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Protein Overview: Hey-PA

General Information:
Name(s) found: Hey-PA / FBpp0087945 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Hairy/E(spl)-related with YRPW motif is referred to in FlyBase by the symbol Dmel\Hey (CG11194, FBgn0027788). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3882941..3886078. It has the cytological map location 44A2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; DNA binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: negative regulation of Notch signaling pathway. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA]
    negative regulation of Notch signaling pathway [ISS]
    Molecular Function: DNA binding [ISS]
    transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHNMHVNAP SLHHWGYAAG PGVVMPGATA TTPQSHWVPP PQSHHSAHSN HSHGHSQGHS  60
   61 HGIGSLKRTL SESDCDDLYS EESSKEQISP SEPGSCQLMS RKKRRGVIEK KRRDRINSSL 120
  121 TELKRLVPSA YEKQGSAKLE KAEILQLTVE HLKSLQSKTL DSLSYDPQRV AMDYHIIGFR 180
  181 ECAAEVARYL VTIEGMDIQD PLRLRLMSHL QYFVQQRELS AKSCASPGGW SPAAPSSSGY 240
  241 QPNCAAAPYQ SYAAPANPGA YVSSYPTLSA SPSQQAQQLG GRTSVSRTSG SAVTESLPSH 300
  301 DLHSDSSSQQ QQQQQQQQQQ QQQHQQQQHQ QQQQRTQTTP QPTQQQHYTH DHSAVHSEQQ 360
  361 VPTYIELTNS NRPAAIGSDS LSYSAAPQYP VSGLPGQDYN NSSVLQYATP NGAKPYRPWG 420
  421 AEMAY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] deduced N/A No confident structure predictions are available.
    2 View Details [82..163] PSI-BLAST 11.221849 Usf B/HLH domain
    3 View Details [164..204] PSI-BLAST 5.0 No description for 2db7A was found.
    4 View Details [205..425] FFAS03 1.15 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.12507195426228 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.43204604575196 bayes_pls_golite062009
  • DNA binding
    		•  0.40884226851256 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.31759335140578 bayes_pls_golite062009
  • transcription factor activity
    		•  0.09721565916723 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  0.533405820900955 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle