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Protein Overview: Tdc1-PA

General Information:
Name(s) found: Tdc1-PA / FBpp0085476 [FlyBase]
Description(s) found:
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  • gi|28573972|ref|NP_610226.2| tyrosine decarboxylase 1 [Drosophila melanogaster] [NCBI NR]
  • gi|28380700|gb|AAM70810.2| tyrosine decarboxylase 1 [Drosophila melanogaster] [NCBI NR]
  • gi|201065549|gb|ACH92184.1| FI02861p [Drosophila melanogaster] [NCBI NR]
  • The gene Tyrosine decarboxylase 1 is referred to in FlyBase by the symbol Dmel\Tdc1 (CG30445, FBgn0259977). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2564501..2567891. It has the cytological map location 42C4. There is experimental evidence that it has the molecular function</span>: tyrosine decarboxylase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: carboxylic acid metabolic process; cellular amino acid and derivative metabolic process. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG30445-PA translation from_gene[CG30445 CG30445 FBgn0050445] seq_release:3 mol_weight=65687 cds_boundaries:(2R:1,738,211..1,741,081[-]) aa_length:587 transcript_info:[CG30445-RA seq_release:3] gene_info:[gene symbol:CG30445 synonyms:[CG3686] FBgn0050 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V9B8) CG30445-PA [DrosMelano7227.FASTAC.txt]
  • CG30445-PA [Drosophila melanogaster]gi|28573972|ref|NP_610226.2| CG30445-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(2564811..2565339,2565462..2566566,2567555..2567684); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_prote [fly-100309-contam.fasta]
  • CG30445-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Tyrosine decarboxylase 1 CG30445-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(2564811..2565339,2565462..2566566,2567555..2567684); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(2564811..2565339,2565462..2566566,2567555..2567684); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • FI02861p OS=Drosophila melanogaster GN=Tdc1 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(2564811..2565339,2565462..2566566,2567555..2567684); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810,FlyMine:FBpp0085476,modMine:FBpp0085476; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(6680050..6680179,6677957..6679061,6677306..6677834)); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810,FlyMine:FBpp0085476,modMine:FBpp0085476; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(6680050..6680179,6677957..6679061,6677306..6677834)); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810,FlyMine:FBpp0085476,modMine:FBpp0085476; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0085476 type=protein; loc=2R:complement(join(6680050..6680179,6677957..6679061,6677306..6677834)); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810,FlyMine:FBpp0085476,modMine:FBpp0085476; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(6680050..6680179,6677957..6679061,6677306..6677834)); ID=FBpp0085476; name=Tdc1-PA; parent=FBgn0259977,FBtr0086143; dbxref=FlyBase:FBpp0085476,FlyBase_Annotation_IDs:CG30445-PA,GB_protein:AAM70810.2,REFSEQ:NP_610226,GB_protein:AAM70810,UniProt/TrEMBL:A1Z6N2,FlyMine:FBpp0085476,modMine:FBpp0085476; MD5=f2b1b1a02d99ba4f9ea33eb3167f1c02; length=587; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 587 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: cellular amino acid and derivative metabolic process [IEA]
    carboxylic acid metabolic process [IEA]
    Molecular Function: pyridoxal phosphate binding [IEA]
    tyrosine decarboxylase activity [IDA][ISS]
    aromatic-L-amino-acid decarboxylase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVEEFRKYG KEVIDYICQY GTNIEERDVA PTLDPGYLKK LLPADAPQSP EPFKDVLEDF  60
   61 EQKIMPGVVH WNHPKFFAYF PSGNSFPSVL GDMLSSAIGS IGFSWASCPA AAELETIVMN 120
  121 WYAKALGLPK AFVSDAPGST GGGALQGSAS ECVLVSLITA RARAISELKG QTSVHDSVFL 180
  181 PSLIAYASRE AHSSVEKATK MALVKLRIID ADEHGRMRVD LLRQAIQNDV NAGLTPFFVV 240
  241 ATVGTTGGCA FDDITEIGKV CRQVSSIWLH VDGAYAGNSF ILPEMRVFSA GLEYADSFNT 300
  301 NPNKLLLTNF DASALWVRDV MNLKSALNVN PLYLRHEHLT GVDYRHYGIP LSRRFRALKL 360
  361 WFVFRTYGIR GLQEYIRNHM ALAKKFEMLV RKDERFEVRN DVHLGLVCFR MRTGDEPNHM 420
  421 LLAQINHSGK MHMTPAKFNG RYVIRFCVTY EHATEKDILE AWTQIKCFAE EILRDHQLES 480
  481 SSVPTTPEGS ERTSSEPLAP VAGKPPIKKR LTRTKSLRFS FTRSISREQY QSQSEHLMDG 540
  541 CTPILVVDPK TLQENFQKAA DDNDRNNSNG NVKLKDISDV DTDEASN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..50] PSI-BLAST 110.0 DOPA decarboxylase
    2 View Details [51..587] PSI-BLAST 24.0 Serine hydroxymethyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  1.01853440922526 bayes_pls_golite062009
  • transferase activity
    		•  0.737426388870721 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  0.130698724135981 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.11598778799668 bayes_pls_golite062009
  • aromatic-L-amino-acid decarboxylase activity
    		•  0.10589462882093 bayes_pls_golite062009
  • binding
    		•  0.0138724523355769 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle