Protein Overview: CYLD-PC

General Information:
Name(s) found:	CYLD-PC / FBpp0079658 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|24583326\|ref\|NP_723555.1\| CYLD, isoform C [Drosophila melanogaster] [NCBI NR] gi\|22946129\|gb\|AAN10740.1\| CYLD, isoform C [Drosophila melanogaster] [NCBI NR] The gene cylindromatosis is referred to in FlyBase by the symbol Dmel\CYLD (CG5603, FBgn0032210). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:10295856..10299827. It has the cytological map location 31C7-31D1. There is experimental evidence that it has the molecular function</span>: ubiquitin-specific protease activity. There is experimental evidence that it is involved in the biological process</span>: protein deubiquitination; defense response to bacterium; acylglycerol homeostasis. 8 alleles are reported. The phenotypes of these alleles are annotated with: adult fat body; lipid particle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] >CG5603-PC translation from_gene[CG5603 CG5603 FBgn0032210] seq_release:3 mol_weight=62084 cds_boundaries:(2L:10,288,329..10,291,292[-]) aa_length:550 transcript_info:[CG5603-RC seq_release:3] gene_info:[gene symbol:CG5603 FBgn0032210 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta] (Q8IPC4) CG5603-PC [DrosMelano7227.FASTAC.txt] CG5603-PC, isoform C [Drosophila melanogaster]gi\|24583326\|ref\|NP_723555.1\| CG5603-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298883); ID=FBpp0079658; name=CYLD-PC; parent=FBgn0032210,F [fly-100309-contam.fasta] CG5603-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] CYLD CG5603-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298883); ID=FBpp0079658; name=CYLD-PC; parent=FBgn0032210,FBtr0080069; dbxref=FlyBase:FBpp0079658,FlyBase_Annotation_IDs:CG5603-PC,GB_protein:AAN10740.1,REFSEQ:NP_723555,GB_protein:AAN10740; MD5=fc34377f80d20b6e97214b143bcc19ff; length=550; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298883); ID=FBpp0079658; name=CYLD-PC; parent=FBgn0032210,FBtr0080069; dbxref=FlyBase:FBpp0079658,FlyBase_Annotation_IDs:CG5603-PC,GB_protein:AAN10740.1,REFSEQ:NP_723555,GB_protein:AAN10740; MD5=fc34377f80d20b6e97214b143bcc19ff; length=550; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Cylindromatosis, isoform C OS=Drosophila melanogaster GN=CYLD PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:complement(10295917..10296110,10296172..10296368,10296424..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298883); ID=FBpp0079658; name=CYLD-PC; parent=FBgn0032210,FBtr0080069; dbxref=FlyBase:FBpp0079658,FlyBase_Annotation_IDs:CG5603-PC,GB_protein:AAN10740.1,REFSEQ:NP_723555,GB_protein:AAN10740,FlyMine:FBpp0079658,modMine:FBpp0079658; MD5=fc34377f80d20b6e97214b143bcc19ff; length=550; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
Organism:	Drosophila melanogaster
Length:	550 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS] ribosome [IEA]
Biological Process:	protein deubiquitination [IDA] acylglycerol homeostasis [IMP] defense response to bacterium [IMP] ubiquitin-dependent protein catabolic process [IEA] translation [IEA]
Molecular Function:	ubiquitin-specific protease activity [IDA] transcription factor activity [ISS] structural constituent of ribosome [IEA] ubiquitin thiolesterase activity [IEA][ISS] microtubule binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILNNKSKTD PSNSVDLILK PASPILKIEP EEPLRFTIAD YQPLIEIPGT ELAIGSLVEV  60
   61 SNPGVCEDLY GVVRWIGIPP GPQKNVLVGI EVEDESNLKN VVASDGRHNG VRLFTCHDGR 120
  121 AIFVPANRCT ADRRFADVDN SISANRVSSN HAKKFGVADC PAIYGSIPPL QIHNSDELAS 180
  181 ICGKFKGIQG HHNSCYLDAT LFSMFTFTSV FDSILYRRPG PQDIRNYSEV QKVLRDEIVN 240
  241 PLRKNVFVRS DRVMKLRELL DQLSSVSGLT CEEKDPEEFL NSLLSQIMRV EPFLKLSSGQ 300
  301 DSYFYQLFVE KDEKLTLPSV QQLFEQSFHS SDIKLKEVPS CFIIQMPRFG KNYKMYPRIL 360
  361 PSQVLDVTDI IENSPRQCSL CGKLAEYECR DCFGSLQAGS GLECTAFCPK CLKTFHSHIK 420
  421 RTNHVSKKIY SPKEFKIMAE HMVVPRLYME LFAVVCIETS HYVAFVKSGS GPDAPWCFFD 480
  481 SMADRKGEQN GYNIPEITCV PELTQWLSEE GARSINETST NDKVLPEHAK RIFCDAYMCL 540
  541 YQSTDIMMYH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: CYLD-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: