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Protein Overview: DAB1_RAT

General Information:
Name(s) found: DAB1_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Disabled homolog 1 OS=Rattus norvegicus GN=Dab1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 555 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    postsynaptic density [IDA]
    perinuclear region of cytoplasm [UNKNOWN]
    brush border [IDA]
    apical part of cell [IDA]
    cytosol [IDA]
    neuronal cell body [IDA]
    neuron projection [IDA]
    Biological Process: midgut development [IEP]
    small GTPase mediated signal transduction [UNKNOWN]
    multicellular organismal development [IEA]
    cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration [UNKNOWN]
    negative regulation of cell adhesion [UNKNOWN]
    nervous system development [IEA]
    cerebellum structural organization [UNKNOWN]
    cerebral cortex radially oriented cell migration [UNKNOWN][IMP]
    radial glia guided migration of Purkinje cell [UNKNOWN]
    brain development [IEP]
    cerebral cortex development [IEP]
    cerebral cortex cell migration [UNKNOWN]
    neuron migration [UNKNOWN][IDA]
    positive regulation of protein kinase activity [UNKNOWN]
    response to drug [IEP]
    cell differentiation [IEA]
    Molecular Function: phosphoinositide 3-kinase binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL  60
   61 CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI 120
  121 TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC 180
  181 EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV 240
  241 SAVTQLELFG DMSTPPDITS PPTPATPGDA FLPAPSQTLP GSADVFGSMS FGTAAVPSGY 300
  301 VAMGAVLPSF WGQQPLVQQQ IAMGAQPPVA QVIPGAQPIA WGQPGLFPAT QQPWPTVAGQ 360
  361 FPPAAFMPTQ TVMPLPAAMF QGPLTPLATV PGTNDSARSS PQSDKPRQKM GKEMFKDFQM 420
  421 AQPPPVPSRK PDQPSLTCTS EAFSSYFNKV GVAQDTDDCD DFDISQLNLT PVTSTTPSTN 480
  481 SPPTPAPRQS SPSKSSASHV SDPTADDIFE EGFESPSKSE EQEAPDGSQA SSTSDPFGEP 540
  541 SGEPSGDNIS PQDGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle