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Protein Overview: FBpp0308981, O-f...

General Information:
Name(s) found: FBpp0308981 [FlyBase]
O-fut1-PA / FBpp0086649 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=2R:join(10048968..10049085,10049141..10050231); ID=FBpp0308981; name=O-fut1-PB; parent=FBgn0033901,FBtr0339959; dbxref=FlyBase:FBpp0308981,FlyBase_Annotation_IDs:CG12366-PB; MD5=e1a21e8e3c07d1d205a9025dd98470c2; length=402; release=r5.56; species=Dmel; [FlyBase]
  • The gene O-fucosyltransferase 1 is referred to in FlyBase by the symbol Dmel\O-fut1 (CG12366, FBgn0033901). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10048940..10050326. It has the cytological map location 50E1. There is experimental evidence that it has the molecular function</span>: Notch binding; fucosyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; endocytosis; regulation of Notch signaling pathway; cell-cell adhesion; nervous system development; protein catabolic process. 31 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; leg; eye; S2 cell-line; wing; wing vein. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 402 amino acids

    Gene Ontology:
    Cellular Component: integral to Golgi membrane [ISS]
    cytoplasmic vesicle [IDA]
    endoplasmic reticulum [IDA]
    [NOT]Golgi apparatus [IDA]
    Biological Process: cell-cell adhesion [IMP]
    protein amino acid O-linked glycosylation [ISS]
    regulation of Notch signaling pathway [IMP]
    protein catabolic process [IMP]
    nervous system development [IMP]
    negative regulation of Notch signaling pathway [IMP]
    endocytosis [IMP]
    Molecular Function: fucosyltransferase activity [IDA][ISS][NAS]
    Notch binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQWLKMKLRF VNLILLLISS TCAQLGGDPN GYLTYCPCMG RFGNQADHFL GSLAFAKALN  60
   61 RTLILPPWVE YRRGELRSRQ VPFNTYFEVE PLKEYHRVIT MADFMWHLAD DIWPESERVS 120
  121 FCYKERYSLQ QEKNDPDKPN CHAKDGNPFG PFWDTFHIDF VRSEFYAPLH FDVHHSNEAA 180
  181 KWQTKYPAES YPVLAFTGAP ASFPVQLENC KLQRYLQWSQ RYREASKDFI REQLPRGAFL 240
  241 GIHLRNGIDW VRACEHVKDS QHLFASPQCL GYKNERGALY PELCMPSKEA IIRQLKRTIK 300
  301 NVRQTQPDNE IKSVFVASDS NHMIGELNTA LSRMGISVHK LPEDDPYLDL AILGQSNHFI 360
  361 GNCISSYSAF EKRERDVHGF PSYFWGFPKE KDRKHTNVHE EL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..402] FFAS03 1.67 No description for 2hhcA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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