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Protein Overview: p120ctn-PA

General Information:
Name(s) found: p120ctn-PA / FBpp0110406 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Adherens junction protein p120 is referred to in FlyBase by the symbol Dmel\p120ctn (CG17484, FBgn0260799). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:482798..496995. It has the cytological map location 41B1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: binding. There is experimental evidence that it is involved in the biological process</span>: adherens junction maintenance; cell adhesion; compound eye morphogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; stage 14 embryo; inter-ommatidial cell; embryonic leading edge cell. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 781 amino acids

    Gene Ontology:
    Cellular Component: adherens junction [IDA][IPI][ISS]
    centrosome [IDA]
    cytoplasm [IDA]
    Biological Process: compound eye morphogenesis [IGI][IMP]
    cell adhesion [IGI]
    adherens junction maintenance [IMP]
    Molecular Function: binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEARSLKHSL IGLNMNSTHI NMDLSLTHEP ANMQSQFGSF QNYDQFSAAG YSSTPLYITK  60
   61 PTGVGAITKV APHCSQNKIE TNSTDNSIPD IENHPLATTV RYVQAGQYED TSEYGVAGLT 120
  121 CGIDSEYTAE AVVPYCYTSD ANYTGIQNTT SSIKPFSGRP FNDNINGAEA VADSQCRTFK 180
  181 SSAEFKLPQF AMSSINTVPQ RLEEKDDYIE GSENDICSTM RWRDPNLSEV ISFLSNPSSA 240
  241 IKANAAAYLQ HLCYMDDPNK QRTRSLGGIP PLVRLLSYDS PEIHKNACGA LRNLSYGRQN 300
  301 DENKRGIKNA GGIAALVHLL CRSQETEVKE LVTGVLWNMS SCEDLKRSII DEALVAVVCS 360
  361 VIKPHSGWDA VCCGETCFST VFRNASGVLR NVSSAGEHAR GCLRNCEHLV ECLLYVVRTS 420
  421 IEKNNIGNKT VENCVCILRN LSYRCQEVDD PNYDKHPFIT PERVIPSSSK GENLGCFGTN 480
  481 KKKKEANNSD ALNEYNISAD YSKSSVTYNK LNKGYEQLWQ PEVVQYYLSL LQSCSNPETL 540
  541 EAAAGAIQNL SACYWQPSID IRATVRKEKG LPILVELLRM EVDRVVCAVA TALRNLAIDQ 600
  601 RNKELIGKYA MRDLVQKLPS GNVQHDQNTS DDTITAVLAT INEVIKKNPE FSRSLLDSGG 660
  661 IDRLMNITKR KEKYTSCVLK FASQVLYTMW QHNELRDVYK KNGWKEQDFV SKHFTAHNTP 720
  721 PSSPNNVNNT LNRPMASQGR TRYEDRTIQR GTSTLYSAND SSGAVMSNES AMLSEMVRKQ 780
  781 L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] PSI-BLAST 42.69897 Importin alpha
    2 View Details [184..626] PSI-BLAST 29.69897 Adaptin beta subunit N-terminal fragment
    3 View Details [627..696] PSI-BLAST 59.221849 Structure of the armadillo repeat domain of plakophilin 1
    4 View Details [697..781] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.99013774955562 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.83254788740042 bayes_pls_golite062009
  • protein binding
    		•  1.75981610748679 bayes_pls_golite062009
  • RPTP-like protein binding
    		•  1.38347756516661 bayes_pls_golite062009
  • cadherin binding
    		•  0.1400783779596 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle