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Protein Overview: CG3267-PA

General Information:
Name(s) found: CG3267-PA / FBpp0085460 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG3267 (CG3267, FBgn0042083). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2633890..2636459. It has the cytological map location 42C8. Based on sequence similarity, it is predicted to have molecular function</span>: methylcrotonoyl-CoA carboxylase activity; CoA carboxylase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of eclosion. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 578 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    Biological Process: fatty acid catabolic process [NAS]
    methionine catabolic process [NAS]
    valine catabolic process [NAS]
    isoleucine catabolic process [NAS]
    regulation of eclosion [IMP]
    leucine metabolic process [ISS]
    threonine catabolic process [NAS]
    Molecular Function: propionyl-CoA carboxylase activity [NAS]
    methylcrotonoyl-CoA carboxylase activity [ISS]
    CoA carboxylase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRLNWLFRS SSVLLRSQVR LLHVGDANVL HSEVDKQSAE YKENAREMAS LVGDLRNFTS  60
   61 QVLKGGGQKA IERHTSRGKL LARERINLLL DKGSPFLELS ALAGHELYGE EVVNSGGIVT 120
  121 GVGRVCGTEC LVVANDATVK GGSYYPITVK KHLRAQEIAQ ENRLPCIYLV DSGGANLPRQ 180
  181 ADVFPDKLHF GRIFYNQANM SAQGIPQIAV VMGSCTAGGA YVPAMADESI IVKKQGTIFL 240
  241 AGPPLVKAAT GEEVSAEDLG GADLHCKTSG VTDHYALDDE HALYLARQIV SNLNLSATNS 300
  301 YNDQLMHSSQ VNFQTATPPS AVEEPRYDAE ELYGIVGPNL TKSFDVREVI ARIVDGSRFT 360
  361 EFKKLYGETL VCGFAKLYGH TVGIVGNNGV LFSESALKGA HFIQLCAQRK IPLVFLQNIT 420
  421 GFMVGRDAEA NGIAKNGAKM VTAVACANVP KFTVIIGGSY GAGNYGMCGR AYSPRFLYMW 480
  481 PNSRISVMGG TQAANVMAQI TEDQRKRAGK EFSEEEAQKL KAPIVEMFEA EGSPYYSTAR 540
  541 LWDDGIIDPA NTRQILGLSL KAALNNAGQE TKFGVFRM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..578] PSI-BLAST 158.0 Crystal structure of propionyl-CoA carboxylase, beta subunit (TM0716) from THERMOTOGA MARITIMA at 2.30 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • CoA carboxylase activity
    		•  4.38629333084302 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  4.36332808516753 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  4.29345455730254 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  3.92947460544831 bayes_pls_golite062009
  • methylcrotonoyl-CoA carboxylase activity
    		•  2.85169024122548 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  2.44182589784656 bayes_pls_golite062009
  • dodecenoyl-CoA delta-isomerase activity
    		•  1.80820904754223 bayes_pls_golite062009
  • catalytic activity
    		•  1.46154163027498 bayes_pls_golite062009
  • propionyl-CoA carboxylase activity
    		•  1.20853698666984 bayes_pls_golite062009
  • ligase activity
    		•  0.98581896521131 bayes_pls_golite062009
  • binding
    		•  0.578223105269736 bayes_pls_golite062009
  • 3-hydroxybutyryl-CoA epimerase activity
    		•  0.241955774397835 bayes_pls_golite062009
  • racemase and epimerase activity, acting on hydroxy acids and derivatives
    		•  0.099208209617217 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing C=C bonds
    		•  0.0918189681606029 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle