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Protein Overview: didum-PC

General Information:
Name(s) found: didum-PC / FBpp0088684 [FlyBase]
Description(s) found:
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  • gi|24586270|ref|NP_724569.1| dilute class unconventional myosin, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|21627786|gb|AAM68902.1| dilute class unconventional myosin, isoform C [Drosophila melanogaster] [NCBI NR]
  • The gene dilute class unconventional myosin is referred to in FlyBase by the symbol Dmel\didum (CG2146, FBgn0261397). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3387660..3396130. It has the cytological map location 43C7-43D1. There is experimental evidence that it has the molecular function</span>: actin binding; actin-dependent ATPase activity; ATP binding; myosin light chain binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of pole plasm oskar mRNA localization; sperm individualization; rhabdomere development; determination of anterior/posterior axis, embryo. 19 alleles are reported. The phenotypes of these alleles are annotated with: spermatid cyst; spermatozoon. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG2146-PC translation from_gene[CG2146 didum FBgn0015933] seq_release:3 mol_weight=208248 cds_boundaries:(2R:2,561,380..2,568,756[+]) aa_length:1800 transcript_info:[CG2146-RC seq_release:3] gene_info:[gene symbol:didum FBgn0015933 gene_boundaries:(2R [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8MKM1) CG2146-PC [DrosMelano7227.FASTAC.txt]
  • CG2146-PC, isoform C [Drosophila melanogaster]gi|24586270|ref|NP_724569.1| CG2146-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(3387984..3388013,3388416..3389229,3389295..3389533,3389607..3390095,3390149..3390242,3390307..3390533,3390677..3390700,3391154..3391267,3391334..3392220,3392280..3392806,3392869..3393004,3393154..3393251,3393344..3393524,3393582. [fly-100309-contam.fasta]
  • CG2146-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • dilute class unconventional myosin CG2146-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(3387984..3388013,3388416..3389229,3389295..3389533,3389607..3390095,3390149..3390242,3390307..3390533,3390677..3390700,3391154..3391267,3391334..3392220,3392280..3392806,3392869..3393004,3393154..3393251,3393344..3393524,3393582..3394094,3394160..3394291,3394354..3394882,3394941..3395165,3395220..3395363); ID=FBpp0088684; name=didum-PC; parent=FBgn0015933,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(3387984..3388013,3388416..3389229,3389295..3389533,3389607..3390095,3390149..3390242,3390307..3390533,3390677..3390700,3391154..3391267,3391334..3392220,3392280..3392806,3392869..3393004,3393154..3393251,3393344..3393524,3393582..3394094,3394160..3394291,3394354..3394882,3394941..3395165,3395220..3395363); ID=FBpp0088684; name=didum-PC; parent=FBgn0015933,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Dilute class unconventional myosin, isoform C OS=Drosophila melanogaster GN=didum PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(3387984..3388013,3388416..3389229,3389295..3389533,3389607..3390095,3390149..3390242,3390307..3390533,3390677..3390700,3391154..3391267,3391334..3392220,3392280..3392806,3392869..3393004,3393154..3393251,3393344..3393524,3393582..3394094,3394160..3394291,3394354..3394882,3394941..3395165,3395220..3395363); ID=FBpp0088684; name=didum-PC; parent=FBgn0261397,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902,FlyMine:FBpp0088684,modMine:FBpp0088684; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(7500479..7500508,7500911..7501724,7501790..7502028,7502102..7502590,7502644..7502737,7502802..7503028,7503172..7503195,7503649..7503762,7503829..7504715,7504775..7505301,7505364..7505499,7505649..7505746,7505839..7506019,7506077..7506589,7506655..7506786,7506849..7507377,7507436..7507660,7507715..7507858); ID=FBpp0088684; name=didum-PC; parent=FBgn0261397,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902,FlyMine:FBpp0088684,modMine:FBpp0088684; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(7500479..7500508,7500911..7501724,7501790..7502028,7502102..7502590,7502644..7502737,7502802..7503028,7503172..7503195,7503649..7503762,7503829..7504715,7504775..7505301,7505364..7505499,7505649..7505746,7505839..7506019,7506077..7506589,7506655..7506786,7506849..7507377,7507436..7507660,7507715..7507858); ID=FBpp0088684; name=didum-PC; parent=FBgn0261397,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902,FlyMine:FBpp0088684,modMine:FBpp0088684; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Dilute class unconventional myosin, isoform C OS=Drosophila melanogaster GN=didum PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0088684 type=protein; loc=2R:join(7500479..7500508,7500911..7501724,7501790..7502028,7502102..7502590,7502644..7502737,7502802..7503028,7503172..7503195,7503649..7503762,7503829..7504715,7504775..7505301,7505364..7505499,7505649..7505746,7505839..7506019,7506077..7506589,7506655..7506786,7506849..7507377,7507436..7507660,7507715..7507858); ID=FBpp0088684; name=didum-PC; parent=FBgn0261397,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902,FlyMine:FBpp0088684,modMine:FBpp0088684; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(7500479..7500508,7500911..7501724,7501790..7502028,7502102..7502590,7502644..7502737,7502802..7503028,7503172..7503195,7503649..7503762,7503829..7504715,7504775..7505301,7505364..7505499,7505649..7505746,7505839..7506019,7506077..7506589,7506655..7506786,7506849..7507377,7507436..7507660,7507715..7507858); ID=FBpp0088684; name=didum-PC; parent=FBgn0261397,FBtr0089743; dbxref=FlyBase:FBpp0088684,FlyBase_Annotation_IDs:CG2146-PC,GB_protein:AAM68902.1,REFSEQ:NP_724569,GB_protein:AAM68902,UniProt/TrEMBL:A1Z6Z8,FlyMine:FBpp0088684,modMine:FBpp0088684; MD5=333a93ad683cbea6e2f9f9f689e0be56; length=1800; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1800 amino acids

    Gene Ontology:
    Cellular Component: myosin complex [ISS]
    Biological Process: sperm individualization [IMP]
    anterior/posterior axis specification, embryo [IMP]
    [NOT]oogenesis [IMP]
    rhabdomere development [IMP]
    positive regulation of pole plasm oskar mRNA localization [IMP]
    Molecular Function: actin filament binding [IEA]
    ATP binding [IDA][ISS]
    actin-dependent ATPase activity [IDA]
    calmodulin binding [ISS]
    actin binding [IDA][ISS]
    myosin light chain binding [IPI]
    motor activity [ISS]
    ATPase activity, coupled [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEMLYAQ GAKIWVPHAD LVWESATLEE SYRKGAGFLK ICTDSGKLKE VKLKADGSDL  60
   61 PPLRNPAILV GQNDLTTLSY LHEPGVLHNL RVRFCERQII YTYCGIILVA INPYAEMPLY 120
  121 GPSIIRAYRG HAMGDLEPHI FALAEEAYTK LERENCNLSI IVSGESGAGK TVSAKYAMRY 180
  181 FAAVGGSESE TQVERKVLAS SPIMEAFGNA KTTRNDNSSR FGKFTKLLFR NQMGVMFLQG 240
  241 ATMHTYLLEK SRVVYQAQGE RNYHIFYQLC AARSKYPELV LDHQDKFQFL NMGGAPEIER 300
  301 VSDAEQFNET VQAMTVLGFS IQQIADIVKI LAGILHLGNI QVSKKFNEGS EEEDSDSCDI 360
  361 FHNDIHLQIT ADLLRVSADD LRRWLLMRKI ESVNEYVLIP NSIEAAQAAR DALAKHIYAK 420
  421 LFQYIVGVLN KSLNNGSKQC SFIGVLDIYG FETFEVNSFE QFCINYANEK LQQQFNQHVF 480
  481 KLEQEEYLKE GITWTMIDFY DNQPCIDLIE SRLGVLDLLD EECRMPKGSD ESWAGKLIGK 540
  541 CNKFPHFEKP RFGTTSFFIK HFSDTVEYDV NGFLEKNRDT VSKELTQVLS ESNMSLAKQV 600
  601 MTLEEIDTLC VDSAKSSTLG GRVVISAGRK QQGNDTRRRV VPSKQHRKTV GSQFQESLAS 660
  661 LISTLHATTP HYVRCIKPND DKVAFKWETA KIIQQLRACG VLETVRISAA GFPSRWLYPD 720
  721 FYMRYQLLVY RSKLDKNDMK LSCRNIVMKW IQDEDKYRFG NTQIFFRAGQ VAFLEQVRAN 780
  781 LRKKYITIVQ SVVRRFVYRR QFLRIQKVIN GIQKHARGYL ARERTQKMRE ARAGLILSKY 840
  841 ARGWLCRRRY LRLRHSISGI QTYARGMLAR NKFHAMRDHY RAVQIQRFVR GALARRAYQK 900
  901 RRRNIIICQA AIRRFLARRK FKRMKAEAKT ISHMENKYMG LENKIISMQQ RIDELNRDNS 960
  961 NLKHKTSEIS VLKMKLELKK TLEAEFKNVK AACQDKDKLI EALNKQLEAE RDEKMQLLEE1020
 1021 NGHAQEEWIS QKQTWRQENE ELRRQIDEII DMAKNAEVNQ RNQEDRMLAE IDNRELNEAY1080
 1081 QRAIKDKEVI ENENFMLKEE LSRLTAGSFS LHARKASNAS SQNEDDVGYA SAKNTLDINR1140
 1141 PPDLLSKNYS YNDSTSLVVK LRSILEEEKQ KHKVLQEQYI KLSSRHKPTE DSFRVSELEV1200
 1201 ENEKLRSEYD QLRTSIKHGV EINELNAQHA ALQEEVRRRR EECIQLKAVL LQQSQSMRSL1260
 1261 EPESLQMRGN DVNELMEAFH SQKLINRQLE SELKAITEEH NSKLVEMTQE IERLNNEKDE1320
 1321 LQKVMFESID EFEDSNVDTL RQNDRYLRRE LQKAVAQFLL VQEELKLANA KLKAYRQDGG1380
 1381 QLEHKIEEEM IRNKSNGTSA DVGANVTKQK SQNPQGLMKF HSSDLDKILQ RLLSALTPRT1440
 1441 VVGLLPGFPA YLIFMCIRYT DLTNADDDVR ELLSKFVIQI KKMHRTPHPI ENRVIWLVNS1500
 1501 ITLLNLMKQY GDVDEYVKFN TEKQNQQQLK NFNLFEYRRV ILDLIVNLYQ ALIMQIQGLL1560
 1561 DPKIVPAILN NDEIQRGRQA HGMRSRATSI GASSSPEHGG GPAWKQLIGQ LEHFYKQFQH1620
 1621 FGLDNCYAEQ IFHQLLYFIC AVALNCLMLR GDICMWETGM IIRYNIGCIE DWVRSKKMSN1680
 1681 DVLTALAPLN QVSQLLQSRK SEQDVQTICD LCTSLSTAQV LKVMKSYKLD DYESEITNVF1740
 1741 LEKLTEKLNA RQMQKSNSDE FTIDQKFIQP FKVVFRYSDI KLEDIELPSH LNLDEFLTKI1800
 1801

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1064] PSI-BLAST 1000.0 No description for 2dfsA was found.
    2 View Details [1065..1211] FFAS03 1.37 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    3 View Details [1212..1384] PSI-BLAST 4.0 No description for 2i1jA was found.
    4 View Details [1385..1800] PSI-BLAST 38.0 Myosin V cargo binding domain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle