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Protein Overview: ATP7B_RAT

General Information:
Name(s) found: ATP7B_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6978561|ref|NP_036643.1| ATPase, Cu++ transporting, beta polypeptide [Rattus norvegicus] [NCBI NR]
  • gi|555676|gb|AAA62157.1| copper-transporting ATPase [NCBI NR]
  • gi|3121725|sp|Q64535.1|ATP7B_RAT RecName: Full=Copper-transporting ATPase 2; AltName: Full=Copper pump 2; AltName: Full=Wilson disease-associated protein homolog; AltName: Full=Pineal night-specific ATPase [NCBI NR]
  • pir||I58124 copper-transporting ATPase (EC 3.6.1.-) beta chain - rat [NCBI NR]
  • Copper-transporting ATPase 2 OS=Rattus norvegicus GN=Atp7b PE=1 SV=1 [Swiss-Prot]
  • (Q64535) Copper-transporting ATPase 2 (EC 3.6.3.4) (Copper pump 2) (Wilson disease-associated protein homolog) (Pinal night-specific ATPase) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):16-70448284 Splice isoform Long of Q64535 [hmr_yeast5_DM3-1_pombe.fasta]
  • ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease); ATPase Cu++ transporting beta polypeptide (same as Wilson disease) [HMR_022704-rand.fasta]
  • ATPase, Cu++ transporting, beta polypeptide [Rattus norvegicus]gi|2143667|pir||I58124 copper-transporting ATPase (EC 3.6.1.-) beta chain - ratgi|555676|gb|AAA62157.1| copper-transporting ATPasegi|3121725|sp|Q64535|AT7B_RAT Copper-transporting ATPase 2 [nrdb_11152004_Chlamydomonas]
  • (NM_012511) ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Copper-transporting ATPase 2 (Copper pump 2) (Wilson disease-associated protein homolog) (Pineal night-specific ATPase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • copper-transporting ATPase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ATPase, Cu++ transporting, beta polypeptide [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Atp7b Isoform Long of Copper-transporting ATPase 2 [rat-ipi-250309-contam.fasta]
  • Isoform Long of Copper-transporting ATPase 2 OS=Rattus norvegicus GN=Atp7b [011711_HMR.fasta]
  • Copper-transporting ATPase 2 OS=Rattus norvegicus GN=Atp7b PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 1451 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN]
    trans-Golgi network [UNKNOWN][IDA]
    tight junction [IDA]
    perinuclear region of cytoplasm [UNKNOWN]
    membrane [UNKNOWN][IEA]
    late endosome [UNKNOWN]
    integral to membrane [IEA]
    Golgi apparatus [IEA]
    cytoplasmic membrane-bounded vesicle [UNKNOWN]
    basolateral plasma membrane [UNKNOWN]
    plasma membrane [IDA]
    Biological Process: response to zinc ion [IEP]
    metabolic process [IEA]
    intracellular copper ion transport [UNKNOWN]
    cellular zinc ion homeostasis [UNKNOWN]
    response to copper ion [UNKNOWN][IEP]
    response to cAMP [IEP]
    lactation [UNKNOWN][IEP]
    ATP biosynthetic process [IEA]
    circadian rhythm [IEP]
    copper ion transport [UNKNOWN][IEA]
    ion transport [IEA]
    cellular copper ion homeostasis [UNKNOWN]
    sequestering of calcium ion [UNKNOWN]
    metal ion transport [IEA]
    copper ion import [UNKNOWN]
    Molecular Function: zinc ion binding [IDA]
    ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [IEA]
    metal ion transmembrane transporter activity [IEA]
    copper ion transmembrane transporter activity [IDA]
    nucleotide binding [IEA]
    ATP binding [UNKNOWN][IEA]
    copper-exporting ATPase activity [UNKNOWN][IEA][TAS]
    protein binding [UNKNOWN]
    copper ion binding [UNKNOWN][IDA][IEA]
    catalytic activity [IEA]
    metal ion binding [IEA]
    copper-transporting ATPase activity [UNKNOWN]
    hydrolase activity [IEA]
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEQERKVTA KEASRKILSK LALPTRPWGQ SMKQSFAFDN VGYEGGLDST CFILQLTTGV  60
   61 VSILGMTCHS CVKSIEDRIS SLKGIVSIKV SLEQGSATVK YVPSVLNLQQ ICLQIEDMGF 120
  121 EASAAEGKAA SWPSRSSPAQ EAVVKLRVEG MTCQSCVSSI EGKIRKLQGV VRVKVSLSNQ 180
  181 EAVITYQPYL IQPEDLRDHI CDMGFEAAIK NRTAPLRLGP IDINKLESTN LKRAAVPPIQ 240
  241 NSNHLETPGH QQNHLATLPL RIDGMHCKSC VLNIEGNIGQ LPGVQNIHVS LENKTAQVQY 300
  301 DSSCITPLFL QTAIEALPPG YFKVSLPDGL EKESGSSSVP SLGSSQRQQE PGPCRTAVLT 360
  361 ITGIPRDSSV QPMEDMLSQM KGVQQIDISL AEGTGAVLYD PSVVSSDELR TAVEDMGFEV 420
  421 SVNPENITTN RVSSGNSVPQ AVGDSPGSVQ NMASDTRGLL THQGPGYLSD SPPSPGGTAS 480
  481 QKCFVQIKGM TCASCVSNIE RSLQRHAGIL SVLVALMSGK AEVKYDPEVI QSPRIAQLIE 540
  541 DLGFEAAIME DNTVSEGDIE LIITGMTCAS CVHNIESKLT RTNGITYASV ALATSKAHVK 600
  601 FDPEIIGPRD IIKVIEEIGF HASLAHRNPN AHHLDHKTEI KQWKKSFLCS LVFGIPVMGL 660
  661 MIYMLIPSSK PHETMVLDHN IIPGLSVLNL IFFILCTFVQ FLGGWYFYVQ AYKSLRHKSA 720
  721 NMDVLIVLAT TIAYAYSLVI LVVAIAEKAE KSPVTFFDTP PMLFVFIALG RWLEHVAKSK 780
  781 TSEALAKLMS LQATEATVVT LGEDNLILRE EQVPMELVQR GDIIKVVPGG KFPVDGKVLE 840
  841 GNTMADESLI TGEAMPVTKK PGSIVIAGSI NAHGSVLIKA THVGNDTTLA QIVKLVEEAQ 900
  901 MSKAPIQQLA DRFSGYFVPF IIIISTLTLV VWIIIGFVDF GIVQKYFPSP SKHISQTEVI 960
  961 IRFAFQTSIT VLCIACPCSL GLATPTAVMV GTGVAAQNGV LIKGGKPLEM AHKIKTVMFD1020
 1021 KTGTITHGVP RVMRFLLLVD VATLSLRKVL AVVGTAEASS EHPLGVAVTK YCKEELGTET1080
 1081 LGYSTDFQAV PGCGISCKVS NVESILAHRG PTAHPIGVGN PPIGEGTGPQ TFSVLIGNRE1140
 1141 WMRRNGLTIS SDISDAMTDH EMKGQTAILV AIDGVLCGMI AIADAVKPEA ALASITLKSM1200
 1201 GVDVALITGD NRKTARAIAT QVGINKVFAE VLPSHKVAKV QELQNKGKKV AMVGDGVNDS1260
 1261 PALAQADVGI AIGTGTDVAI DAADVVLIRN DLLDVVASIH LSKRTVRRIR VNLVLALIYN1320
 1321 MVGIPIAAGV FMPIGIVLQP WMGSAAASSV SVVLSSLQLK CYRKPDLERY EAQAHGRMKP1380
 1381 LSASQVSVHV GMDDRRRDSP RATPWDQVSY VSQVSLSSLT SDRLSRHGGM AEDGGDKWSL1440
 1441 LLSDRDEEQC I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle