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Protein Overview: EndoG-PA

General Information:
Name(s) found: EndoG-PA / FBpp0087120 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Endonuclease G is referred to in FlyBase by the symbol Dmel\EndoG (CG8862, FBgn0033690). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8064950..8066035. It has the cytological map location 48E4. There is experimental evidence that it has the molecular function</span>: endoribonuclease activity; endodeoxyribonuclease activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: DNA-dependent DNA replication. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 310 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISS]
    mitochondrial inner membrane [ISS]
    Biological Process: DNA-dependent DNA replication [ISS]
    Molecular Function: nucleic acid binding [IEA]
    metal ion binding [IEA]
    endodeoxyribonuclease activity [IDA][ISS]
    endoribonuclease activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPRVGGVL ALGATALGAF YLGTHVERER QHNGSTSGLP RLPGLPTFGT VSAASLIPAQ  60
   61 ENNVSLTATP SRIGQIMKYG FPGLDHVRSH SDYVLSYDRR NRVPHWVFEH LTAESVAKND 120
  121 AVDRSKCDFK QDESIHPFFR SQNTDYRRSG YDRGHMAAAG NHRLHQKHCD ETFYLSNMAP 180
  181 QVGQGFNRDA WNTLEAHVRR LTKTYSNVYV CTGPLYLPHK EDDGKSYVKY EVIGANTVAV 240
  241 PTHFYKVIVG ESADHKLHME SYVMPNQVIS NDTPISVFQV PPESVERSAG LLFFDQINRK 300
  301 QLTTINGKKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..310] PSI-BLAST 52.69897 Apo Crystal structure of Nuclease A from Anabaena sp.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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