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Protein Overview: Syn2-PC

General Information:
Name(s) found: Syn2-PC / FBpp0086242 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Syntrophin-like 2 is referred to in FlyBase by the symbol Dmel\Syn2 (CG4905, FBgn0034135). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12439765..12445988. It has the cytological map location 53C7. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of muscle; cytoskeletal protein binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 459 amino acids

    Gene Ontology:
    Cellular Component: syntrophin complex [ISS][NAS]
    Biological Process: NONE FOUND
    Molecular Function: structural constituent of muscle [ISS]
    protein binding [IEA]
    cytoskeletal protein binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSDTMATP IEEKLDQNLK VRTGMVHVSD GKSRPEPLRL NLTMELLSLQ KLEVVTPSSC  60
   61 HPNGPPMESK ERMVQITRQK QGGLGLSIKG GAEHKLPILI SRIYKDQAAD ITGQLFVGDA 120
  121 IIKVNGEYIT ACPHDDAVNI LRNAGDIVVL TVKHYRAATP FLQKQLPLMM AYVTRYIYGT 180
  181 DKLRQNAFEV RGLNGISTGV IHCDELAILS QWLKLITDNV VGLTHLQMKL YNRNFAVGER 240
  241 IEYMGWVNEG VINNNISWQS YKPRFLLLKG TEVMLFETPP LNVAGISKAL VVYKVYQTMF 300
  301 RIVKESETVD SRQHCFLLQS SGHEPRYLSV ETRQELLRIE NSWNAAIVTS VIKLGRKTFA 360
  361 VSHHGKSGGL TLDWQAGFSL TEGAESATVW QYKFSQLRGS SDDGKSKLKL HFQDHDSRAI 420
  421 ETKELECQVL QSLLFCMHAF LTAKVASVDP AFLSSIQQT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] PSI-BLAST 26.09691 solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
    2 View Details [70..172] PSI-BLAST 12.30103 Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains
    3 View Details [173..459] PSI-BLAST 16.0 Psd-95; Guanylate kinase-like domain of Psd-95

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • acetylcholine transmembrane transporter activity
    		•  5.06834908423057 bayes_pls_golite062009
  • binding
    		•  2.4211406884996 bayes_pls_golite062009
  • protein binding
    		•  2.25893018754605 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.20288049012953 bayes_pls_golite062009
  • transporter activity
    		•  1.18978519116375 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07211582292329 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.87883331498113 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.877891218909175 bayes_pls_golite062009
  • signal transducer activity
    		•  0.877891218909175 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.83498428286086 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.766679710300835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.755223974149211 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.64214865642772 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.549085929250683 bayes_pls_golite062009
  • calcium channel regulator activity
    		•  0.400074937231358 bayes_pls_golite062009
  • receptor binding
    		•  0.359972518335054 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252733105474942 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle