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Protein Overview: Wnt2-PA

General Information:
Name(s) found: Wnt2-PA / FBpp0087596 [FlyBase]
Description(s) found:
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  • gi|7303888|gb|AAF58933.1| Wnt oncogene analog 2 [Drosophila melanogaster] [NCBI NR]
  • gi|34395990|sp|P28465.2|WNT2_DROME RecName: Full=Protein Wnt-2; AltName: Full=dWnt-2; Flags: Precursor [NCBI NR]
  • gi|17136628|ref|NP_476810.1| Wnt oncogene analog 2 [Drosophila melanogaster] [NCBI NR]
  • Protein Wnt-2 OS=Drosophila melanogaster GN=Wnt2 PE=2 SV=2 [Swiss-Prot]
  • The gene Wnt oncogene analog 2 is referred to in FlyBase by the symbol Dmel\Wnt2 (CG1916, FBgn0004360). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5381674..5390695. It has the cytological map location 45E1. Based on sequence similarity, it is predicted to have molecular function</span>: signal transducer activity; receptor binding. There is experimental evidence that it is involved in the biological process</span>: muscle organ development; axon extension; open tracheal system development. 19 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; adult segment; adult mesothoracic segment; adult somatic muscle; gonadal sheath; embryonic/larval tracheal system; portion of tissue; adult visceral muscle; embryonic dorsal trunk; thoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG1916-PA translation from_gene[CG1916 Wnt2 FBgn0004360] seq_release:3 mol_weight=39763 cds_boundaries:(2R:4,555,830..4,563,668[+]) aa_length:352 transcript_info:[CG1916-RA seq_release:3] gene_info:[gene symbol:Wnt2 FBgn0004360 gene_boundaries:(2R:4,5 [hmr_yeast5_DM3-1_pombe.fasta]
  • (P28465) Wnt-2 protein precursor (dWnt-2) [DrosMelano7227.FASTAC.txt]
  • (AE003833) Wnt2 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1916-PA [Drosophila melanogaster]gi|17136628|ref|NP_476810.1| CG1916-PA [Drosophila melanogaster]gi|34395990|sp|P28465|WNT2_DROME Wnt-2 protein precursor (dWnt-2) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(5382703..5382758,5388876..5389093,5389478..5389761,5389827..5390014,5390232..5390544); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933. [fly-100309-contam.fasta]
  • Protein Wnt-2 precursor (dWnt-2) [nr-271106-contam.fasta]
  • CG1916-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Wnt oncogene analog 2 CG1916-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(5382703..5382758,5388876..5389093,5389478..5389761,5389827..5390014,5390232..5390544); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(5382703..5382758,5388876..5389093,5389478..5389761,5389827..5390014,5390232..5390544); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:join(5382703..5382758,5388876..5389093,5389478..5389761,5389827..5390014,5390232..5390544); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933,FlyMine:FBpp0087596,modMine:FBpp0087596; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(9495198..9495253,9501371..9501588,9501973..9502256,9502322..9502509,9502727..9503039); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933,FlyMine:FBpp0087596,modMine:FBpp0087596; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(9495198..9495253,9501371..9501588,9501973..9502256,9502322..9502509,9502727..9503039); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933,FlyMine:FBpp0087596,modMine:FBpp0087596; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087596 type=protein; loc=2R:join(9495198..9495253,9501371..9501588,9501973..9502256,9502322..9502509,9502727..9503039); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933,FlyMine:FBpp0087596,modMine:FBpp0087596; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(9495198..9495253,9501371..9501588,9501973..9502256,9502322..9502509,9502727..9503039); ID=FBpp0087596; name=Wnt2-PA; parent=FBgn0004360,FBtr0088512; dbxref=FlyBase:FBpp0087596,FlyBase_Annotation_IDs:CG1916-PA,GB_protein:AAF58933.1,REFSEQ:NP_476810,GB_protein:AAF58933,UniProt/Swiss-Prot:P28465,FlyMine:FBpp0087596,modMine:FBpp0087596; MD5=d884cee4053fd91f06cbd4ba6a69849b; length=352; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 352 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IEA][NAS]
    Biological Process: muscle organ development [IMP]
    axon extension [IMP]
    Wnt receptor signaling pathway, calcium modulating pathway [ISS]
    Wnt receptor signaling pathway [NAS]
    open tracheal system development [IGI]
    Molecular Function: signal transducer activity [ISS]
    receptor binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKIHNKLLI YILWIMEIRL VSSFTSVMLC GRIPGLTPGQ RNMCREMPDA LIALGEGHQL  60
   61 GAQECQHQFR GHRWNCSEVW QRNVFAHVIP TASREAAYTY AIASAGAAYA VTAACARGNI 120
  121 STCGCDVRHK ATPTGGGTPD EPWKWGGCSA DVDFGMRYAR RFMDARELER DSRTLMNLHN 180
  181 NRAGRTLVKK MLRTDCKCHG VSGSCVMKTC WKSLPPFRLV GDRLMLKYQK AKTVQAVKGK 240
  241 RGLRLVLSRK KHAGTARAQK PVLDWPKRME LIYLEASPNY CERSLQTGSQ GTSGRTCQRT 300
  301 GHGPQSCDLL CCGRGHNTQH IRRTTQCRCQ FRWCCEVKCD ECDESYEEFT CK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..200] MSA 8.192958 View MSA. No confident structure predictions are available.
    2 View Details [201..352] MSA 42.230982 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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