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Protein Overview: CCS-PB

General Information:
Name(s) found: CCS-PB / FBpp0290166 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene CCS is referred to in FlyBase by the symbol Dmel\CCS (CG17753, FBgn0010531). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6008692..6010067. It has the cytological map location 46F1. There is experimental evidence that it has the molecular function</span>: superoxide dismutase copper chaperone activity. There is experimental evidence that it is involved in the biological process</span>: determination of adult lifespan; response to oxidative stress; protein stabilization. 12 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 264 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: response to oxidative stress [IMP]
    superoxide metabolic process [IEA]
    determination of adult lifespan [IMP]
    intracellular copper ion transport [ISS][NAS]
    oxidation reduction [IEA]
    protein stabilization [IDA]
    Molecular Function: superoxide dismutase copper chaperone activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSIKIEFAV QMRRGDESYA GALRSALDGV GQVEIDTQEG RVIIQTQRPW SEIQDKIEAT  60
   61 GVRAVLSGFG GQSAVALINT TGSVVDKTPI QGVVRFTTIT ADKKPGVVVD GVVDGLSPGL 120
  121 HGLHIHESGD TSAGCSSVGE HYNPRQSPHG SPAAGAEERH AGDLGNIRAD ENGRATFRFV 180
  181 DPVLEVWDII GRAVVLTANA DDLGRGGNDQ SLIDGNSGER IACGIIARSA GILENFKRIC 240
  241 ACDGVTLWDE RNKPLAGKER SQKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] PSI-BLAST 9.154902 The apo form of HMA domain of copper chaperone for superoxide dismutase
    2 View Details [71..264] PSI-BLAST 43.30103 Copper chaperone for superoxide dismutase, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein phosphatase 2B binding
    		•  13.5719110466797 bayes_pls_golite062009
  • superoxide dismutase activity
    		•  12.1093323949609 bayes_pls_golite062009
  • oxidoreductase activity, acting on superoxide radicals as acceptor
    		•  12.1093323949609 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  5.30724557593005 bayes_pls_golite062009
  • chaperone binding
    		•  5.11696266714142 bayes_pls_golite062009
  • copper ion binding
    		•  4.51765925795625 bayes_pls_golite062009
  • copper chaperone activity
    		•  3.53752588768671 bayes_pls_golite062009
  • protein phosphatase binding
    		•  3.26481550276071 bayes_pls_golite062009
  • phosphatase binding
    		•  3.1414149853516 bayes_pls_golite062009
  • metallochaperone activity
    		•  2.82622922333955 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  2.53311528765098 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.46331862428318 bayes_pls_golite062009
  • transition metal ion binding
    		•  2.451533032488 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.41954384727602 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.30916666149383 bayes_pls_golite062009
  • binding
    		•  2.28211284921339 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.0278666635337 bayes_pls_golite062009
  • protein binding
    		•  1.96660745768497 bayes_pls_golite062009
  • enzyme binding
    		•  1.82618630359051 bayes_pls_golite062009
  • metal ion binding
    		•  1.79413011653575 bayes_pls_golite062009
  • cation binding
    		•  1.79413011653575 bayes_pls_golite062009
  • ion binding
    		•  1.78699219376941 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.64083855886256 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.63756992236587 bayes_pls_golite062009
  • transporter activity
    		•  1.33910763967058 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.12504351752996 bayes_pls_golite062009
  • catalytic activity
    		•  1.09233965765942 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.704985452118462 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.618042428454534 bayes_pls_golite062009
  • zinc ion binding
    		•  0.25600715352161 bayes_pls_golite062009
  • antioxidant activity
    		•  0.240491838042064 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle