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Protein Overview: tum-PA

General Information:
Name(s) found: tum-PA / FBpp0086767 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene tumbleweed is referred to in FlyBase by the symbol Dmel\tum (CG13345, FBgn0086356). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9743648..9746222. It has the cytological map location 49C-50C6. Based on sequence similarity, it is predicted to have molecular function</span>: signal transducer activity; diacylglycerol binding; GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: Rho protein signal transduction; cell proliferation; maintenance of protein location in cell; dendrite morphogenesis; neuron development; negative regulation of Wnt receptor signaling pathway; mitotic spindle organization; cytokinesis. 29 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; peripheral nervous system; cuticle; external compound sense organ; adult segment; mushroom body; thoracic segment; adult mesothoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 625 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: cell proliferation [IGI]
    maintenance of protein location in cell [IMP]
    mitotic spindle organization [IMP]
    cytokinesis [IMP]
    negative regulation of Wnt receptor signaling pathway [IGI][IMP]
    Rho protein signal transduction [IGI]
    neuron development [IMP]
    dendrite morphogenesis [IMP]
    Molecular Function: GTPase activator activity [ISS]
    diacylglycerol binding [ISS]
    Rho GTPase activator activity [NAS]
    signal transducer activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALSALASFD DLRRCMQVLT DGTPEEEFLR FLRMFEQYHE KCAGYAAETA RIQNELDKSL  60
   61 TKMGDLEGKL FHARRIIDME IKARRQAEHE RDAMESKIMA VADLLRHERN LNNETRDKLA 120
  121 FLHTLPSSRK RKSLNAVRED KSYGDINSTG SLLSDLSITH SEDDFLDVRT SKSWREHRPS 180
  181 LPKNQIPSVG NKRSRLSTGL NGSMSGTTPT TGKSRRSSVG IGVEQHTVDV GQGAERFCAT 240
  241 TKVTIPQDGQ GVIRAESTIE SLPVIAGNER IGDGLSSTPR RSVLKEATAP PLTPVNAMAP 300
  301 HVVAESGTPL QHRPLMRNHT FSQKTFLRGD NCVQCQKRIR FGAVGLRCRD CPVRCHIDCR 360
  361 YLLTVSCVPQ TGTPTTKTMT GYVTDFAPSI APMIPALIVH CVNEIEARGL TEVGLYRLSS 420
  421 SEREYKALKE QFLRGKATPH LGNTDIYVLC CCVKDFLRSL TEPLIPTSQW KDFANAVQNP 480
  481 DTKTAQDMLV KSVKQLPQAN RDTLAFLILH FQRIAQCPVV LMPIDNISLI FGPTIVGYST 540
  541 PDPDQHAIYT EVFTQKQVMK ALLELPVSFW EQYIVIDPTR TPATVIKRVP SNKNDLLSLY 600
  601 ATPFKGGTIK KRKFYGTPPA SAHKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..289] PSI-BLAST 6.09691 Tropomyosin
    2 View Details [290..375] FFAS03 2.67 Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
    3 View Details [376..625] PSI-BLAST 41.045757 No description for 2ovjA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.71288992341677 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.43859890356027 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.42148330229896 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.78173505822139 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  1.76217210688028 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.73820712435638 bayes_pls_golite062009
  • protein binding
    		•  1.21002143294224 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.03969156339274 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.02645318226458 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.854618067843974 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.716569837044966 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.531562206762648 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.481861684281161 bayes_pls_golite062009
  • DNA binding
    		•  0.416562049130511 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.160536263083511 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle