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Protein Overview: l(2)01289-PB

General Information:
Name(s) found: l(2)01289-PB / FBpp0085470 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene lethal (2) 01289 is referred to in FlyBase by the symbol Dmel\l(2)01289 (CG9432, FBgn0010482). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2608606..2628149. It has the cytological map location 42C6-42C7. Based on sequence similarity, it is predicted to have molecular function</span>: protein disulfide isomerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: cell redox homeostasis. 22 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1703 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS]
    Biological Process: cell redox homeostasis [IEA]
    Molecular Function: protein disulfide isomerase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTFTRLKTLS LLVCALLALS FPGHVSGAGN NNNKKGSQPV APPEPEAVIE EVNAKQLEKL  60
   61 LADKDYVAVF WYARSCVTCD KVLAELEKID DDTDSFGVDF VKINDKRLAK QYGIKNFPAL 120
  121 TYFREKEPII YDGDLMDEEG VLDFLTSLEA MDLPDRIEEV NAKILQKIIE DTDFVAVLFC 180
  181 PDHETCPPRV MDKQQCRKCA KALQELENID DEADQLGIGF VKIHDEALAD EYNLGNLPAL 240
  241 VYYRHQTPII YEGELQREED VLEWLVQNKS TGDEDDVIED VTSKTLSTLI SNIDNLVVLF 300
  301 YDHGNDDSMT VLEELEQIDD DCDKHGIQFV KIDDAKAAAD YGIDSIPAIV YFEKEIPNVY 360
  361 DGDLMDEEQI LKWLLGQLER DEIEDVTDEM LDTMIKEGRV IAVLFYDNND KKSQKVLEEL 420
  421 ENIDDECDAL GITFVKIDNP EEAVEYGINK VPKLIYFEKG IPTIYEGNLE DEEKLLKWLT 480
  481 DQTSSDQIED ITDEMLDLII EKMPHVAVLF YDKDQKKSQK ILAELENIDD ECDQNDIAFV 540
  541 KIDDDKEAKE WGIDEIPSIV LFERGIPHIY EGDLMKEDEL LGWLVHQKRY SEIPEVTDEM 600
  601 KDKLVENTEH LAVIFYDKDD KQDMRILNEL ENIDDELEKE GIVIVRIDNA AEAKEYGLDH 660
  661 LPALIYFENK IPALYEGDLM NEDEVLEWLL VQKKTATIEE VTDEILVTLI NEHEYVVVFF 720
  721 TGPCEPGETC EHTLNALESI DDELDEAGII FVTTEDTGIA KKYNVKTYPR LVFFRNRDPL 780
  781 HFTGDLDDED EVLAWITDDE TLEIPGKIEE VNVKMLDKIL AENDHVVVFF YAEGDKKAQK 840
  841 ILNELENIDD ECEEKDIDFV KTSDDDIDKE YDLPGLPALA FYRHKFRTIY TGDLMKEEEI 900
  901 LEWVIDLHES TADVIESVDR KTLQVLINDV EHLAVFFYDD ECESCSDILE ELENIDDDTD 960
  961 KHGIQFVKSN DVKLAHEIGI FAFPALVYYE TGVPIMYDGN IASNQDVFNW ILEQKADQSI1020
 1021 QLINRDQLFE YIGTKDFLAV VFYKEDDPDS PRVLRHIELI DDEAAEYGIY IVKMHDKLMA1080
 1081 KKYGFRNPPG LTYFRKGKYI NYDGDIDDEE EVLDWLTSPA NMEMTDHIEQ VNRKMFEKIR1140
 1141 KNSDYVAVIF YSDECKQCPR VLAEVEHIDD EADKAGIDFV KIDDKQMAKE YGVFALPAIV1200
 1201 FFKPTSKEPV IYAGDLYEEE QILTWLITQK DPSGDVIEDL EGERLVHLIE ESGSIAVYFY1260
 1261 ADGCEQCTKV LEELENIDDD CDKHGITFVK TRDFSVADGY GVHEYPALVY FEGGIPNVFE1320
 1321 GELSEEEEVL QWLITQKTED RIELITRQML ETMVEETQYL AVYFYKINCN ICDQILEGLE1380
 1381 LIDDECDVFG IHMVKIQDPQ LAKRYSIKTF PALVYFRNGN PLLFEGDLQN EQSVLEWLID1440
 1441 DDNRELADEI EEVNERMLDR LMAESTLLVV FFYDDDCAEC EEILEELEEI DGEADMFGID1500
 1501 FVKIASIQAA KKYEIVNIPS LVYFRKQVPV LYDGDLHQHD KVITWLTSQD VFEIKNEIEE1560
 1561 VNRKMLDKLL EENEFLAVFF YEHNQPDSTA ALEKLENIDS ETDNLDITFV KMADSRYAKK1620
 1621 WGVTKLPAMV YFRRRFPSIY RGDLLSEDEV LEWLRKNRFR QPELNIFMYA LIALAVAFVV1680
 1681 YTAFLLQCFK PAPPPPVQHP KQS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..377] PSI-BLAST 21.0 CRYSTAL STRUCTURE OF CALSEQUESTRIN FROM RABBIT SKELETAL MUSCLE SARCOPLASMIC RETICULUM AT 2.4 A RESOLUTION
    2 View Details [378..484] PSI-BLAST 17.0 Solution structure of the Thioredoxin h1 from poplar, a CPPC active site variant
    3 View Details [485..807] FFAS03 6.29 Crystal Structure of Yeast Protein Disulfide Isomerase
    4 View Details [808..1232] PSI-BLAST 68.522879 Crystal Structure of Yeast Protein Disulfide Isomerase
    5 View Details [1233..1453] PSI-BLAST 8.0 Protein disulfide isomerase, PDI
    6 View Details [1454..1546] PSI-BLAST 3.221849 Tryparedoxin I
    7 View Details [1547..1703] PSI-BLAST 4.0 Phosducin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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