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Protein Overview: PDE2A_RAT

General Information:
Name(s) found: PDE2A_RAT [Swiss-Prot]
Description(s) found:
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  • gi|706930|gb|AAA63683.1| cyclic GMP stimulated phosphodiesterase [NCBI NR]
  • gi|1705944|sp|Q01062.2|PDE2A_RAT RecName: Full=cGMP-dependent 3',5'-cyclic phosphodiesterase; AltName: Full=Cyclic GMP-stimulated phosphodiesterase; Short=CGS-PDE; Short=cGSPDE [NCBI NR]
  • gi|149068727|gb|EDM18279.1| phosphodiesterase 2A, cGMP-stimulated, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|13592021|ref|NP_112341.1| phosphodiesterase 2A isoform 2 [Rattus norvegicus] [NCBI NR]
  • pir||JC2486 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17), cGMP-stimulated - rat [NCBI NR]
  • cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Rattus norvegicus GN=Pde2a PE=1 SV=2 [Swiss-Prot]
  • (Q01062) cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-156434950;1-156434950 cGMP-dependent 3',5'-cyclic phosphodiesterase [hmr_yeast5_DM3-1_pombe.fasta]
  • phosphodiesterase 2A, cGMP-stimulated; cyclic GMP stimulated phosphodiesterase [HMR_022704-rand.fasta]
  • phosphodiesterase 2A, cGMP-stimulated [Rattus norvegicus]gi|1705944|sp|Q01062|CN2A_RAT cGMP-dependent 3',5'-cyclic phosphodiesterase (Cyclic GMP stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)gi|1083575|pir||JC2486 3',5'-cyclic-nucleotide phosphodieste [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform PDE2A3 of cGMP-dependent 3',5'-cyclic phosphodiesterase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031079) cyclic GMP stimulated phosphodiesterase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • cGMP-dependent 3',5'-cyclic phosphodiesterase (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phosphodiesterase 2A, cGMP-stimulated [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • phosphodiesterase 2A, cGMP-stimulated, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • cyclic GMP stimulated phosphodiesterase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SPLICE ISOFORM 1 OF CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • phosphodiesterase 2A, cGMP-stimulated isoform 2 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pde2a cGMP-dependent 3',5'-cyclic phosphodiesterase [rat-ipi-250309-contam.fasta]
  • Isoform PDE2A3 of cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Rattus norvegicus GN=Pde2a [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 928 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    membrane raft [IDA]
    Biological Process: signal transduction [IEA]
    cGMP catabolic process [IDA]
    cAMP catabolic process [IDA]
    Molecular Function: nucleotide binding [IEA]
    cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [IDA]
    protein binding [UNKNOWN][IPI]
    protein homodimerization activity [IDA]
    catalytic activity [IEA]
    metal ion binding [IEA]
    cAMP binding [IDA]
    cGMP binding [IDA]
    3',5'-cyclic-nucleotide phosphodiesterase activity [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLVLHHILI AVVQFLRRGQ QVFLKPDEPP PQPCADSLQD ALLSLGAVID IAGLRQAAKD  60
   61 ALSAVLPKVE TVYTYLVDGE SRLVCEDPPH ELPQEGKIRE AVISRKRLSC DGLGPSDLLG 120
  121 KPLARLVAPL APDTQVLVIP LLDKETGTVA AVILVHCGQL SDSEEQSLQV VEKHALVALQ 180
  181 RVQALQQRRP EAVQNTSADP SEDQKDEKGY TAHDRKILQL CGELYDLDAT SLQLKVLRYL 240
  241 QQETQATHCC LLLVSEDNLQ LSCKVIGEKV LGEEVSFPLT MGRLGQVVED KQCIQLKDLT 300
  301 SDDVQQLQNM LGCELRAMLC VPVISRATDQ VVALACAFNK LGGDFFTDED ERAIQHCFHY 360
  361 TGTVLTSTLA FQKEQKLKCE CQALLQVAKN LFTHLDDVSV LLQEIITEAR NLSNAEICSV 420
  421 FLLDQNELVA KVFDGGVVDD ESYEIRIPAD QGIAGHVATT GQILNIPDAY AHPLFYRGVD 480
  481 DSTGFRTRNI LCFPIKNENQ EVIGVAELVN KINGPWFSKF DEDLATAFSI YCGISIAHSL 540
  541 LYKKVNEAQY RSHLANEMMM YHMKVSDDEY TKLLHDGIQP VAAIDSNFAN FTYTPRSLPE 600
  601 DDTSMAILSM LQDMNFINNY KIDCPTLARF CLMVKKGYRD PPYHNWMHAF SVSHFCYLLY 660
  661 KNLELSNYLE DIEIFALFIS CMCHDLDHRG TNNSFQVASK SVLAALYSSE GSVMERHHFA 720
  721 QAIAILNTHG CNIFDHFSRK DYQRMLDLMR DIILATDLAH HLRIFKDLQK MAEVGYDRNN 780
  781 KQHHRLLLCL LMTSCDLSDQ TKGWKTTRKI AELIYKEFFS QGDLEKAMGN RPMEMMDREK 840
  841 AYIPELQISF MEHIAMPIYK LLQDLFPKAA ELYERVASNR EHWTKVSHKF TIRGLPSNNS 900
  901 LDFLDEEYEV PDLDVTRAPV NGCCSLEG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle