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Protein Overview: POSH-PA

General Information:
Name(s) found: POSH-PA / FBpp0086007 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Plenty of SH3s is referred to in FlyBase by the symbol Dmel\POSH (CG4909, FBgn0040294). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13456243..13459827. It has the cytological map location 54C9. There is experimental evidence that it has the molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: protein localization; determination of adult lifespan; pole plasm oskar mRNA localization; oocyte microtubule cytoskeleton polarization; rhabdomere development. 12 alleles are reported. The phenotypes of these alleles are annotated with: eye; macrochaeta; genitalia; tarsal segment; wing; melanotic mass; wing hair. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 838 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: rhabdomere development [IMP]
    determination of adult lifespan [IMP][NAS]
    pole plasm oskar mRNA localization [IMP]
    protein localization [IMP]
    oocyte microtubule cytoskeleton polarization [IMP]
    Molecular Function: ubiquitin-protein ligase activity [IDA]
    zinc ion binding [IEA]
    protein binding [IEA]
    receptor signaling complex scaffold activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEHTLNDLL ECSVCLERLD TTSKVLPCQH TFCRKCLQDI VASQHKLRCP ECRILVSCKI  60
   61 DELPPNVLLM RILEGMKQNA AAGKGEEKGE ETETQPERAK PQPPAESVAP PDNQLLQLQS 120
  121 HQQSHQPARH KQRRFLLPHA YALFDFASGE ATDLKFKKGD LILIKHRIDN NWFVGQANGQ 180
  181 EGTFPINYVK VSVPLPMPQC IAMYDFKMGP NDEEGCLEFK KSTVIQVMRR VDHNWAEGRI 240
  241 GQTIGIFPIA FVELNAAAKK LLDSGLHTHP FCHPPKQQGQ RALPPVPVID PTVVTESSSG 300
  301 SSNSTPGSSN SSSTSSSNNC SPNHQISLPN TPQHVVASGS ASVRFRDKGA KEKRHSLNAL 360
  361 LGGGAPLSLL QTNRHSAEIL SLPHELSRLE VSSSTALKPT SAPQTSRVLK TTVQQQMQPN 420
  421 LPWGYLALFP YKPRQTDELE LKKGCVYIVT ERCVDGWFKG KNWLDITGVF PGNYLTPLRA 480
  481 RDQQQLMHQW KYVPQNADAQ MAQVQQHPVA PDVRLNNMLS MQPPDLPPRQ QQATATTTSC 540
  541 SVWSKPVEAL FSRKSEPKPE TATASTTSSS SSGAVGLMRR LTHMKTRSKS PGASLQQVPK 600
  601 EAISTNVEFT TNPSAKLHPV HVRSGSCPSQ LQHSQPLNET PAAKTAAQQQ QFLPKQLPSA 660
  661 STNSVSYGSQ RVKGSKERPH LICARQSLDA ATFRSMYNNA ASPPPPTTSV APAVYAGGQQ 720
  721 QVIPGGGAQS QLHANMIIAP SHRKSHSLDA SHVLSPSSNM ITEAAIKASA TTKSPYCTRE 780
  781 SRFRCIVPYP PNSDIELELH LGDIIYVQRK QKNGWYKGTH ARTHKTGLFP ASFVEPDC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] PSI-BLAST 11.09691 No description for 2egpA was found.
    2 View Details [131..479] FFAS03 5.33 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
    3 View Details [480..612] deduced N/A No confident structure predictions are available.
    4 View Details [613..838] PSI-BLAST 10.0 NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.52774929405779 bayes_pls_golite062009
  • protein binding
    		•  1.28384864078887 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.890565712002955 bayes_pls_golite062009
  • actin binding
    		•  0.00539984922981329 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle