Protein Overview: Parp-PB

General Information:
Name(s) found:	Parp-PB / FBpp0112608 [FlyBase]
Description(s) found: Found 32 descriptions. SHOW ALL	The gene Poly-(ADP-ribose) polymerase is referred to in FlyBase by the symbol Dmel\Parp (CG40411, FBgn0010247). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3RHet:1935205..2026815. It has the cytological map location 81F. Based on sequence similarity, it is predicted to have molecular function</span>: NAD+ ADP-ribosyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: innate immune response; nucleolus organization; heat shock-mediated polytene chromosome puffing; protein amino acid ADP-ribosylation; positive regulation of antibacterial peptide biosynthetic process; maintenance of protein location in nucleus; regulation of RNA splicing. 16 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; compound cell cluster organ; nucleus; intracellular organelle part; organ system; intracellular membrane-bounded organelle; imaginal precursor; intracellular non-membrane-bounded organelle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	994 amino acids
Gene Ontology:
Cellular Component:	nucleus [NAS] polytene chromosome [IDA][TAS] polytene chromosome puff [IDA][TAS] nuclear euchromatin [IDA] chromosome [IDA] nucleolus [IDA][TAS]
Biological Process:	polytene chromosome puffing [TAS] protein amino acid ADP-ribosylation [IMP][NAS][TAS] nucleolus organization [IMP] chromosome organization [TAS] innate immune response [IMP] regulation of RNA splicing [IMP] rRNA transcription [TAS] heat shock-mediated polytene chromosome puffing [IEP][IMP] regulation of transcription, DNA-dependent [TAS] metamorphosis [TAS] positive regulation of antibacterial peptide biosynthetic process [IMP] maintenance of protein location in nucleus [IMP]
Molecular Function:	DNA binding [IEA] zinc ion binding [IEA] NAD or NADH binding [IEA] NAD+ ADP-ribosyltransferase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIELPYLAE YARTGRATCK GCKSTISKDT LRIAVMVQSA FHDAKVPNWF HKTCFFKNQR  60
   61 PSSVGDIQNI GNLRFADQKE LTDLVENIQE VISAQLGKKR SKAFNLALKD FGIEYAKSSR 120
  121 STCRGCEQKI NKDLVRLRKT VYDTEVGMKY GGQPLWHHLE CFAQLRSELG WFASGEDMPG 180
  181 FQSLADDDQA KVKNAIPPIK SEELPDTKRA KMELSDTNEE GEKKQRLKDQ NDAYFRFRDD 240
  241 IKNKMKKKDI DILLKFNNQQ PVTGDTEKLF DQTADLLTFG AIESCSECNS CQFIVNKSGY 300
  301 ICNGNHSEWT KCNKLLKEPT RSACIVPKEL KALYNFLNTV KEIPSTRIFN NFPPNKSTFS 360
  361 RSLLKTNKNN DVLVRPTIPR ISPPLYNLKF SIIGLKNQHK ELRKRIENLG GKFEVKISEN 420
  421 TIAIISTELE IQKKSTRMKF AEELGIHIVP IEFLDFVEAD TEGAIKYINS TCICSWGTDP 480
  481 KSRIPKETTK SLNSNSIYTK SMPVSRTFKV KDGLAVDPDS GLEDIAHVYV DSNNKYSVVL 540
  541 GLTDIQRNKN SYYKVQLLKA DKKEKYWIFR SWGRIGTNIG NSKLEEFDTS ESAKRNFKEI 600
  601 YADKTGNEYE QRDNFVKRTG RMYPIEIQYD DDQKLVKHES HFFTSKLEIS VQNLIKLIFD 660
  661 IDSMNKTLME FHIDMDKMPL GKLSAHQIQS AYRVVKEIYN VLECGSNTAK LIDATNRFYT 720
  721 LIPHNFGVQL PTLIETHQQI EDLRQMLDSL AEIEVAYSII KSEDVSDACN PLDNHYAQIK 780
  781 TQLVALDKNS EEFSILSQYV KNTHASTHKS YDLKIVDVFK VSRQGEARRF KPFKKLHNRK 840
  841 LLWHGSRLTN FVGILSHGLR IAPPEAPPTG YMFGKGIYFA DMVSKSANYC CTSQQNSTGL 900
  901 MLLSEVALGD MMECTSAKYI NKLSNNKHSC FGRGRTMPDP TKSYIRSDGV EIPYGETITD 960
  961 EHLKSSLLYN EYIVYDVAQV NIQYLFRMEF KYSY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: Parp-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: