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Protein Overview: Rme-8-PA

General Information:
Name(s) found: Rme-8-PA / FBpp0087699 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Receptor mediated endocytosis 8 is referred to in FlyBase by the symbol Dmel\Rme-8 (CG8014, FBgn0015477). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5055261..5064685. It has the cytological map location 45B1-45B2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: heat shock protein binding. There is experimental evidence that it is involved in the biological process</span>: border follicle cell migration; receptor-mediated endocytosis. 25 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2408 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: border follicle cell migration [IMP]
    endocytosis [NAS]
    receptor-mediated endocytosis [IMP]
    Molecular Function: heat shock protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPPKENVDL ECFLVTKHSW KGRYKRILSI GTAGISTYNP DKLDLTNRWS YSDIVAAAPS  60
   61 KTTNIPHDFV ITIKKDKKLD TIKLSSEYRN DILSSILKYY KEFADKPKNA QRFSAYKYHW 120
  121 SGISLPTVLE VTPCSLDQLD PTTNDVLASY MYKDIEGIIA GISDYEGGIV MAYGGFSRLH 180
  181 LFKALNHHEI VQNIAQRSAQ FLGIETKILK SQITLEQFER QRFGKFSGDQ FQTSSTEFSV 240
  241 HKITPRHPDP VKRILCLTEV TLLERDPQTY SVCTLRPLTD VFALVRDKDN LQRFSIEYKN 300
  301 GIVRNYSTND RDSLLATVLD AVRSSGNQDV HVRIGNTPRG KRYVPLNSSV DEETEANLMR 360
  361 LVINNFQNPS KRYEILERFN ANVPHSGLNY SVTQDSLFAE NKDKLILSAL QALAQKELDS 420
  421 PTAQLSNLEL EAIFHALTRL LASKVGYAAF TNLPGFREII GTKVVAALRR KDLAVTYSAI 480
  481 DMINSLMHSV NSDHDLKQEQ LNKSSILSSK SFLETLLNMW TTHVSHGSGA LVLSAMLDFM 540
  541 TFALCVPYSE TTDGKQFDTL LELVADRGRY LYKLFQHPSL AIVKGAGLVL RAIIEEGELQ 600
  601 VAQQMQALAL DEAALCRHLL VALYTPSNDP TQTTQRQLSR HLIGLWLTDS EEAMELFKRI 660
  661 FPAGLLTFLE SEETVPESDV EEDKLNFRDN LKFAIQHSNK TRKNVIEKHL QGIKHWGMNL 720
  721 IEKQDGAAQA LKNRPVVLRN RRQKKKTSDV VVNLPFFFYS FAKDHSLPNL IWNHKTREEL 780
  781 RMCLENELRQ FLNDRDLAGQ MIVAWNYQEF EVAYQCLADE IKIGDYYIRL ILEKDDWPQN 840
  841 LVKDPIELFN ALYRRVLCRQ RVNDDQMTVF SLQALAKVYR RYHAEIGKFN DMSYILQLSD 900
  901 RCLSPSMRDA LINLISCLVL EKSNSRALID HVQCLVDLIT LAHLHKGRAQ LNTKTNVIEA 960
  961 GPNMGTYEEK DWYYNIEKDG QKPERQGPIT YSELKELWQK GLITPKTRCW AIGMDGWRSL1020
 1021 QQIPQLKWCL IAKGTPLYDE TELSSKILDI LIKCTSFFPS RTQNGVAVLI PGPKLSRKLS1080
 1081 EFICLPHVVQ VCLTHDPGLL ERVATLLYQI MEDNPEMPKV YLTGVFYFML MYTGSNILPI1140
 1141 TRFLKMTHMK QGFRSEETSQ SGIMHRSILG QLLPEAMVCF LENYSAEKFA EIFLGEFDTP1200
 1201 EVIWSSEMRR LLIEKIAAHI ADFTPRLRGH TMARYPYLAI PVISYPQLEN ELFCHIYYLR1260
 1261 HLCDTQKFPN WPISDPVQLL KHTLDAWRKE VEKKPPQMTI QQAYQDLGID LTKTPKPDES1320
 1321 MIRKSYYKLA QMYHPDKNPN GREIFEKVNQ AYEFLCSRNV WSSGGPDPNN IVLILRTQSI1380
 1381 LFERYPDVLR PYKYAGYPQL IKTIRLETRD DELFSKEAQL LTAASELCYH TVHCSALNAE1440
 1441 ELRREEGIEA LLEAYTRCVS ILGVDSKPDS LHYQVISNVT RCFEVACNFE KCKQKIIQLP1500
 1501 QLLSDVCRVV YFKHTLSVSL VTSLAANNYD LQCQLSRNGV LWSLLLFIFE YDYTLDESGV1560
 1561 DVSDKSNQQQ LANNLAKMAV LGCIALAGYS MELRQKPVTG SETNSPAAKA PPVIKPKPSV1620
 1621 SAASSSTYTQ NAHNPLQSKQ LAITSGKEKE SDTSSGSSDT ASSTPTESEQ QQQLTKTRTS1680
 1681 AIQQKYIVTG EAKNSLIKQV LDRLLTRYIS NQLATVRDSD VLKLLTANTR NPYLIWDNGT1740
 1741 RAQLKDFLEQ QRTASAKETH EDIAQVSELV SSFEFDAHKD ELQIGGIFIR IYNDMPTHPI1800
 1801 AQPKLFIMDL LEYLKHAYQF LQYKKNPAST AAPVNATPKM GNDGILTPTL APNHPQLQQA1860
 1861 STGKSGTTFD EVLTAYNRSK SRKKLETDAL TEQQLALQQS KYDFSSDGKI ELHITMVLKA1920
 1921 LIAVIKANAE VEIQCIGNFD MIFGFLASNI FPDNSTVKAV ALEVVSLVSR NKECVSEVAA1980
 1981 CEILGNYLVA LKDPELRASQ VKVLETLSGL MNVQEMIKEA QAKGATIYLL DMFCNSRNPQ2040
 2041 IREMCAGILA KMTADRLSGP KVRITVSKFL PALFIDAMVE SPATSVQLFE SIHEHPELIW2100
 2101 NDTTRSNVCD AVADTCQRFY QLQKANSRHV WKDPEILKDI VSNEIVVAGV YLRLFVSNPA2160
 2161 WTLRKPKQFL SDLLDFVVEQ IGKSSSEQDV LDLSTTALVE LLRSQPNLAD DIPVLGHIPK2220
 2221 LFNLLSVQPK NTLSVLHQLS LSEFCVSAIS QTECVAPLKK CMEHNRDCIE KACEALSRLF2280
 2281 KHQHDSLISQ SLEVGLIPFL LGLLDSRLEF VDNPSAVKAQ IVAALKGMTH NLNYGDRVTQ2340
 2341 ILLKHPVWAE FKDQRHDLFI ADTTIRGYLT GVNPTAGYLT AGPAQSVEVL TSPPPIDRDD2400
 2401 PSARPPID

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] deduced N/A No confident structure predictions are available.
    2 View Details [107..248] MSA 1.013945 View MSA. No confident structure predictions are available.
    3 View Details [249..327] deduced N/A No confident structure predictions are available.
    4 View Details [328..488] MSA 1.01394 View MSA. No confident structure predictions are available.
    5 View Details [489..630] deduced N/A No confident structure predictions are available.
    6 View Details [631..861] MSA 1.019952 View MSA. No confident structure predictions are available.
    7 View Details [862..955] deduced N/A No confident structure predictions are available.
    8 View Details [956..1037] MSA 12.031996 View MSA. No confident structure predictions are available.
    9 View Details [1038..1294] deduced N/A No confident structure predictions are available.
    10 View Details [1295..1405] PSI-BLAST 22.0 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
    11 View Details [1406..1621] PSI-BLAST 19.0 The crystal structure of Hsp40 Ydj1
    12 View Details [1622..1774] deduced N/A No confident structure predictions are available.
    13 View Details [1775..1828] deduced N/A No confident structure predictions are available.
    14 View Details [1829..2055] deduced N/A No confident structure predictions are available.
    15 View Details [2056..2132] deduced N/A No confident structure predictions are available.
    16 View Details [2133..2294] MSA 1.013962 View MSA. No confident structure predictions are available.
    17 View Details [2295..2408] MSA 2.014978 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10
    Term Confidence Notes
  • binding
    		•  1.58214482002828 bayes_pls_golite062009
  • protein binding
    		•  1.37672975699838 bayes_pls_golite062009
    11
    Term Confidence Notes
  • binding
    		•  1.68064826625864 bayes_pls_golite062009
  • protein binding
    		•  1.3466202387299 bayes_pls_golite062009
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.
    15 No functions predicted.
    16 No functions predicted.
    17 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

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