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Protein Overview: spen-PA

General Information:
Name(s) found: spen-PA / FBpp0077781 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene split ends is referred to in FlyBase by the symbol Dmel\spen (CG18497, FBgn0016977). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:159034..203251. It has the cytological map location 21B3-21B4. There is experimental evidence that it has the molecular function</span>: transcription regulator activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of biological process; cellular component movement; organ morphogenesis; gliogenesis; neuroblast fate commitment; segment specification; regulation of metabolic process; organ development; cell communication; cell morphogenesis. 94 alleles are reported. The phenotypes of these alleles are annotated with 27 unique terms, many of which group under: organ system; nervous system; cephalopharyngeal skeleton; peripheral nervous system; multi-cell-component structure; cuticle; external compound sense organ; embryonic nervous system; pharyngeal sclerite; embryonic glial cell; abdominal segmental nerve; thoracic segment; embryonic thorax; commissure. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 5560 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: bristle morphogenesis [IMP]
    epidermal growth factor receptor signaling pathway [IMP]
    establishment or maintenance of cell polarity [IMP]
    neuroblast fate determination [IMP]
    axon guidance [IMP]
    Wnt receptor signaling pathway [IMP]
    peripheral nervous system development [IMP]
    imaginal disc-derived wing vein specification [IMP]
    regulation of transcription [IEA][IMP]
    glial cell fate determination [IMP]
    segment specification [IMP]
    glial cell migration [IMP]
    Molecular Function: nucleic acid binding [IEA]
    nucleotide binding [IEA]
    transcription regulator activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRCRNMVRD NSRNICFGKL AETTTTQQQQ QQQQFVVDSS TIINNNNNNN NNNNNQKLKR  60
   61 STEEPPTNSF ERNYYDRTTS RLVTQYQANN STSLANSNSS PSSVSASASV FATAAGGSSE 120
  121 RSRNRDRPYR NGSASVQGGG INSSNTTTTT AACTAGGSGS GAIGTGTGGL VGSGPGGVPQ 180
  181 ALGDRSSTQN IHQNHQSARV APPQSWYEAA TAATTAQLKS SGGSGNAGAS AAVGFTMSSS 240
  241 PINHHPHQHP HLQNPQHPHY TSSPVVGAGS CPSAAQGQPQ IQSQSQTTAV HRSVAYAGSA 300
  301 ADDLLNTATS RNMLLHSSKL NKLLKGAGAT GSGGERSGSE SPGRAGGATP LTTTSTITNN 360
  361 SFSSNSLNNT ITTATPTMPT IASGAAGSVG LGSGAEAGVC SNSGTASGDI LNVAAVLAAA 420
  421 VDNGVPTHPI RTRHNLHGRS TTSSSRSHSR SPSSYSSSHS SSSSSHSSSH SHASSPVQSS 480
  481 GNCAMAEGRS SRTVNSVTVT SNSSNPSGTA VTVSSAGVGG GCGSSSSSSS SSSSSGSSCL 540
  541 TANPVVHSED NRPLAIRVRN LPARSSDTSL KDGLFHEYKK HGKVTWVKVV GQNSERYALV 600
  601 CFKKPDDVEK ALEVSHDKHF FGCKIEVEPY QGYDVEDNEF RPYEAELDEY HPKSTRTLFI 660
  661 GNLEKDITAG ELRSHFEAFG EIIEIDIKKQ GLNAYAFCQY SDIVSVVKAM RKMDGEHLGS 720
  721 NRIKLGFGKS MPTNCVWIDG VDEKVSESFL QSQFTRFGAV TKVSIDRNRQ LALVLYDQVQ 780
  781 NAQAAVKDMR GTILRRKKLQ VDFASRECQD AFYDKQEKQQ QQSSGSNPRF SRYESSASSL 840
  841 QSRSRASSFS RHQNNSNDDC SPINTPGGAS SGISSASNLI NQSTSINISN IGTNACSAMP 900
  901 APSLASAVVS CNVNASGTVP ASTSMPSGVS SSSSSLPMSP AALAQRHRMV RNARQTVDCD 960
  961 FNEVGRLRFR SSEEVSGGAG NSTQFEDVRC DSPVTARQGS AVNCFTGPTA AVGESIDGTL1020
 1021 NNNQITGGAE GFTGSGGSIL SRRRCGKTPK DLHPVHNQRI QLAEQVEECP SSGDEGVVSP1080
 1081 RKRIKMDYHH HHHHSNASGV ESTGEHSSIN KPSPLLLSNC DVIHDPLNRK SEIRRVSETP1140
 1141 SGSPSIKFPG HLPSAPQSLM LSCRRPSIDV GALSALSSSS AFRHGIVGAS SMDQQHMMNA1200
 1201 SAAAKRRRVT TTMQQPSSSS TTNSSSGSGL GGISSLTPAD EYHHHVSRGR GHQLHSHHSH1260
 1261 EASGGESADG SRPGTPLCDE RPEVLPTEPR RLPPPRERVR ERTRDVMWLP LPKFGVLFFQ1320
 1321 QQQSRSSGGG GAGNSYLQQQ LGGGSTGGLG CIGAASSSAC SLNNSSLNAS QGMGSCSGST1380
 1381 FLPSPSSRYW RSSSHHQNQQ NNHQQQSQQL HGSSSSNTCL MASPARPRSL SSNSSDSDVP1440
 1441 GQNAGGSPSL DERLRNFEEN YERWSGGSSR EHISGHTPSS ATPSWQLSMH MNLSTGLNSH1500
 1501 QTSSASGNSN SSSGTVSSSA SNSRHKFLDI DELQPSDIVK SVLAKKSVFD DDFQRLNKNQ1560
 1561 WYDPSSSDFA LGSSSNIVTG SSLVANVSRH PGGPCSGNTS PALPNLAATK ATPIIGNCSG1620
 1621 GLGNSTGSKS AGLLQRLSSL SPMNSPQASM SPYNSPSPSP SVGGVTACLG QLTKPAAPGT1680
 1681 ASAGLSGGTA ASSSSPAANS GPTKGLQYPF PSHPPLPNTA APPPAVQPAP PPLPEMGKQS1740
 1741 RLTGQSSGNN LTKSLSVPDG PQSSPARVQL QKSASVPGST NVGAPSSLSL DSTTASVETS1800
 1801 ASISSSTSNG NSSLTSAAIH VQKPQQSTFV EEEHTKKSGT STSQSSSSSS KKISSTHDKL1860
 1861 HSKHNNRSES DKKIKKSDKN ASSSDKRKNS STSQSSKSAT PRIEDDSSEA DDTADKAEKN1920
 1921 QRHEKEKKER QEKREKDLRK QVEREEKDRK AQQEEREKED RKAKEEEKER EREKKAQEDR1980
 1981 EKKEREEREL REKEQRDKEQ KEKEIREKDL REKEQRERDN REKELRDKDL REKEMREKEQ2040
 2041 REKELHREKD QREREHREKE QSRRAMDVEQ EGRGGRMREL SSYQKSKMDI AGEASSLTAI2100
 2101 DCQHNKENAM DTIAQGTPGA SPSTPSDNTP KERSRKLSRN SPVRLHKRRL SSQESNHSAG2160
 2161 GGGSCGGSSH QIHHEDYVKR IRMENSQNIS VHSSNQRLND RRDSKEHKSS SFKEDKNSSS2220
 2221 HISRPHGCGG SSASSSKHHH RRDKHHQKGS ASSIETNSSI EVVVDPISQT KHNLNTSEEE2280
 2281 LQSHQPKREK EREHFSSHAN SSSSRHKSKR DHHHHREKKR HSVAESTNTD EEHTPQQHNP2340
 2341 HRRISAAGSG SAGELSSAAT NTSSGKLHHQ HHRRSVERKS SRGSDEGHHS SSKSLRAKLM2400
 2401 MLSSADSDDT DDASKKHSIF DIPDDCPNVS MYDKVKARSC KNMQRQAEEK KIKAKFSQLK2460
 2461 QSRAKKKRST SYDGDSDTEF EDRQHRNSGS SSFHGRYPGL SSSDDDDDEE THQRRISSDS2520
 2521 DAEHGGQDNQ GASTLADANR VRQMQQNLRR LCDGDDSSED EIRRNVMKHS HFGKRNSNST2580
 2581 RIASDSESQS QPAPDLTIKQ EHPIAPAQEI KREQLSDEEQ KFKSRHDSNS SIEERKLKTE2640
 2641 REIKTELGDF YNSSEYTYTG KLKEYSPETR KKHKKSKRRL KSSSTADTSA AQTPLVMTPL2700
 2701 TPSIFDVHSS SECKTKFDNF DDLKTECSSI PLEISAGERR KHKERKEKKR EKLRNMTEAT2760
 2761 VPNSPTTNDT SSEKLSKEER HRLKKSKKSK SMDNSCNTKI YNSSGAHPST SPSLPATPTS2820
 2821 APSTAQTSKR GEDKMEFIFG IISDEEESQF PEQAETNKDI IPSSVSTTGP IVSAALQTYK2880
 2881 QEPSTPNSKN EEAHIQLTVH EPEQQQQLER SRLSGGSSSS SHADRERHRR EKREKKRREK2940
 2941 SQREQQNQIH QKSSKVETKV DDDNSVDMDE AGRALEAQLM SDFDTKPISE EATPSTAATY3000
 3001 RSDMTDVFRF SDNEDNNSVD MTKQGVKSEQ QEQHKSKDKK KKKKRSKEEK QEKLLQQQRR3060
 3061 ESLPNVASTS SAPPTPGKLT VNVQAASKHA DLQLDAKHIS SPPVCKPSPS LPCLIGDDDD3120
 3121 DALHTPKAKP TTPSSRGNDG LTPSREKPRL ISPIPKTPTI ANSSTLSTQS AETPVSSGTV3180
 3181 ISSSALATTP TSSTAAGVSA APGLDNSPTS ASAQCKKKES FIPGFDGQLD DRISESAVQS3240
 3241 ISAEFNSTSL LDNIADEPKI PVASPPRATK PLDKLEESKS RVTISQEETE SAVSALLGES3300
 3301 FGTSSTTDYS LDGMDEMSSV NELETPTLVI AEPDEEAALA AKAIETAGEP ASILEEPEME3360
 3361 PEREAEPDPD PEAEIESEPV VEVLDPEELN KAVQSLKHED MMDIKADTPQ SERDLQIDTD3420
 3421 TEENPDEADS SGPSLKIDET VQSSSSPEKS ISNNSPTPRE TANIDIPNVE SQPKLSNEST3480
 3481 PQPSVITKLP FLDTPKTVPA GLPPSPVKIE PPTISKLQQP LVQPVQTVLP APHSTGSGIS3540
 3541 ANSVINLDLS NVISSCSNTS AASATASASA SISFGSPTAS QNAMPQASTP KQGPITPQQA3600
 3601 IRTQSLIMQP PTISIPEQTP HFAVPQMVLS PQSHHPQQPG TYMVGIRAPS PHSPLHSPGR3660
 3661 GVAQSRLVGQ LSPVGRPMVS QPSPQQQVQQ TQQQHALITS PQSSNISPLA SPTTRVLSSS3720
 3721 NSPTTSKVNS YQPRNQQVPQ QPSPKSVAEV QTTPQLMTIP LQKMTPIQVP HHPTIISKVV3780
 3781 TVQPQQATQS QVASSPPLGS LPPHKNVHLN AHQNQQQPQV IAKMTAHQHQ QHMQQFMHQQ3840
 3841 MIQRQQHMQQ QQLHGQSQQI TSAPQHQMHQ QHQAQQQQQH HNQQHLNQQL HAQQHPTQKQ3900
 3901 HQAQQQFNQQ IQQHQSQQQH QVQQQNQAQQ QHLSQQQHQS QQQLNQQHQA QQQQLQQIQK3960
 3961 LQQMHGPQQQ QKSPQGVGHL GGSTSIFASQ QHNSQLPARG VPQQQHPQQL SHSSPCKPNT4020
 4021 LVSVNQGVQP PAILTRVGSH SQPNQQQQLP HQQSSSGHPH QKQLSSPGAN LPLQTPLNVI4080
 4081 QNTPKIIVQQ HIVAQNQVPP PQTQGNAIHY PQNQGKDSTP PGHVEPTPAM SAQKTSESVS4140
 4141 VIRTPTPTTG LAVISANTVG SLLTEENLIK ISQPKQDELI EQDSKEVDSD YWSAKEVNID4200
 4201 SVIKKLDTPL ASKDAKRAVE MQAIAPAPIP NPQPGNQSMA QETALPTTSM SVNNSNDHDT4260
 4261 EDETETRQLP PAKPPIPTVG RPPGRGGSAK RGRQPRGAKK VGGFPLNSVT AAPPGVDSLV4320
 4321 VQPGDNGVQT RLRKPVTAPV TRGRKGRPPR NLLLQQQQLQ QQQLDIQRKG MEMVTSATSS4380
 4381 TPLPTPIPTS SVLTAAEKKA RNQALTQAQE QNQVASQVGT GQDIYEFHED GGEEPKPKTI4440
 4441 SSVAPSAEDQ RPRLILTINK TQPSIKNISE MEQTIQQQQQ QQSEVISNTD PIGGDNSESC4500
 4501 NTRKSRRLQE KEDRSTVDDI IEDVVRNTNT PTGTGPHLPK GAQTPPRRSG RNAQAKKTDA4560
 4561 VQIINAVGRP RRSKDRKTIG EQTANLIEEV TASNATVAAS HLAPPEGAGV ESHVPQLDAK4620
 4621 EVEPVSVVTP ISTPAPVSVA APVTVPVPAM VPVKPTMPQH PKKKAIAAAE IESYQAINSS4680
 4681 IPSGGLPMHQ TAAPATQKIT GGVADAVSKA LVDPVTGVIT AGMPQGKEGN LPAATAAAPA4740
 4741 NSSNEDGQAA PPPQLQHQQQ QQHPQQPPQQ QANLQINTTL IPSGLPNPIT ALGKSVQLET4800
 4801 SAAALLNKPV SVLVKGNASQ VIQQQQPQIV APAKQPIILQ QNPLPTVLHH AQHTTVRPPQ4860
 4861 PLKAHVLNRE KNIQQQLTPT KQAVAQPPQH APHSGHMLLT DTAGNQQLVQ PQIIARHLQQ4920
 4921 QQHLQVNVPP PTAHSPHSPR IPSQQQQLGP GASISPQQQQ PQTVVIKQAA SAAQPQILHV4980
 4981 VSSKASVVPQ PQQQQLPPTS STGPHLQLAK PNYSYAPTVL TPTLPAVQQQ QQQHLYKQNN5040
 5041 QQKGAQIQMP PHGIIMPTHP GMLLQQKLPA HLQPQQHQLN PSPPPGKPNP VLHGLQSGQI5100
 5101 MPGSVGSPPP VSAAVLKTAQ QQVNSVVPVA GIRTAIPNIS PQSQPRVSPL VLPPGISGVP5160
 5161 PFDASLHDLG AYVSGRRTQS PPPAHQQASP ITPNDSTYRG VTASRDFMLY QHHLMRGGDY5220
 5221 DDKMGSSPPL ELRRPGSGPP RTIAVPHSLQ SPQDRTAADS PQMAQVYVHN TRIPPAHFSE5280
 5281 IASRGLYDSG ALQLEPPPAH RPTATISVVV PQQMPAVSSG SPFIGRDGSV QPGSHHHPGK5340
 5341 AMDMQLDEMD RMSMIAAVVQ QQQEHLPPAL PAGMELASQQ APPAMAPPPG DSLVTLLQRY5400
 5401 PVMWQGLLAL KTDQAAVQMH FVHGNPNVAR ASLPSLVETN TPLLRIAQRM RLEQTQLEGV5460
 5461 AKKMQVDKEH CMLLALPCGR DHADVLQHSR NLQTGFITYL QQKMAAGIVN IPIPGSEQAA5520
 5521 YVVHIFPSCD FANENLERAA PDLKNRVAEL AHLLIVIATV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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