Protein Overview: CG6523-PA

General Information:
Name(s) found:	CG6523-PA / FBpp0080044 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	This gene is referred to in FlyBase by the symbol Dmel\CG6523 (CG6523, FBgn0032509). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:13366466..13367410. It has the cytological map location 34B7. Based on sequence similarity, it is predicted to have molecular function</span>: disulfide oxidoreductase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: cell redox homeostasis. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	216 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	cell redox homeostasis [IEA]
Molecular Function:	disulfide oxidoreductase activity [ISS] protein disulfide oxidoreductase activity [IEA] electron carrier activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVVNVSAAE EYQKYINADK TTVALFAAEW AEQCGQVKDA LEELAKITGE KLQFISLNAE  60
   61 QFPEISMKHQ IEAVPTVIFF AKGSAVDRVD GVDIAAISAK SKKLAENASS AAATGQTLEE 120
  121 RLKALINTAP LMIFMKGDRN GPRCGFSKQL IGIVNETNLP YETFDILGDE EVRQGLKTYS 180
  181 DWPTYPQVYV KGELIGGLDI IKELLANNEL ESTLKG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..108]	PSI-BLAST	27.045757	Thioredoxin
2	View Details	[109..216]	PSI-BLAST	15.30103	Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
antioxidant activity	3.66884588063322	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.8187537496904	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
selenium binding	1.1082524159827	bayes_pls_golite062009
binding	1.05954762746883	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
transcription regulator activity	0.26464693774353	bayes_pls_golite062009
protein binding	0.034515546627104	bayes_pls_golite062009

2

Term	Confidence	Notes
antioxidant activity	3.66884588063322	bayes_pls_golite062009
peroxidase activity	3.43831566988273	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	3.43831566988273	bayes_pls_golite062009
glutathione peroxidase activity	2.56524997297011	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.8187537496904	bayes_pls_golite062009
protein disulfide oxidoreductase activity	1.47769936616412	bayes_pls_golite062009
disulfide oxidoreductase activity	1.32811008894503	bayes_pls_golite062009
selenium binding	1.1082524159827	bayes_pls_golite062009
binding	1.05954762746883	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009
transcription regulator activity	0.26464693774353	bayes_pls_golite062009
protein binding	0.034515546627104	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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