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Protein Overview: FBpp0300657, CG1...

General Information:
Name(s) found: FBpp0300657 [FlyBase]
CG12140-PA / FBpp0087472 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=2R:join(5798760..5798787,5798899..5799125,5799182..5799753,5799819..5800268,5800333..5800870); ID=FBpp0300657; name=Etf-QO-PB; parent=FBgn0033465,FBtr0308338; dbxref=FlyBase:FBpp0300657,FlyBase_Annotation_IDs:CG12140-PB,REFSEQ:NP_001246231,GB_protein:AFH07986; MD5=0252bcd06e1b031a90bf73e380a5c740; length=604; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG12140 (CG12140, FBgn0033465). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5798398..5800993. It has the cytological map location 46C4. Based on sequence similarity, it is predicted to have molecular function</span>: electron-transferring-flavoprotein dehydrogenase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: oxidative phosphorylation. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 604 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    mitochondrial inner membrane [ISS]
    Biological Process: oxidative phosphorylation [ISS]
    oxidation reduction [IEA]
    Molecular Function: electron-transferring-flavoprotein dehydrogenase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALMKMHRV RRLFSPALAR SISDVAKYPR ITTHYTLNPR EKDERWTEVD MERCVEEVDL  60
   61 VIVGGGPAGM SAAIRAKQLA AEKDQEIRVC VVEKAAEVGG HILSGAVIDP ISLNELIPDW 120
  121 QEQGAPLNTP VTKDTFSFLT GSGRISIPVF KGWPMDNHGN YVVRLGHLVK WLGDQAEALG 180
  181 VEIYPGCAAS EVLFHEDGSV KGIATNDVGI AKSGAPKDTF ARGMELHAKT TIFAEGCRGH 240
  241 LTKQIMQKFG LNEGSEPQAY GIGLKEVWEI APEKHQPGLV EHTIGWPLDR FTYGGSFLYH 300
  301 LNEPTPTIAV GFVVGLNYKN PWLSPFQEFQ RFKTHPKVRD VFEGATRIAY GARAINEGGF 360
  361 QSLPQKLSFP GGCLVGCSAG FLNVPRIKGS HYAMKSGMLA AESAFEAINA DAQSTAGVEP 420
  421 TGYAEKIKDS FVWKDLYSVR NVHPSFHNPL GLYGGLVLSG FSIFMGGREP WTLKHGPQDH 480
  481 ESLKPASSCP PIVYPKPDGK ISFDLLSSVA LTGTNHEGDQ PAHLTLKDDR IPVDHNLALY 540
  541 EGPEQRFCPA GVYEYVPNEE GGNMKLQINA QNCIHCKTCD IKDPKQNINW VVPEGGGGPA 600
  601 YNGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..604] PSI-BLAST 147.0 No description for 2gmhA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  6.5929955386305 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  6.45562261241375 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  6.34963309803617 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  5.69483449389334 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  3.91001933271643 bayes_pls_golite062009
  • electron carrier activity
    		•  3.21957528314564 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.11137503143637 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.10483430063263 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.04960158864768 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  3.0400550620086 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.87261684242536 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.79579164562277 bayes_pls_golite062009
  • electron-transferring-flavoprotein dehydrogenase activity
    		•  2.1276770745496 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.45104542724719 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  1.35744482443829 bayes_pls_golite062009
  • transporter activity
    		•  1.2818063852101 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
    		•  1.08975609376408 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07293152484928 bayes_pls_golite062009
  • binding
    		•  0.850925220183928 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.69501605197281 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.556967966402473 bayes_pls_golite062009
  • catalytic activity
    		•  0.488483980994331 bayes_pls_golite062009
  • metal cluster binding
    		•  0.484911132627709 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  0.484911132627709 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.31459693204333 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.301257942260531 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.162130833238942 bayes_pls_golite062009
  • protein binding
    		•  0.122045589752402 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.10059033442163 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.0827182678048914 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0724852054074128 bayes_pls_golite062009
  • DNA binding
    		•  0.022476246602636 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.31

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle