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Protein Overview: Prx6005-PA

General Information:
Name(s) found: Prx6005-PA / FBpp0077368 [FlyBase]
Description(s) found:
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  • gi|7295884|gb|AAF51184.1| peroxiredoxin 6005 [Drosophila melanogaster] [NCBI NR]
  • gi|24581278|ref|NP_523463.2| peroxiredoxin 6005 [Drosophila melanogaster] [NCBI NR]
  • The gene Peroxiredoxin 6005 is referred to in FlyBase by the symbol Dmel\Prx6005 (CG3083, FBgn0031479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:2877091..2878149. It has the cytological map location 23C1. There is experimental evidence that it has the molecular function</span>: thioredoxin peroxidase activity. There is experimental evidence that it is involved in the biological process</span>: hydrogen peroxide catabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG3083-PA translation from_gene[CG3083 Prx6005 FBgn0031479] seq_release:3 mol_weight=24846 cds_boundaries:(2L:2,869,760..2,870,706[-]) aa_length:222 transcript_info:[CG3083-RA seq_release:3] gene_info:[gene symbol:Prx6005 FBgn0031479 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VQI7) CG3083 protein [DrosMelano7227.FASTAC.txt]
  • (AE003581) CG3083 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG3083-PA [Drosophila melanogaster]gi|24581278|ref|NP_523463.2| CG3083-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2L:complement(2877188..2877389,2877611..2877803,2877864..2878137); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_pro [fly-100309-contam.fasta]
  • CG3083-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Peroxiredoxin 6005 CG3083-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2L:complement(2877188..2877389,2877611..2877803,2877864..2878137); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2L:complement(2877188..2877389,2877611..2877803,2877864..2878137); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Peroxiredoxin 6005 OS=Drosophila melanogaster GN=Prx6005 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2L:complement(2877188..2877389,2877611..2877803,2877864..2878137); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184,FlyMine:FBpp0077368,modMine:FBpp0077368; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2L:complement(join(2877864..2878137,2877611..2877803,2877188..2877389)); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184,FlyMine:FBpp0077368,modMine:FBpp0077368; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2L:complement(join(2877864..2878137,2877611..2877803,2877188..2877389)); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184,FlyMine:FBpp0077368,modMine:FBpp0077368; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Peroxiredoxin 6005 OS=Drosophila melanogaster GN=Prx6005 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0077368 type=protein; loc=2L:complement(join(2877864..2878137,2877611..2877803,2877188..2877389)); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184,FlyMine:FBpp0077368,modMine:FBpp0077368; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2L:complement(join(2877864..2878137,2877611..2877803,2877188..2877389)); ID=FBpp0077368; name=Prx6005-PA; parent=FBgn0031479,FBtr0077684; dbxref=FlyBase:FBpp0077368,FlyBase_Annotation_IDs:CG3083-PA,GB_protein:AAF51184.1,REFSEQ:NP_523463,GB_protein:AAF51184,UniProt/TrEMBL:Q9VQI7,FlyMine:FBpp0077368,modMine:FBpp0077368; MD5=73f5cb7a285e3d1da07a14607d845843; length=222; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 222 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDA]
    Biological Process: cell redox homeostasis [ISS]
    hydrogen peroxide catabolic process [IDA]
    Molecular Function: peroxidase activity [NAS]
    glutathione peroxidase activity [ISS]
    antioxidant activity [ISS][NAS]
    thioredoxin peroxidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGKALNIGD QFPNFTAETS EGRIDFYDWM QDSWAILFSH PADFTPVCTT ELSRVAALIP  60
   61 EFQKRGVKPI ALSCDTVESH KGWIEDIKSF GKLSSFDYPI IADDKRELAL KFNMLDKDEI 120
  121 NAEGIPLTCR AVFVVDDKKK LRLSILYPAT TGRNFDEILR VIDSLQLTQT KSVATPADWK 180
  181 QGGKCMVLPT VKAEDVPKLF PDGIETIELP SGKSYLRITP QP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..222] PSI-BLAST 58.221849 HorF6 peroxidase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • selenium binding
    		•  2.92496040718744 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.30799114442278 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • transferase activity
    		•  1.26687471229876 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  0.23291471505999 bayes_pls_golite062009
  • copper ion binding
    		•  0.178842772364502 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.16328723676608 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0434052164026002 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle