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Protein Overview: FKB1B_RAT

General Information:
Name(s) found: FKB1B_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6225324|sp|P97534.3|FKB1B_RAT RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP1B; Short=PPIase FKBP1B; AltName: Full=FK506-binding protein 1B; Short=FKBP-1B; AltName: Full=Rotamase; AltName: Full=Immunophilin FKBP12.6; Short=12.6 kDa FKBP; Short= [NCBI NR]
  • gi|1843432|dbj|BAA13154.1| FK506-binding protein 12.6 [Rattus norvegicus] [NCBI NR]
  • gi|149050876|gb|EDM03049.1| FK506 binding protein 1b [Rattus norvegicus] [NCBI NR]
  • gi|12083613|ref|NP_073166.1| FK506 binding protein 1B, 12.6 kDa [Rattus norvegicus] [NCBI NR]
  • Peptidyl-prolyl cis-trans isomerase FKBP1B OS=Rattus norvegicus GN=Fkbp1b PE=1 SV=3 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None FK506 binding protein 1b [hmr_yeast5_DM3-1_pombe.fasta]
  • FK506 binding protein 1b; FK506 binding protein 1b (12.6 kDa) [HMR_022704-rand.fasta]
  • FK506 binding protein 1b [Rattus norvegicus]gi|1843432|dbj|BAA13154.1| FK506-binding protein 12.6 [Rattus norvegicus]gi|6225324|sp|P97534|FKBB_RAT FK506-binding protein 1B (Peptidyl-prolyl cis-trans isomerase) (PPiase) (Rotamase) (12.6 kDa FKBP) (FKBP-1 [nrdb_11152004_Chlamydomonas]
  • (NM_022675) FK506 binding protein 1b; FK506 binding protein 1b (12.6 kDa) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • FK506-binding protein 1B (Peptidyl-prolyl cis-trans isomerase 1B) (PPIase 1B) (Rotamase 1B) (Immunophilin FKBP12.6) (12.6 kDa FKBP) (FKBP-12.6) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • FK506 binding protein 1b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • FK506-binding protein 12.6 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 FK506 BINDING PROTEIN 1B [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • FK506 binding protein 1B, 12.6 kDa [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • FK506-binding protein 1B (Peptidyl-prolyl cis-trans isomerase 1B) (PPIase 1B) (Rotamase 1B) (12.6 kDa FKBP) (FKBP-12.6) (Immunophilin FKBP12.6) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Fkbp1b Peptidyl-prolyl cis-trans isomerase FKBP1B [rat-ipi-250309-contam.fasta]
  • Peptidyl-prolyl cis-trans isomerase FKBP1B OS=Rattus norvegicus GN=Fkbp1b [011711_HMR.fasta]
  • Peptidyl-prolyl cis-trans isomerase FKBP1B OS=Rattus norvegicus GN=Fkbp1b PE=2 SV=3 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 108 amino acids

    Gene Ontology:
    Cellular Component: calcium channel complex [UNKNOWN]
    microsome [IDA]
    sarcoplasmic reticulum membrane [UNKNOWN]
    Biological Process: response to organic substance [IEP]
    insulin secretion [UNKNOWN]
    response to vitamin E [IEP]
    response to hydrogen peroxide [IEP]
    protein folding [IEA]
    regulation of ryanodine-sensitive calcium-release channel activity [UNKNOWN]
    elevation of cytosolic calcium ion concentration [IDA]
    regulation of heart rate [UNKNOWN]
    response to redox state [UNKNOWN]
    response to glucose stimulus [UNKNOWN]
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [UNKNOWN]
    smooth muscle contraction [UNKNOWN]
    T cell proliferation [UNKNOWN]
    [NOT]regulation of calcium ion transport via store-operated calcium channel activity [UNKNOWN]
    release of sequestered calcium ion into cytosol [UNKNOWN]
    neuronal action potential propagation [UNKNOWN]
    negative regulation of protein phosphatase type 2B activity [UNKNOWN]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [UNKNOWN][IEA]
    protein binding [UNKNOWN][IDA]
    FK506 binding [UNKNOWN][IDA]
    receptor binding [UNKNOWN]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVEIETISP GDGRTFPKKG QICVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF  60
   61 EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 35.522879 ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle