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Protein Overview: AKA12_RAT

General Information:
Name(s) found: AKA12_RAT [Swiss-Prot]
Description(s) found:
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  • gi|81862297|sp|Q5QD51.1|AKA12_RAT RecName: Full=A-kinase anchor protein 12 [NCBI NR]
  • gi|75905809|ref|NP_476444.2| A kinase anchor protein 12 isoform alpha [Rattus norvegicus] [NCBI NR]
  • gi|56199805|gb|AAV84358.1| A kinase anchoring protein 12 alpha [Rattus norvegicus] [NCBI NR]
  • gi|149038541|gb|EDL92871.1| A kinase (PRKA) anchor protein (gravin) 12, isoform CRA_c [Rattus norvegicus] [NCBI NR]
  • A-kinase anchor protein 12 OS=Rattus norvegicus GN=Akap12 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-39619690 [hmr_yeast5_DM3-1_pombe.fasta]
  • Tax_Id=10116 A kinase anchor protein 12 isoform alpha [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 A kinase anchoring protein 12 alpha [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • A kinase anchor protein 12 isoform alpha [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • A-kinase anchor protein 12 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • A kinase (PRKA) anchor protein (gravin) 12, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • A kinase anchoring protein 12 alpha [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 181KDA PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Akap12 Isoform 1 of A-kinase anchor protein 12 [rat-ipi-250309-contam.fasta]
  • Isoform 1 of A-kinase anchor protein 12 OS=Rattus norvegicus GN=Akap12 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 1687 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    cytoskeleton [IEA]
    cytoplasm [IEA]
    plasma membrane [IEA]
    Biological Process: protein targeting [IEA]
    positive regulation of protein kinase A signaling cascade [UNKNOWN]
    signal transduction [IDA]
    positive regulation of cAMP biosynthetic process [UNKNOWN]
    Molecular Function: protein binding [IEA]
    adenylate cyclase binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAGSSTEQR SPEQPAGSDT PSELVLSGHG PAAEASGAAG DPADADPATK LPQKNGQLST  60
   61 VNGVAEQGDV HVQEENQEGQ EEEVVDEDVG QRESEDVREK DRVEEMAANS TAVEDITKDG 120
  121 QEETSEIIEQ IPASESNVEE MVQPAESQAN DVGFKKVFKF VGFKFTVKKD KNEKSDTVQL 180
  181 LTVKKDEGEG AEASVGAGDH QEPSVETAVG ESASKESELK QSTEKQEGTL KQEQSSTEIP 240
  241 LQAESDQAAE EEAKDEGEEK QEKEPTKSPE SPSSPVSSET TSSFKKFFTH GWAGWRKKTS 300
  301 FKKSKEDDLE TAEKRKEQEA EKVDEEEKEK TEPASEEQEP AEDTDQARLS ADYEKVELPL 360
  361 EDQVGDLEAS SEEKCAPLAT EVFDEKMEAH QEVVAEVHVS TVEKTEEEQG GGGEAEGGVV 420
  421 VEGTGESLPP EKLAEPQEVP QEAEPAEELM KSREMCVSGG DHTQLTDLSP EEKTLPKHPE 480
  481 GIVSEVEMLS SQERIKVQGS PLKKLFSSSG LKKLSGKKQK GKRGGGGDEE PGEYQHIHTE 540
  541 SPESADEQKG ESSASSPEEP EETTCLEKGP LEAPQDGEAE EGTTSDGEKK REGITPWASF 600
  601 KKMVTPKKRV RRPSESDKEE ELEKVKSATL SSTDSTVSEM QDEVKTVGEE QKPEEPKRRV 660
  661 DTSVSWEALI CVGSSKKRAR KASSSDDEGG PRTLGGDSHR AEEASKDKEA GTDAVPASTQ 720
  721 EQDQAQGSSS PEPAGSPSEG EGVSTWESFK RLVTPRKKSK SKLEEKAEDS SVEQLSTEIE 780
  781 PSREESWVSI KKFIPGRRKK RADGKQEQAT VEDSGPVEIN EDDPDVPAVV PLSEYDAVER 840
  841 EKMEAQGNAE LPQLLGAVYV SEELSKTLVH TVSVAVIDGT RAVTSVEERS PSWISASVTE 900
  901 PLEHTAGEAM PPVEEVTEKD IIAEETPVLT QTLPEGKDAH DDMVTSEVDF TSEAVTATET 960
  961 SEALRTEEVT EASGAEETTD MVSAVSQLTD SPDTTEEATP VQEVEGGVLD TEEEERQTQA1020
 1021 ILQAVADKVK EESQVPATQT VQRTGSKALE KVEEVEEDSE VLASEKEKDV MPKGPVQEAG1080
 1081 AEHLAQGSET GQATPESLEV PEVTADVDHV ATCQVIKLQQ LMEQAVAPES SETLTDSETN1140
 1141 GSTPLADSDT ADGTQQDETI DSQDSKATAA VRQSQVTEEE AATAQKEEPS TLPNNVPAQE1200
 1201 EHGEEPGRDV LEPTQQELAA AAVPVLAKTE VGQEGEVDWL DGEKVKEEQE VFVHSGPNSQ1260
 1261 KAADVTYDSE VMGVAGCQEK ESTEVQSLSL EEGEMETDVE KEKRETKPEQ VSEEGEQETA1320
 1321 APEHEGTYGK PVLTLDMPSS ERGKALGSLG GSPSLPDQDK AGCIEVQVQS LDTTVTQTAE1380
 1381 AVEKVIETVV ISETGESPEC VGAHLLPAEK SSATGGHWTL QHAEDTVPLG PESQAESIPI1440
 1441 IVTPAPESTL HPDLQGEISA SQRERSEEED KPDAGPDADG KESTAIEKVL KAEPEILELE1500
 1501 SKSNKIVLNV IQTAVDQFAR TETAPETHAY DSQTQVPAMQ ADSQGAQQML DKNESCQDET1560
 1561 PSAAAQRGLA SPDRSGGMGS ASEMLAALAV ESAGVKVSIE KLPPQPKDQK EHAADGPQLQ1620
 1621 SLAQAEASAS GNLTKESPDT NGPKLTEEGD APKVEVQEEE MSTKSVKENK AQAEEDLQEP1680
 1681 KGDLAES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle