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Protein Overview: drosha-PA

General Information:
Name(s) found: drosha-PA / FBpp0087926 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene drosha is referred to in FlyBase by the symbol Dmel\drosha (CG8730, FBgn0026722). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3819931..3824360. It has the cytological map location 43F2-43F3. Based on sequence similarity, it is predicted to have molecular function</span>: double-stranded RNA binding; ribonuclease III activity. There is experimental evidence that it is involved in the biological process</span>: primary microRNA processing. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1327 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: primary microRNA processing [IMP][ISS]
    Molecular Function: ribonuclease III activity [ISS][NAS]
    double-stranded RNA binding [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQPPLPPPP VQPAPPPPPP PPEEDLSPPG VGVPSHNYSS NESHSQSSKS LDYVYPETPA  60
   61 PYASSVPSYD PYQQPPAYGY EGYAYNEQAQ KYGGQESHYQ YQYPASGSSF LYESYKYPDR 120
  121 YPAYSSNYRP PSERQRYTSN SSSQGYHHYP GYSSGRRYEQ RHDQEHRQIQ DSRYAHEPRH 180
  181 GHYAHRQAKG SQHGYYGSAA RNQVSDDYSP RGHHERERNE TLEKTRAKPK VETERDRLLR 240
  241 QWCSNFCEKP EDYVKKMNAL SEADAPVESW VRSSPAELYY ERTKSENEVR GRARLQKLCT 300
  301 LFDEELLQRA KRVREKLPVY VPPPRKARRR VCKHKHKSEA CSSSSSSDDD SDEDAFKIEQ 360
  361 DCCMEELSRK VQHPQRVHAD LWHNDAGEMN DGPLCRCSAK SRRIGIRHGI YPGETGYKLC 420
  421 DPNSNNAGKL FHYRISISPP TNFLTKTPTI IKHDEHEFLF EGFSLLSHVR LSDLPVCKVI 480
  481 RFNIEYTIEY EEEKMPENFT IHELDIFFKY LFHELLELVD FNLMPNLPSG NVEESCPAFH 540
  541 FFPRFVRDLP DNGKEVLAMV EVLRYLLDNS AQLVERQQLL HLNQISQSEW QNYVDFIKGM 600
  601 LVTKPGYKPC SLRVDQLDRN NSDLPECVDR ETGISHPAIV HFGICHPQLS YAGNPEYQKA 660
  661 WREYVKYRHL MANMSKPSFK DKRKLEEKEQ RLQEMRTQGR MKRNITVAIS SEGFYRTGIM 720
  721 CDVVQHAMLI PVLTGHLRFH KSLDLLEESI GYRFKNRYLL QLALTHPSYK ENYGTNPDHA 780
  781 RNSLTNCGIR QPEYGDRKIH YMNTRKRGIN TLVSIMSRFG KEHETVSNIT HNERLEFLGD 840
  841 AVVEFLSSIH LFFMFPELEE GGLATYRAAI VQNQHLALLA KKLQLEEFML YAHGSDLCHE 900
  901 LELRHAMANC FEALMGALLL DGGIKVADEV FTDALFRQDE KLLSIWKNLP EHPLQEQEPL 960
  961 GDRSCIDSYR VLKELTKFED SIGIKFKHIR LLARAFTDRS IGFTHLTLGS NQRLEFLGDT1020
 1021 VLQLICSEYL YRHFPEHHEG HLSLLRSSLV NNRTQAVVCD DLGMPKYAVY ANPKADLKTK1080
 1081 DRADLLEAFL GALYVDKGLL YCEQFCHVCL FPRLQLFIMN QDWNDPKSKL QQCCLTLRTM1140
 1141 DGGEPDIPYY KVVEASGPTN TRVYKVAVYF RSKRLATSSG SSIQQAEMNA AKQALENSRD1200
 1201 LFPQLDHQKR VIAKSIKKQT GNELDNDSDR QHQEEKIKRP KYATPLQDES HLPKQYRMHE1260
 1261 NISSDELPED EDFESTAPKS PTMPLRSNRS GSSSSSSSSD SDGSTSSPKC KRRLKKCSSV1320
 1321 SSKSSLG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..441] PSI-BLAST 5.69897 No description for 1y0fB was found.
    2 View Details [442..800] FFAS03 1.38 Crystal Structure of Dicer from Giardia intestinalis
    3 View Details [801..968] PSI-BLAST 33.0 RNase III endonuclease catalytic domain
    4 View Details [969..1200] PSI-BLAST 64.30103 RNase III endonuclease catalytic domain; RNase III, C-terminal domain
    5 View Details [1201..1327] PSI-BLAST 5.0 dsRNA-dependent protein kinase pkr


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle