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Protein Overview: CG2137-PA

General Information:
Name(s) found: CG2137-PA / FBpp0087981 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG2137 (CG2137, FBgn0033190). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3423424..3425802. It has the cytological map location 43D3. Based on sequence similarity, it is predicted to have molecular function</span>: glycerol-3-phosphate dehydrogenase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: glycerol metabolic process. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 713 amino acids

    Gene Ontology:
    Cellular Component: glycerol-3-phosphate dehydrogenase complex [IEA]
    mitochondrion [ISS]
    Biological Process: glycerol metabolic process [ISS]
    glycerol-3-phosphate metabolic process [IEA]
    oxidation reduction [IEA]
    Molecular Function: calcium ion binding [IEA]
    glycerol-3-phosphate dehydrogenase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKIIQMAVM LGSSKLGHGA FGFDERQADS TPVPQMKREL PTRKMCLEAF KRTHYDILII  60
   61 GGGAVGSGCA LDAATRGLKT ALVEANDFGS GTSSKSSKLL HGGLRDLEQA ISRLDVAAFR 120
  121 RVRCSLQERS HIGKLAPHLS QPVPILLPVH HWWQAPLYYM KLKIYHLMAP KATRSFQYLS 180
  181 ADDALEVFPM LRRQELFGAF VFYEGQHDDA RMCLSVALTA ARYGADICNH MKVSRLIKNK 240
  241 DGNVAGAEAV DQLTGKKYSI RAKVVVNATG HMSDSLRQME DSEAKPLCTR SWSSIIVMPR 300
  301 FYCPEEVGVF DPHTPSGRSI FFLPWQGHTL VGSSDEPLNL PEQDTQPTET DVQSLLDCVK 360
  361 HFVTPNFDVR RCDVLAVWGG YKPLPVQSDT LHHTRFKNHV IQLGPRNMLS IVGGTWSSFR 420
  421 VLAEKTVNAA IRYGDLSPLR KESVTAESCK LDGASGWSPK MFIRLVQDFG MERDVAEHLS 480
  481 NTYGSNAFKV AVSADSSGKA WPIVGKRLHS EFPYIEAEVK QGVRDFACTL EDMVARRLRV 540
  541 AFLNVQVAEE ILPQVANIMA KELNWSRDQI KKQIRQTRTF LNSQMGQLTK ESASQMSIPI 600
  601 KMSVRQVRKF AGQFRQMDDN NTGYVSIADC CKAMKTMGVK EVPVDLMHDV LRDIDVHAQG 660
  661 KVNLYEFLLL MSAIVQGNTE YLRYARLYLD HKRQMQGSNF PTVMQMERAG GGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..608] PSI-BLAST 37.69897 Crystal structure of dimethylglycine oxidase of Arthrobacter globiformis in complex with acetate
    2 View Details [609..713] PSI-BLAST 34.045757 CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on NADH or NADPH
    		•  5.26950448055146 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.3417445147889 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  2.25002926602325 bayes_pls_golite062009
  • electron-transferring-flavoprotein dehydrogenase activity
    		•  1.55451764082771 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.45104542724719 bayes_pls_golite062009
  • transporter activity
    		•  1.29839290134235 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.18990628739838 bayes_pls_golite062009
  • antioxidant activity
    		•  1.12347155061135 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
    		•  1.08975609376408 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07862908893913 bayes_pls_golite062009
  • catalytic activity
    		•  1.03127962968326 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  0.955909900559292 bayes_pls_golite062009
  • binding
    		•  0.850689563354756 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.811783414198063 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  0.69501605197281 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.573803337547311 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.55964362614766 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  0.494423552127166 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  0.442625746935807 bayes_pls_golite062009
  • protein binding
    		•  0.370064403093958 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.262741975112034 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.224438371728402 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.164825358655637 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.162130833238942 bayes_pls_golite062009
  • amine oxidase activity
    		•  0.0576694782267841 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.057221373695437 bayes_pls_golite062009
  • DNA binding
    		•  0.022476246602636 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.30946149202257 bayes_pls_golite062009
  • protein binding
    		•  1.18539140568889 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • calcium ion binding
    		•  1.03474411638676 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • ion binding
    		•  0.882500417315612 bayes_pls_golite062009
  • cation binding
    		•  0.87665890173512 bayes_pls_golite062009
  • metal ion binding
    		•  0.87665890173512 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.2350628837209 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • motor activity
    		•  0.0886596083402598 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0215587845132821 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0215587845132821 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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