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View Structure Prediction Details

Protein: Syn2-PC
Organism: Drosophila melanogaster
Length: 459 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Syn2-PC.

Description E-value Query
Range
Subject
Range
gi|10442636 - gi|10442636|gb|AAG17398.1|AF277389_1 gamma-syntrophin-like protein SYN2 [Drosophila melanogaster]
410.0 [0..1] [459..1]

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Predicted Domain #1
Region A:
Residues: [1-69]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSDTMATP IEEKLDQNLK VRTGMVHVSD GKSRPEPLRL NLTMELLSLQ KLEVVTPSSC  60
   61 HPNGPPMES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.09691
Match: 1z87A
Description: solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [70-172]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KERMVQITRQ KQGGLGLSIK GGAEHKLPIL ISRIYKDQAA DITGQLFVGD AIIKVNGEYI  60
   61 TACPHDDAVN ILRNAGDIVV LTVKHYRAAT PFLQKQLPLM MAY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.30103
Match: 1u3bA
Description: Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetylcholine transmembrane transporter activity 5.06834908423057 bayes_pls_golite062009
binding 2.4211406884996 bayes_pls_golite062009
protein binding 2.25893018754605 bayes_pls_golite062009
structural constituent of muscle 1.20288049012953 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
PDZ domain binding 0.87883331498113 bayes_pls_golite062009
molecular transducer activity 0.877891218909175 bayes_pls_golite062009
signal transducer activity 0.877891218909175 bayes_pls_golite062009
ErbB-2 class receptor binding 0.83498428286086 bayes_pls_golite062009
amine transmembrane transporter activity 0.766679710300835 bayes_pls_golite062009
substrate-specific transporter activity 0.755223974149211 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.549085929250683 bayes_pls_golite062009
calcium channel regulator activity 0.400074937231358 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [173-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTRYIYGTDK LRQNAFEVRG LNGISTGVIH CDELAILSQW LKLITDNVVG LTHLQMKLYN  60
   61 RNFAVGERIE YMGWVNEGVI NNNISWQSYK PRFLLLKGTE VMLFETPPLN VAGISKALVV 120
  121 YKVYQTMFRI VKESETVDSR QHCFLLQSSG HEPRYLSVET RQELLRIENS WNAAIVTSVI 180
  181 KLGRKTFAVS HHGKSGGLTL DWQAGFSLTE GAESATVWQY KFSQLRGSSD DGKSKLKLHF 240
  241 QDHDSRAIET KELECQVLQS LLFCMHAFLT AKVASVDPAF LSSIQQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.0
Match: 1kjwA
Description: Psd-95; Guanylate kinase-like domain of Psd-95
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle