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Protein Overview: CYLD-PB

General Information:
Name(s) found: CYLD-PB / FBpp0079661 [FlyBase]
Description(s) found:
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  • gi|24583328|ref|NP_723556.1| CYLD, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|22946130|gb|AAN10741.1| CYLD, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene cylindromatosis is referred to in FlyBase by the symbol Dmel\CYLD (CG5603, FBgn0032210). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:10295856..10299827. It has the cytological map location 31C7-31D1. There is experimental evidence that it has the molecular function</span>: ubiquitin-specific protease activity. There is experimental evidence that it is involved in the biological process</span>: protein deubiquitination; defense response to bacterium; acylglycerol homeostasis. 8 alleles are reported. The phenotypes of these alleles are annotated with: adult fat body; lipid particle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • >CG5603-PB translation from_gene[CG5603 CG5603 FBgn0032210] seq_release:3 mol_weight=62316 cds_boundaries:(2L:10,288,329..10,290,537[-]) aa_length:551 transcript_info:[CG5603-RB seq_release:3] gene_info:[gene symbol:CG5603 FBgn0032210 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IPC3) CG5603-PB [DrosMelano7227.FASTAC.txt]
  • CG5603-PB, isoform B [Drosophila melanogaster]gi|24583328|ref|NP_723556.1| CG5603-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298023..10298128); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,F [fly-100309-contam.fasta]
  • CG5603-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CYLD CG5603-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298023..10298128); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298023..10298128); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Cylindromatosis, isoform B OS=Drosophila melanogaster GN=CYLD PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298023..10298128); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741,FlyMine:FBpp0079661,modMine:FBpp0079661; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2L:complement(join(10298023..10298128,10297705..10297936,10297431..10297606,10297216..10297370,10296938..10297156,10296625..10296859,10296424..10296565,10296172..10296368,10295917..10296110)); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741,FlyMine:FBpp0079661,modMine:FBpp0079661; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2L:complement(join(10298023..10298128,10297705..10297936,10297431..10297606,10297216..10297370,10296938..10297156,10296625..10296859,10296424..10296565,10296172..10296368,10295917..10296110)); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741,FlyMine:FBpp0079661,modMine:FBpp0079661; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q8IPC5, Cylindromatosis ortholog, isoform B OS=Drosophila melanogaster GN=CYLD PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0079661 type=protein; loc=2L:complement(join(10298023..10298128,10297705..10297936,10297431..10297606,10297216..10297370,10296938..10297156,10296625..10296859,10296424..10296565,10296172..10296368,10295917..10296110)); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741,FlyMine:FBpp0079661,modMine:FBpp0079661; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2L:complement(join(10298023..10298128,10297705..10297936,10297431..10297606,10297216..10297370,10296938..10297156,10296625..10296859,10296424..10296565,10296172..10296368,10295917..10296110)); ID=FBpp0079661; name=CYLD-PB; parent=FBgn0032210,FBtr0080072; dbxref=FlyBase:FBpp0079661,FlyBase_Annotation_IDs:CG5603-PB,GB_protein:AAN10741.1,REFSEQ:NP_723556,GB_protein:AAN10741,UniProt/TrEMBL:Q8IPC3,FlyMine:FBpp0079661,modMine:FBpp0079661; MD5=d26e9aacd583e49c7a5e74eb9b6ca00c; length=551; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 551 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    ribosome [IEA]
    Biological Process: protein deubiquitination [IDA]
    acylglycerol homeostasis [IMP]
    defense response to bacterium [IMP]
    ubiquitin-dependent protein catabolic process [IEA]
    translation [IEA]
    Molecular Function: ubiquitin-specific protease activity [IDA]
    transcription factor activity [ISS]
    structural constituent of ribosome [IEA]
    ubiquitin thiolesterase activity [IEA][ISS]
    microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIYQQKLSS DSDIHNNIPL TVLEFYSPNL LPEELGFTIA DYQPLIEIPG TELAIGSLVE  60
   61 VSNPGVCEDL YGVVRWIGIP PGPQKNVLVG IEVEDESNLK NVVASDGRHN GVRLFTCHDG 120
  121 RAIFVPANRC TADRRFADVD NSISANRVSS NHAKKFGVAD CPAIYGSIPP LQIHNSDELA 180
  181 SICGKFKGIQ GHHNSCYLDA TLFSMFTFTS VFDSILYRRP GPQDIRNYSE VQKVLRDEIV 240
  241 NPLRKNVFVR SDRVMKLREL LDQLSSVSGL TCEEKDPEEF LNSLLSQIMR VEPFLKLSSG 300
  301 QDSYFYQLFV EKDEKLTLPS VQQLFEQSFH SSDIKLKEVP SCFIIQMPRF GKNYKMYPRI 360
  361 LPSQVLDVTD IIENSPRQCS LCGKLAEYEC RDCFGSLQAG SGLECTAFCP KCLKTFHSHI 420
  421 KRTNHVSKKI YSPKEFKIMA EHMVVPRLYM ELFAVVCIET SHYVAFVKSG SGPDAPWCFF 480
  481 DSMADRKGEQ NGYNIPEITC VPELTQWLSE EGARSINETS TNDKVLPEHA KRIFCDAYMC 540
  541 LYQSTDIMMY H

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle