Protein Overview: Sos-PA

General Information:
Name(s) found:	Sos-PA / FBpp0080118 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|76800652\|sp\|P26675.2\|SOS_DROME RecName: Full=Protein son of sevenless [NCBI NR] gb\|AAF44820.1\| symbol=Sos; synonym=BG:DS00941.4; match=method:''sim4'', score:''1000.0'', desc:''GenBank::M83931:Drosophila melanogaster son of sevenless (Sos) mRNA, complete cds. CDS:346..5133; PID:g158485.'', species:''Drosophila melanogaster''; match=m [NCBI NR] gi\|22946434\|gb\|AAF53336.2\| Son of sevenless [Drosophila melanogaster] [NCBI NR] gi\|18110536\|ref\|NP_476597.2\| Son of sevenless [Drosophila melanogaster] [NCBI NR] gi\|158471\|gb\|AAA28904.1\| putative guanine nucleotide exchange factor; putative [Drosophila melanogaster] [NCBI NR] pir\|\|A41216 guanine nucleotide exchange activator son-of-sevenless - fruit fly (Drosophila melanogaster) [NCBI NR] Protein son of sevenless OS=Drosophila melanogaster GN=Sos PE=1 SV=2 [Swiss-Prot] The gene Son of sevenless is referred to in FlyBase by the symbol Dmel\Sos (CG7793, FBgn0001965). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:13813828..13819826. It has the cytological map location 34D1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; negative regulation of S phase of mitotic cell cycle; tracheal outgrowth, open tracheal system; actin filament organization. 89 alleles are reported. The phenotypes of these alleles are annotated with 31 unique terms, many of which group under: peripheral nervous system; nervous system; external compound sense organ; embryonic neuron; embryonic nervous system; larval abdominal segment 5; abdominal lateral pentascolopidial chordotonal organ lch5; organ system; multi-cell-component structure; compound cell cluster organ. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG7793-PA translation from_gene[CG7793 Sos FBgn0001965] seq_release:3 mol_weight=177936 cds_boundaries:(2L:13,796,366..13,801,527[+]) aa_length:1596 transcript_info:[CG7793-RA seq_release:3] gene_info:[gene symbol:Sos FBgn0001965 gene_boundaries:(2L:1 [hmr_yeast5_DM3-1_pombe.fasta] (Q9VJV9) CG7793 protein (Sos protein) [DrosMelano7227.FASTAC.txt] CG7793-PA [Drosophila melanogaster]gi\|7287782\|gb\|AAF44820.1\| symbol=Sos; synonym=BG:DS00941.4; match=method:''sim4'', score:''1000.0'', desc:''GenBank::M83931:Drosophila melanogaster son of sevenless (Sos) mRNA, complete cds. CDS:346..5133; PID:g158485.' [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBas [fly-100309-contam.fasta] putative guanine nucleotide exchange factor; putative [nr-271106-contam.fasta] Protein son of sevenless [nr-271106-contam.fasta] Son of sevenless CG7793-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG7793-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336,FlyMine:FBpp0080118,modMine:FBpp0080118; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336,FlyMine:FBpp0080118,modMine:FBpp0080118; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336,FlyMine:FBpp0080118,modMine:FBpp0080118; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0080118 type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336,FlyMine:FBpp0080118,modMine:FBpp0080118; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:join(13814214..13815305,13815359..13815716,13815779..13816701,13816766..13817614,13817677..13818567,13818636..13819269,13819335..13819378); ID=FBpp0080118; name=Sos-PA; parent=FBgn0001965,FBtr0080541; dbxref=FlyBase:FBpp0080118,FlyBase_Annotation_IDs:CG7793-PA,GB_protein:AAF53336.2,REFSEQ:NP_476597,GB_protein:AAF53336,UniProt/Swiss-Prot:P26675,FlyMine:FBpp0080118,modMine:FBpp0080118; MD5=577dec1b403bd231629f465f01a89da0; length=1596; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1596 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of cell shape [IMP] torso signaling pathway [TAS] regulation of Rho protein signal transduction [IEA] negative regulation of S phase of mitotic cell cycle [IMP] anterior/posterior axis specification, embryo [TAS] nervous system development [NAS] sevenless signaling pathway [TAS] actin filament organization [IMP] Ras protein signal transduction [ISS] tracheal outgrowth, open tracheal system [IMP]
Molecular Function:	DNA binding [IEA] protein binding [IPI] Ras guanyl-nucleotide exchange factor activity [ISS][NAS] Rho guanyl-nucleotide exchange factor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA GLQDCDGYDF  60
   61 TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK LCLRLLAMLC AKPLPHSVQD 120
  121 VEEKVNKSFP APIDQWALNE AKEVINSKKR KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL 180
  181 VAVLEYISAD ILKMAGDYVI KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL 240
  241 PAQRASATYE ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE 300
  301 VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ ASRDALNNLL 360
  361 SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY IKHLKDLSSS QDDIESFEQV 420
  421 QGLLHPLHCD LEKVMASLSK ERQVPVSGRV RRQLAIERTR ELQMKVEHWE DKDVGQNCNE 480
  481 FIREDSLSKL GSGKRIWSER KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR 540
  541 VDINDRPDSD DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL 600
  601 QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI ERLTYHIYAD 660
  661 PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT GTAGAGGMGG VGGDKEHKNS 720
  721 HREDWKRYRK EYVQPVQFRV LNVLRHWVDH HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW 780
  781 VDSVLKIVQR KNEQEKSNKK IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL 840
  841 EFEMYKNVKP SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI 900
  901 MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL EECRELSDDH 960
  961 LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT ELINFSKRRK VAEIIGEIQQ1020
 1021 YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK QMSDYLYNES LRIEPRGCKT VPKFPRKWPH1080
 1081 IPLKSPGIKP RRQNQTNSSS KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT1140
 1141 AAAANAGSGT LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA1200
 1201 PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS DTEAPPSPLP1260
 1261 KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS GGEEFCAGGF YFNSAHQGQP1320
 1321 GAVPISPHVN VPMATNMEYR AVPPPLPPRR KERTESCADM AQKRQAPDAP TLPPRDGELS1380
 1381 PPPIPPRLNH STGISYLRQS HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN1440
 1441 QAAAGPISTT LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST1500
 1501 SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS SPKEFFPIAT1560
 1561 SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.64

Protein Overview: Sos-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: