGFRYHLESP ISSSQRREDD RITYINKGQF YGITLEYVHD AEKPIKNTTV KSVIMLMFRE 960
  961 EKSPEDEIKA WQFWHSRQHS VKQRILDADT KNSVGLVGCI EEVSHNAIAV YWNPLESSAK1020
 1021 INIAVQCLST DFSSQKGVKG LPLHVQIDTF EDPRDTAVFH RGYCQIKVFC DKGAERKTRD1080
 1081 EERRAAKRKM TATGRKKLDE LYHPVTDRSE FYGMQDFAKP PVLFSPAEDM EKVGQLGIGA1140
 1141 ATGMTFNPLS NGNSNSNSHS SLQSFYGHET DSPDLKGASP FLLHGQKVAT PTLKFHNHFP1200
 1201 PDMQTDKKDH ILDQNMLTST PLTDFGPPMK RGRMTPPTSE RVMLYVRQEN EEVYTPLHVV1260
 1261 PPTTIGLLNA IENKYKISTT SINNIYRTNK KGITAKIDDD MISFYCNEDI FLLEVQQIED1320
 1321 DLYDVTLTEL PNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] deduced N/A No confident structure predictions are available.
    2 View Details [237..428] MSA 1.213995 View MSA. No confident structure predictions are available.
    3 View Details [429..597] MSA 2.241986 View MSA. No confident structure predictions are available.
    4 View Details [598..704] MSA 5.246987 View MSA. No confident structure predictions are available.
    5 View Details [705..856] deduced N/A No confident structure predictions are available.
    6 View Details [857..938] deduced N/A No confident structure predictions are available.
    7 View Details [939..1096] deduced N/A No confident structure predictions are available.
    8 View Details [1097..1220] deduced N/A No confident structure predictions are available.
    9 View Details [1221..1333] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.53

    Source: Reynolds et al. (2008)

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