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Protein Overview: gi|21645125, gi|...

General Information:
Name(s) found: gi|24586067 [NCBI NR]
gi|21645125 [NCBI NR]
Description(s) found:
Found 7 descriptions.
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  • gi|24586067|ref|NP_724495.1| Eb1, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|21645125|gb|AAM70825.1| Eb1, isoform C [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: spindle microtubule [IDA]
    cytoplasm [IDA]
    cytoplasmic microtubule [IDA]
    microtubule associated complex [ISS][TAS]
    microtubule [IDA]
    Biological Process: mitotic spindle elongation [IDA][IMP]
    spindle assembly [IDA]
    locomotory behavior [IMP]
    establishment of mitotic spindle localization [NAS][TAS]
    mitotic spindle organization [TAS]
    flight behavior [IMP]
    chromosome segregation [IDA]
    sensory organ development [IMP]
    pseudocleavage during syncytial blastoderm formation [IMP]
    microtubule-based process [ISS][TAS]
    Molecular Function: protein binding [IPI]
    microtubule binding [IEA][ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVNVYSTNV TSENLSRHDM LAWVNDCLQS QFSKIEELCT GAAYCQFMDM LFPNSVPVKR  60
   61 VKFRTNLEHE YIQNFKILQA GFKKMSVDKI IPVDKLIKGR FQDNFEFLQW FKKFFDANYD 120
  121 GREYDPVAQR GGVKLGNGNG HGSNGGSGVG SSNNDLHLMH RRPLQAPASG GRMPARVIAS 180
  181 TGTVLSKLRT PIIPIDKLVK GRFQDNFEFL QWFKKFFDAN YDGRDYDASA VREGAPMGFG 240
  241 SGAVKSLPGT AASGVSSSYR RGPSATTRPA MTSAVKPTVS KVLPRTNNAA PASRINACAN 300
  301 STGTVKKNDV SNSVNNQQIE EMSNQVMDMR INLEGLEKER DFYFSKLRDI EILCQEADDA 360
  361 EAHPIIQKIL DILYATEDGF APPDDAPPED EEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 76.0 Solution structure of the CH domain of human microtubule-associated protein RP/EB family member 3
    2 View Details [141..272] FFAS03 5.09 Southeast Collaboratory for Structural Genomics: Hypothetical Human Protein Q15691 N-Terminal Fragment
    3 View Details [273..393] PSI-BLAST 27.522879 Crystal structure of the EB1 C-terminal domain complexed with the CAP-Gly domain of p150Glued

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  6.0562477479739 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  5.72370607907493 bayes_pls_golite062009
  • microtubule binding
    		•  5.63808442303747 bayes_pls_golite062009
  • tubulin binding
    		•  5.63161872515663 bayes_pls_golite062009
  • actin binding
    		•  5.4843525466095 bayes_pls_golite062009
  • actin filament binding
    		•  3.58546515893973 bayes_pls_golite062009
  • binding
    		•  2.73681134719616 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.33067686982903 bayes_pls_golite062009
  • protein binding
    		•  2.17650965264372 bayes_pls_golite062009
  • structural molecule activity
    		•  0.952313983641982 bayes_pls_golite062009
  • dynein binding
    		•  0.282231591450947 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle