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Protein Overview: NFL_RAT

General Information:
Name(s) found: NFL_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Neurofilament light polypeptide OS=Rattus norvegicus GN=Nefl PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 542 amino acids

    Gene Ontology:
    Cellular Component: cytosol [UNKNOWN]
    intermediate filament [UNKNOWN]
    TSC1-TSC2 complex [UNKNOWN][IEA]
    neurofilament [UNKNOWN][NAS]
    neuron projection [IDA]
    axon [UNKNOWN][IDA]
    Biological Process: response to organic substance [IEP]
    axon regeneration in the peripheral nervous system [UNKNOWN][IEA]
    anterograde axon cargo transport [UNKNOWN][IEA]
    neurofilament bundle assembly [UNKNOWN][IEA]
    locomotion [UNKNOWN][IEA]
    neurofilament cytoskeleton organization [UNKNOWN]
    neuron projection morphogenesis [UNKNOWN][IEA]
    microtubule cytoskeleton organization [UNKNOWN][IEA]
    response to toxin [IEP]
    response to peptide hormone stimulus [IEP]
    intermediate filament organization [UNKNOWN]
    response to stress [IEP]
    negative regulation of neuron apoptosis [UNKNOWN][IEA]
    protein polymerization [IDA]
    response to corticosterone stimulus [IEP]
    positive regulation of axonogenesis [UNKNOWN][IEA]
    intermediate filament bundle assembly [UNKNOWN]
    axon transport of mitochondrion [UNKNOWN][IEA]
    regulation of axon diameter [UNKNOWN][IEA]
    response to organic nitrogen [IEP]
    retrograde axon cargo transport [UNKNOWN][IEA]
    neuromuscular process controlling balance [UNKNOWN][IEA]
    Molecular Function: protein domain specific binding [IPI]
    identical protein binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IDA]
    protein C-terminus binding [UNKNOWN][IEA]
    phospholipase binding [IPI]
    structural constituent of cytoskeleton [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSFSYEPYF STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS LSVRRSYSSS  60
   61 SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR FASFIERVHE LEQQNKVLEA 120
  121 ELLVLRQKHS EPSRFRALYE QEIRDLRLAA EDATNEKQAL QGEREGLEET LRNLQARYEE 180
  181 EVLSREDAEG RLMEARKGAD EAALARAELE KRIDSLMDEI AFLKKVHEEE IAELQAQIQY 240
  241 AQISVEMDVS SKPDLSAALK DIRAQYEKLA AKNMQNAEEW FKSRFTVLTE SAAKNTDAVR 300
  301 AAKDEVSESR RLLKAKTLEI EACRGMNEAL EKQLQELEDK QNADISAMQD TINKLENELR 360
  361 STKSEMARYL KEYQDLLNVK MALDIEIAAY RKLLEGEETR LSFTSVGSIT SGYSQSSQVF 420
  421 GRSAYSGLQS SSYLMSARAF PAYYTSHVQE EQSEVEETIE ATKAEEAKDE PPSEGEAEEE 480
  481 EKEKEEGEEE EGAEEEEAAK DESEDAKEEE GGEGEEEDTK ESEEEEKKEE SAGEEQAAKK 540
  541 KD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle