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Protein Overview: eIF2B-gamma-PA

General Information:
Name(s) found: eIF2B-gamma-PA / FBpp0086469 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene eIF2B-Ã?&#142;Ã?³ is referred to in FlyBase by the symbol Dmel\eIF2B-Ã?&#142;Ã?³ (CG8190, FBgn0034029). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11430175..11431922. It has the cytological map location 52A10. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity; translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS][NAS]
    eukaryotic translation initiation factor 2B complex [ISS][NAS]
    Biological Process: translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]
    nucleotidyltransferase activity [IEA]
    guanyl-nucleotide exchange factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEFQAVVFA AGRGTRLPEV LGDAPKCLLP VGPYPLIWYP LNLLQQHNFT EVIVVVLEQE  60
   61 KLEIQSALEN TPLKLRLDYA TIPSDGDFGT ADSLRYIYDK IKSDFLVVSC DLVSNVSLYP 120
  121 LINKFREHDA ALAMLLFPSG FESDVVMPGP KSKHKPERDL IGIHAATQRL AFVSAASDCE 180
  181 ETLNIQRHLL KNRGRLDVYS RLVDAHVYVL KKWVIDYLRR KENISTFKGE FLPHLIKKQH 240
  241 SKRPPKTVQD TTSEVGVVTK NEDHVLHYVG HTILDQKITQ TSLFNQSLSQ SPYHGDIVRC 300
  301 YGIQAPRDAI GVRVNNTLSF LAINRKLASI WNNLCGEKHP LISPGAVVKS TQTKEIIAAD 360
  361 NAKLSEKTSL NFSVFGPNCI ISPKNIVANS LIMSNAIVEE GCNIDNCIIG HRAQVKSGSV 420
  421 LKNCIIGPNY VVEEGTHSQA VHLSNADQFM EIDIQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..455] PSI-BLAST 61.09691 N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity
    		•  2.17535315350752 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.86990263440735 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.49149681135671 bayes_pls_golite062009
  • glucose binding
    		•  1.05456452815784 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.796949457473955 bayes_pls_golite062009
  • acyltransferase activity
    		•  0.741838450922005 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  0.717805296858439 bayes_pls_golite062009
  • binding
    		•  0.667238976803188 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  0.619458068514795 bayes_pls_golite062009
  • sugar binding
    		•  0.598232027709749 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.555398952276587 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.319932817519902 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle