Protein Overview: TPH2_RAT

General Information:
Name(s) found:	TPH2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|30580595\|sp\|Q8CGU9.1\|TPH2_RAT RecName: Full=Tryptophan 5-hydroxylase 2; AltName: Full=Tryptophan 5-monooxygenase 2; AltName: Full=Neuronal tryptophan hydroxylase [NCBI NR] gi\|27753970\|ref\|NP_776211.1\| tryptophan hydroxylase 2 [Rattus norvegicus] [NCBI NR] gi\|27497161\|gb\|AAM28947.1\| neuronal tryptophan hydroxylase [Rattus norvegicus] [NCBI NR] gi\|149066963\|gb\|EDM16696.1\| tryptophan hydroxylase 2, isoform CRA_b [Rattus norvegicus] [NCBI NR] Tryptophan 5-hydroxylase 2 OS=Rattus norvegicus GN=Tph2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):7-45170319 Tryptophan 5-hydroxylase 2 [hmr_yeast5_DM3-1_pombe.fasta] tryptophan hydroxylase 2; neuronal tryptophan hydroxylase [HMR_022704-rand.fasta] tryptophan hydroxylase 2 [Rattus norvegicus]gi\|27497161\|gb\|AAM28947.1\| neuronal tryptophan hydroxylase [Rattus norvegicus]gi\|30580595\|sp\|Q8CGU9\|TPH2_RAT Tryptophan 5-hydroxylase 2 (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Tryptophan 5-hydroxylase 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tryptophan 5-hydroxylase 2 (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] tryptophan hydroxylase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] tryptophan hydroxylase 2, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] neuronal tryptophan hydroxylase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Tph2 Tryptophan 5-hydroxylase 2 [rat-ipi-250309-contam.fasta] Tryptophan 5-hydroxylase 2 OS=Rattus norvegicus GN=Tph2 [011711_HMR.fasta] Tryptophan 5-hydroxylase 2 OS=Rattus norvegicus GN=Tph2 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	485 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	serotonin biosynthetic process [IEA] cellular response to lithium ion [IEP] aromatic amino acid family metabolic process [IEA] response to estrogen stimulus [IEP] response to calcium ion [IEP] response to glucocorticoid stimulus [IEP] oxidation reduction [IEA] response to activity [IEP] circadian rhythm [IEP] response to nutrient levels [IEP] response to stress [IEP]
Molecular Function:	iron ion binding [IEA] metal ion binding [IEA] amino acid binding [IEA] molecular_function [ND] tryptophan 5-monooxygenase activity [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPAMMMFSS KYWARRGLSL DSAVPEEHQI LGGLTQNKAT ASKSEDKRSG KDTSESSKTA  60
   61 VVFSLKNEVG GLVRALRLFQ EKHVNMLHIE SRRSRRRSSE VEIFVDCECG KTEFNELIQL 120
  121 LKFQTTIVTL NPPDNIWTEE EELEDVPWFP RKISELDRCS HRVLMYGTEL DADHPGFKDN 180
  181 VYRQRRKYFV DVAMGYKYGQ PIPRVEYTEE ETKTWGVVFR ELSKLYPTHA CREYLKNFPL 240
  241 LTKYCGYRED NVPQLEDVSM FLKERSGFTV RPVAGYLSPR DFLAGLAYRV FHCTQYVRHG 300
  301 SDPLYTPEPD TCHELLGHVP LLADPKFAQF SQEIGLASLG ASDEDVQKLA TCYFFTIEFG 360
  361 LCKQEGQLRA YGAGLLSSIG ELKHALSDKA CVKAFDPKTT CLQECLITTF QDAYFVSESF 420
  421 EEAKEKMRDF AKSITRPFSV YFNPYTQSIE ILKDTRSIEN VVQDLRSDLN TVCDALNKMN 480
  481 QYLGI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: TPH2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: