Protein Overview: CYLD-PA

General Information:
Name(s) found:	CYLD-PA / FBpp0079657 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7297649\|gb\|AAF52901.1\| CYLD, isoform A [Drosophila melanogaster] [NCBI NR] gi\|24583330\|ref\|NP_723557.1\| CYLD, isoform A [Drosophila melanogaster] [NCBI NR] The gene cylindromatosis is referred to in FlyBase by the symbol Dmel\CYLD (CG5603, FBgn0032210). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:10295856..10299827. It has the cytological map location 31C7-31D1. There is experimental evidence that it has the molecular function</span>: ubiquitin-specific protease activity. There is experimental evidence that it is involved in the biological process</span>: protein deubiquitination; defense response to bacterium; acylglycerol homeostasis. 8 alleles are reported. The phenotypes of these alleles are annotated with: adult fat body; lipid particle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] >CG5603-PA translation from_gene[CG5603 CG5603 FBgn0032210] seq_release:3 mol_weight=58082 cds_boundaries:(2L:10,288,811..10,291,613[-]) aa_length:517 transcript_info:[CG5603-RA seq_release:3] gene_info:[gene symbol:CG5603 FBgn0032210 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta] (Q9VL04) CG5603 protein [DrosMelano7227.FASTAC.txt] (AE003628) CG5603 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG5603-PA, isoform A [Drosophila melanogaster]gi\|24583330\|ref\|NP_723557.1\| CG5603-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(10296399..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298989,10299044..10299204); ID=FBpp0079657; name=CYLD-PA; parent=FBgn0032210,FBtr0080068; dbxref= [fly-100309-contam.fasta] CG5603-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] CYLD CG5603-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(10296399..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298989,10299044..10299204); ID=FBpp0079657; name=CYLD-PA; parent=FBgn0032210,FBtr0080068; dbxref=FlyBase:FBpp0079657,FlyBase_Annotation_IDs:CG5603-PA,GB_protein:AAF52901.1,REFSEQ:NP_723557,GB_protein:AAF52901; MD5=8b032db49c54cad58ff5da3aba04dbf0; length=517; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(10296399..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298989,10299044..10299204); ID=FBpp0079657; name=CYLD-PA; parent=FBgn0032210,FBtr0080068; dbxref=FlyBase:FBpp0079657,FlyBase_Annotation_IDs:CG5603-PA,GB_protein:AAF52901.1,REFSEQ:NP_723557,GB_protein:AAF52901; MD5=8b032db49c54cad58ff5da3aba04dbf0; length=517; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Cylindromatosis, isoform A OS=Drosophila melanogaster GN=CYLD PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:complement(10296399..10296565,10296625..10296859,10296938..10297156,10297216..10297370,10297431..10297606,10297705..10297936,10298781..10298989,10299044..10299204); ID=FBpp0079657; name=CYLD-PA; parent=FBgn0032210,FBtr0080068; dbxref=FlyBase:FBpp0079657,FlyBase_Annotation_IDs:CG5603-PA,GB_protein:AAF52901.1,REFSEQ:NP_723557,GB_protein:AAF52901,FlyMine:FBpp0079657,modMine:FBpp0079657; MD5=8b032db49c54cad58ff5da3aba04dbf0; length=517; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
Organism:	Drosophila melanogaster
Length:	517 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS] ribosome [IEA]
Biological Process:	protein deubiquitination [IDA] acylglycerol homeostasis [IMP] defense response to bacterium [IMP] ubiquitin-dependent protein catabolic process [IEA] translation [IEA]
Molecular Function:	ubiquitin-specific protease activity [IDA] transcription factor activity [ISS] structural constituent of ribosome [IEA] ubiquitin thiolesterase activity [IEA][ISS] microtubule binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSKSDYEAE KEKKLTITNR FGDSLENYEL SNESEHKTHV YPKKIPNRKN GILKNTDANH  60
   61 SAVDNQHLED VDLADILGTN WPKRAGPAAM ILNNKSKTDP SNSVDLILKP ASPILKIEPE 120
  121 EPLRFTIADY QPLIEIPGTE LAIGSLVEVS NPGVCEDLYG VVRWIGIPPG PQKNVLVGIE 180
  181 VEDESNLKNV VASDGRHNGV RLFTCHDGRA IFVPANRCTA DRRFADVDNS ISANRVSSNH 240
  241 AKKFGVADCP AIYGSIPPLQ IHNSDELASI CGKFKGIQGH HNSCYLDATL FSMFTFTSVF 300
  301 DSILYRRPGP QDIRNYSEVQ KVLRDEIVNP LRKNVFVRSD RVMKLRELLD QLSSVSGLTC 360
  361 EEKDPEEFLN SLLSQIMRVE PFLKLSSGQD SYFYQLFVEK DEKLTLPSVQ QLFEQSFHSS 420
  421 DIKLKEVPSC FIIQMPRFGK NYKMYPRILP SQVLDVTDII ENSPRQCSLC GKLAEYECRD 480
  481 CFGSLQAGSG LECTAFCPKC LKTFHSHIKR SAIFIDK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: CYLD-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: