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Protein Overview: GSH0_RAT

General Information:
Name(s) found: GSH0_RAT [Swiss-Prot]
Description(s) found:
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  • gi|8393446|ref|NP_059001.1| glutamate cysteine ligase, modifier subunit [Rattus norvegicus] [NCBI NR]
  • gi|50927319|gb|AAH78867.1| Glutamate cysteine ligase, modifier subunit [Rattus norvegicus] [NCBI NR]
  • pir||A48019 gamma-glutamylcysteine synthetase light chain - rat [NCBI NR]
  • gi|410309|gb|AAA41543.1| gamma-glutamylcysteine synthetase [NCBI NR]
  • gi|149025852|gb|EDL82095.1| glutamate cysteine ligase, modifier subunit [Rattus norvegicus] [NCBI NR]
  • gi|1346189|sp|P48508.1|GSH0_RAT RecName: Full=Glutamate--cysteine ligase regulatory subunit; AltName: Full=Gamma-glutamylcysteine synthetase regulatory subunit; AltName: Full=Gamma-ECS regulatory subunit; AltName: Full=GCS light chain; AltName: Full=Gluta [NCBI NR]
  • Glutamate--cysteine ligase regulatory subunit OS=Rattus norvegicus GN=Gclm PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):2-212944408 Glutamate--cysteine ligase regulatory subunit [hmr_yeast5_DM3-1_pombe.fasta]
  • glutamate cysteine ligase, modifier subunit; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase , modifier subunit; glutamate cysteine ligase (gamma-glutamylcysteine synthetase) regulatory; glutamate cyste [HMR_022704-rand.fasta]
  • glutamate cysteine ligase, modifier subunit; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase (gamma-glutamylcysteine synthetase) regulatory; glutamate cysteine ligase modifier subunit; glutamate cystei [071204_hmrz_cont.fasta]
  • glutamate cysteine ligase, modifier subunit [Rattus norvegicus]gi|50927319|gb|AAH78867.1| Glutamate cysteine ligase, modifier subunit [Rattus norvegicus]gi|1346189|sp|P48508|GSH0_RAT Glutamate--cysteine ligase regulatory subunit (Gamma-glutamylcysteine [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Glutamate--cysteine ligase regulatory subunit [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_017305) Glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate-cysteine ligase , modifier subunit [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Glutamate--cysteine ligase regulatory subunit (Gamma-glutamylcysteine synthetase regulatory subunit) (Gamma-ECS regulatory subunit) (GCS light chain) (Glutamate--cysteine ligase modifier subunit) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • glutamate cysteine ligase, modifier subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Glutamate cysteine ligase, modifier subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • gamma-glutamylcysteine synthetase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Glutamate--cysteine ligase regulatory subunit (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS light chain) (Glutamate--cysteine ligase modifier subunit) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Gclm Glutamate--cysteine ligase regulatory subunit [rat-ipi-250309-contam.fasta]
  • Glutamate--cysteine ligase regulatory subunit OS=Rattus norvegicus GN=Gclm [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 274 amino acids

    Gene Ontology:
    Cellular Component: glutamate-cysteine ligase complex [UNKNOWN][IDA]
    soluble fraction [UNKNOWN][ISS]
    Biological Process: glutathione biosynthetic process [UNKNOWN][IMP][ISS]
    cysteine metabolic process [UNKNOWN][IEA]
    negative regulation of neuron apoptosis [IMP]
    response to oxidative stress [UNKNOWN][IMP][ISS]
    glutamate metabolic process [UNKNOWN][ISS]
    regulation of blood vessel size [UNKNOWN][ISS]
    glutathione metabolic process [UNKNOWN]
    response to drug [UNKNOWN][ISS]
    negative regulation of apoptosis [UNKNOWN]
    positive regulation of glutamate-cysteine ligase activity [UNKNOWN][IDA]
    response to nitrosative stress [IMP]
    oxidation reduction [IEA]
    regulation of mitochondrial depolarization [UNKNOWN][IEA]
    Molecular Function: protein binding [UNKNOWN][IEA]
    oxidoreductase activity [IEA]
    protein heterodimerization activity [UNKNOWN][IDA]
    glutamate-cysteine ligase activity [UNKNOWN][IDA][IMP][ISS]
    glutamate-cysteine ligase catalytic subunit binding [UNKNOWN][IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTDSRAAGA LLARASTLHL QTGNLLNWGR LRKKCPSTHS EELRDCIQKT LNEWSSQISP  60
   61 DLVREFPDVL ECTMSHAVEK INPDEREEMK VSAKLFIVGS NSSSSTRNAV DMACSVLGVA 120
  121 QLDSVIMASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ 180
  181 VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIEAQ 240
  241 EWVPLWLLRY SVIVKSRGII KSKGYILQAK RKGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.54

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle