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Protein Overview: FBpp0311591, Hdc...

General Information:
Name(s) found: FBpp0311591 [FlyBase]
FBpp0304256 [FlyBase]
Hdc-PA / FBpp0087422 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=2R:join(6128602..6128629,6129176..6129754,6129976..6130085,6130248..6130301,6130659..6131352,6131668..6131813,6131868..6132096,6132381..6133084); ID=FBpp0311591; name=Hdc-PD; parent=FBgn0005619,FBtr0345474; dbxref=FlyBase:FBpp0311591,FlyBase_Annotation_IDs:CG3454-PD; MD5=089b4a198205df3c1a79af51b46211e2; length=847; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=2R:join(6128602..6128629,6129176..6129754,6129976..6130085,6130248..6130301,6130659..6131352,6131668..6131813,6131868..6132096,6132381..6133084); ID=FBpp0304256; name=Hdc-PB; parent=FBgn0005619,FBtr0331923; dbxref=FlyBase:FBpp0304256,FlyBase_Annotation_IDs:CG3454-PB,REFSEQ:NP_001260855,GB_protein:AGB93388; MD5=089b4a198205df3c1a79af51b46211e2; length=847; release=r5.56; species=Dmel; [FlyBase]
  • The gene Histidine decarboxylase is referred to in FlyBase by the symbol Dmel\Hdc (CG3454, FBgn0005619). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6128374..6133588. It has the cytological map location 46F7. There is experimental evidence that it has the molecular function</span>: histidine decarboxylase activity. It is reported to be involved in the biological process</span>: compound eye photoreceptor development. 8 alleles are reported. The phenotypes of these alleles are annotated with: lobula plate; retina. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 847 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: compound eye photoreceptor development [NAS]
    cellular amino acid and derivative metabolic process [IEA]
    carboxylic acid metabolic process [IEA]
    Molecular Function: pyridoxal phosphate binding [IEA]
    histidine decarboxylase activity [IMP][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFKEYRQRG KEMVDYIADY LENIRERRVF PDVSPGYMRQ LLPESAPIEG EPWPKIFSDV  60
   61 ERIVMPGITH WQSPHMHAYF PALNSMPSLL GDMLADAINC LGFTWASSPA CTELEIIVMN 120
  121 WLGKMIGLPD AFLHLSSQSQ GGGVLQTTAS EATLVCLLAG RTRAIQRFHE RHPGYQDAEI 180
  181 NARLVAYCSD QAHSSVEKAA LIGLVRMRYI EADDDLAMRG KLLREAIEDD IKQGLVPFWV 240
  241 CATLGTTGSC SFDNLEEIGI VCAEHHLWLH VDAAYAGSAF ICPEFRTWLR GIERADSIAF 300
  301 NPSKWLMVHF DATALWVRDS TAVHRTFNVE PLYLQHENSG VAVDFMHWQI PLSRRFRALK 360
  361 VWFVLRSYGI KGLQRHIREG VRLAQKFEAL VLADHRFELP AKRHLGLVVF RIRGDNEITE 420
  421 KLLKRLNHRG NLHCIPSSLK GQYVIRFTIT STHTTLDDIV KDWMEIRQVA STVLEEMNIT 480
  481 ISNRVYLKET KEKNEAFGSS LLLSNSPLSP KVVNGSFAAI FDADEFLAKT YAGVRIAHQE 540
  541 SPSMRRRVRG ILMSGKQFSL DSHMDVVVQT TLDAGNGATR TSTTNSYGHT TSAAQANSER 600
  601 QASIQEDNEE SPEETELLSL CRTSNVPSPE HAHSLSTPSR SCSSSSHSLI HSLTQSSPRS 660
  661 SPVNQFRPIT LCAVPSQSQL SMPLAMPLPN RNVTVSVDSL LNPVTTCNVY HGKRFLEPLE 720
  721 NLAQTSASFS SSIFRLPTPI ATPTRESPED PDWPAKTFSQ LLLERYSSQS QSLGNNSSTE 780
  781 SSSLSGGATP TPTPMSSLDE LVTPLLLSFA SPSQPMLSAH GIGEGQREQG SDSDATVCST 840
  841 TSSMESL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..484] PSI-BLAST 118.0 DOPA decarboxylase
    2 View Details [485..624] deduced N/A No confident structure predictions are available.
    3 View Details [625..847] MSA 5.057997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  2.49533238079952 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  1.01853440922526 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • binding
    		•  0.252160165096264 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.130698724135981 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.11598778799668 bayes_pls_golite062009
  • aromatic-L-amino-acid decarboxylase activity
    		•  0.10589462882093 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle