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Protein Overview: sPLA2-PA, sPLA2-PC

General Information:
Name(s) found: sPLA2-PC / FBpp0099486 [FlyBase]
sPLA2-PA / FBpp0099484 [FlyBase]
Description(s) found:
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  • gi|7304223|gb|AAF59258.1| secretory phospholipase A2, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|62471667|ref|NP_001014501.1| secretory phospholipase A2, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|61678430|gb|AAX52727.1| secretory phospholipase A2, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|35995669|gb|AAP45009.1| phospholipase A2 [Drosophila melanogaster] [NCBI NR]
  • gi|24586234|ref|NP_724556.1| secretory phospholipase A2, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|211938639|gb|ACJ13216.1| FI07253p [Drosophila melanogaster] [NCBI NR]
  • The gene secretory Phospholipase A2 is referred to in FlyBase by the symbol Dmel\sPLA2 (CG11124, FBgn0033170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3330369..3331348. It has the cytological map location 43C1. There is experimental evidence that it has the molecular function</span>: calcium-dependent phospholipase A2 activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: lipid catabolic process; phospholipid metabolic process. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG11124-PA translation from_gene[CG11124 CG11124 FBgn0033170] seq_release:3 mol_weight=21087 cds_boundaries:(2R:2,503,975..2,504,599[+]) aa_length:186 transcript_info:[CG11124-RA seq_release:3] gene_info:[gene symbol:CG11124 FBgn0033170 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V4L2) CG11124 protein [DrosMelano7227.FASTAC.txt]
  • (AE003841) CG11124 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • phospholipase A2 [Drosophila melanogaster]gi|7304223|gb|AAF59258.1| CG11124-PA, isoform A [Drosophila melanogaster]gi|24586234|ref|NP_724556.1| CG11124-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258; MD5=901cc [fly-100309-contam.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=90 [fly-100309-contam.fasta]
  • CG11124-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • phospholipase A2 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG11124-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • secretory Phospholipase A2 CG11124-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • secretory Phospholipase A2 CG11124-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • FI07253p OS=Drosophila melanogaster GN=sPLA2 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258,FlyMine:FBpp0099484,modMine:FBpp0099484; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(3330579..3330880,3330948..3331206); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • FI07253p OS=Drosophila melanogaster GN=sPLA2 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258,FlyMine:FBpp0099484,modMine:FBpp0099484; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258,FlyMine:FBpp0099484,modMine:FBpp0099484; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0099484 type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258,FlyMine:FBpp0099484,modMine:FBpp0099484; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0099486 type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099484; name=sPLA2-PA; parent=FBgn0033170,FBtr0088972; dbxref=FlyBase_Annotation_IDs:CG11124-PA,FlyBase:FBpp0099484,GB_protein:AAF59258.1,REFSEQ:NP_724556,GB_protein:AAF59258,UniProt/TrEMBL:Q6XPX3,FlyMine:FBpp0099484,modMine:FBpp0099484; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:join(7443074..7443375,7443443..7443701); ID=FBpp0099486; name=sPLA2-PC; parent=FBgn0033170,FBtr0100138; dbxref=FlyBase_Annotation_IDs:CG11124-PC,FlyBase:FBpp0099486,GB_protein:AAX52727.1,REFSEQ:NP_001014501,GB_protein:AAX52727,UniProt/TrEMBL:Q6XPX3; MD5=901cc165a537f66d57cc1494e40d4ce8; length=186; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 186 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IEA]
    Biological Process: lipid catabolic process [IEA]
    phospholipid metabolic process [IEA]
    Molecular Function: phospholipase A2 activity [ISS][NAS]
    calcium-dependent phospholipase A2 activity [IDA]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWLLREAFFF GLLAMAWAFG DEAIFEDEDI YNQALPPVPH TGITVPGTKW CGPGNTAANF  60
   61 EDLGRERETD KCCRAHDHCD EIIESHGALH GLPTNTDWFP ILKCTCEQQF INCLQAVNSI 120
  121 TAKTLGRIYY GSRSRCFANG HPTTGCKQYQ EGTFRKRCIR YQVDKSKAKV WQFYDMPFFT 180
  181 IPASAG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 54.045757 CRYSTAL STRUCTURE OF BEE-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.44512274794048 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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