Protein Overview: gkt-PA

General Information:
Name(s) found:	gkt-PA / FBpp0077263 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7295840\|gb\|AAF51141.1\| glaikit [Drosophila melanogaster] [NCBI NR] gi\|37999816\|sp\|Q9VQM4.1\|TYDP1_DROME RecName: Full=Probable tyrosyl-DNA phosphodiesterase; Short=Tyr-DNA phosphodiesterase; AltName: Full=Protein glaikit [NCBI NR] gi\|24581359\|ref\|NP_523465.2\| glaikit [Drosophila melanogaster] [NCBI NR] gi\|15292079\|gb\|AAK93308.1\| LD37277p [Drosophila melanogaster] [NCBI NR] (Q9VQM4) Probable tyrosyl-DNA phosphodiesterase (EC 3.1.4.-) (Tyr-DNA phosphodiesterase) (Glaikit protein) [Swiss-Prot] Probable tyrosyl-DNA phosphodiesterase OS=Drosophila melanogaster GN=gkt PE=2 SV=1 [Swiss-Prot] The gene glaikit is referred to in FlyBase by the symbol Dmel\gkt (CG8825, FBgn0260817). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:3159956..3162403. It has the cytological map location 23D4. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: phosphoric diester hydrolase activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; establishment or maintenance of epithelial cell apical/basal polarity. 7 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; ventral nerve cord commissure; longitudinal connective; embryonic central nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG8825-PA translation from_gene[CG8825 Tdp1 FBgn0031506] seq_release:3 mol_weight=64195 cds_boundaries:(2L:3,152,642..3,154,610[+]) aa_length:580 transcript_info:[CG8825-RA seq_release:3] gene_info:[gene symbol:Tdp1 synonyms:[CG8826] FBgn0031506 gene_ [hmr_yeast5_DM3-1_pombe.fasta] (AE003580) glaikit gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG8825-PA [Drosophila melanogaster]gi\|15292079\|gb\|AAK93308.1\| LD37277p [Drosophila melanogaster]gi\|24581359\|ref\|NP_523465.2\| CG8825-PA [Drosophila melanogaster]gi\|37999816\|sp\|Q9VQM4\|TYDP_DROME Probable tyrosyl-DNA phosphodiesterase (Tyr-DNA phosphodies [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0031506,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1 [fly-100309-contam.fasta] glaikit CG8825-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Probable tyrosyl-DNA phosphodiesterase (Tyr-DNA phosphodiesterase) (Protein glaikit) [nr-271106-contam.fasta] LD37277p [Drosophila melanogaster] [nr-271106-contam.fasta] CG8825-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0031506,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0260817,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0260817,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141,FlyMine:FBpp0077263,modMine:FBpp0077263; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0260817,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141,FlyMine:FBpp0077263,modMine:FBpp0077263; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0260817,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141,FlyMine:FBpp0077263,modMine:FBpp0077263; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0077263 type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0260817,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141,FlyMine:FBpp0077263,modMine:FBpp0077263; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:join(3160073..3160148,3160203..3160749,3160810..3161199,3161255..3161852,3161913..3162044); ID=FBpp0077263; name=gkt-PA; parent=FBgn0260817,FBtr0077574; dbxref=FlyBase:FBpp0077263,FlyBase_Annotation_IDs:CG8825-PA,GB_protein:AAF51141.1,REFSEQ:NP_523465,GB_protein:AAF51141,UniProt/Swiss-Prot:Q9VQM4,FlyMine:FBpp0077263,modMine:FBpp0077263; MD5=752d1d5ebbbfb0163a1b9a744a01a2c2; length=580; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	580 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA]
Biological Process:	DNA repair [IEA] central nervous system development [IMP] establishment or maintenance of epithelial cell apical/basal polarity [IMP]
Molecular Function:	phosphoric diester hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKECPYGEKC YRKNPIHFGE FSHAHLDAIY AKGNESGDYE IPANYSSEMI HTQLKLLEKL  60
   61 FPKQATNKEQ EAHSSSSKPA VTAPVASGSS SSGSLDTNPS GSSASGPAAS QDTSNLAKKQ 120
  121 KLNAKNIRDY IPVVIEKGGM AKKLERAAPY NMFLTAITDS KPTHSEPLSI TLQEILDESL 180
  181 GEIESTVQIN FMVDIGWLLG HYYFAGILDK PLLLLYGDES PELLSIGKFK QQVTAIRVKM 240
  241 PTPFATSHTK MMFLGYSDGS MRVVISTANL YEDDWHNRTQ GLWISPKLPA LPVDADTGAG 300
  301 ESLTGFKQDL MLYLVEYKIS QLQPWIARIR NSDFSAINVF FLGSVPGGHR EGSVRGHPWG 360
  361 HARLASLLAK HAAPIDDRIP VVCQSSSIGS LGANVQAWIQ QDFVNSLKKD STPVGKLRQM 420
  421 PPFKMIYPSY GNVAGSHDGM LGGGCLPYGK NTNDKQPWLK DYLQQWKSSD RFRSRAMPHI 480
  481 KSYTRFNLED QSVYWFVLTS ANLSKAAWGC FNKNSNIQPC LRIANYEAGV LFLPRFVTGE 540
  541 DTFPLGNNRD GVPAFPLPYD VPLTPYAPDD KPFLMDYLQG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: gkt-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: